DAOA — 21 ClinVar variants
All ClinVar germline DAOA variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 12 flagged for review →
3 Benign · 6 Likely benign · 12 Uncertain significance
Full DAOA gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 12
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 12
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DAOA p.Ala108Pro Uncertain significance Single submitter
- DAOA p.Arg122His Uncertain significance Single submitter
- DAOA p.Arg128Gly Uncertain significance Single submitter
- DAOA p.Glu94Asp Uncertain significance Single submitter
- DAOA p.His76Arg Uncertain significance Single submitter
- DAOA p.Ile44Val Uncertain significance Single submitter
- DAOA p.Leu126Val Uncertain significance Single submitter
- DAOA p.Met72Ile Uncertain significance Single submitter
- DAOA p.Ser31Arg Uncertain significance Single submitter
- DAOA p.Ser31Gly Uncertain significance Single submitter
- DAOA p.Ser37Tyr Uncertain significance Single submitter
- DAOA p.Ser80Thr Uncertain significance Single submitter
All DAOA variants
Benign 3
- c.133+2T>A Single submitter
- c.281+8T>C Single submitter
- p.Gln136Glu Single submitter
Likely benign 6
- p.Arg75= Multiple submitters
- p.Arg122Cys Single submitter
- p.Gly68Ser Single submitter
- p.His65= Single submitter
- p.Ser31Asn Single submitter
- p.Ser80= Single submitter
Uncertain significance 12
- p.Ala108Pro Single submitter ⚠
- p.Arg122His Single submitter ⚠
- p.Arg128Gly Single submitter ⚠
- p.Glu94Asp Single submitter ⚠
- p.His76Arg Single submitter ⚠
- p.Ile44Val Single submitter ⚠
- p.Leu126Val Single submitter ⚠
- p.Met72Ile Single submitter ⚠
- p.Ser31Arg Single submitter ⚠
- p.Ser31Gly Single submitter ⚠
- p.Ser37Tyr Single submitter ⚠
- p.Ser80Thr Single submitter ⚠