DAP — 13 ClinVar variants
All ClinVar germline DAP variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 13 flagged for review →
13 Uncertain significance
Full DAP gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 13
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 5
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 8
The independent predictors disagree with each other — read with care.
- DAP p.Ala18Ser Uncertain significance Single submitter
- DAP p.Arg101His Uncertain significance Single submitter
- DAP p.Arg65Leu Uncertain significance Single submitter
- DAP p.Arg65Trp Uncertain significance Single submitter
- DAP p.Lys40Arg Uncertain significance Single submitter
- DAP p.Lys42Arg Uncertain significance Single submitter
- DAP p.Phe70Ile Uncertain significance Single submitter
- DAP p.Pro72Leu Uncertain significance Single submitter
All DAP variants
Uncertain significance 13
- p.Ala18Ser Single submitter ⚠
- p.Arg101His Single submitter ⚠
- p.Arg65Leu Single submitter ⚠
- p.Arg65Trp Single submitter ⚠
- p.Gln28Arg Single submitter ⚠
- p.Gln98His Single submitter ⚠
- p.Glu39Asp Single submitter ⚠
- p.His79Tyr Single submitter ⚠
- p.Lys40Arg Single submitter ⚠
- p.Lys42Arg Single submitter ⚠
- p.Phe70Ile Single submitter ⚠
- p.Pro4Thr Single submitter ⚠
- p.Pro72Leu Single submitter ⚠