Sugi Variant

Sugi Variant/DAO

DAO — 93 ClinVar variants

All ClinVar germline DAO variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 49 flagged for review →

2 Conflicting · 19 Benign · 28 Likely benign · 44 Uncertain significance

Full DAO gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 49

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 18

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 31

The independent predictors disagree with each other — read with care.

All DAO variants

Conflicting classifications of pathogenicity 2

Benign 19

Likely benign 28

Uncertain significance 44