DAPK1 — 222 ClinVar variants
All ClinVar germline DAPK1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 190 flagged for review →
16 Benign · 18 Likely benign · 188 Uncertain significance
Full DAPK1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 190
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 119
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DAPK1 p.Ala1165Thr Uncertain significance Single submitter
- DAPK1 p.Ala1165Val Uncertain significance Single submitter
- DAPK1 p.Ala227Thr Uncertain significance Single submitter
- DAPK1 p.Ala801Thr Uncertain significance Single submitter
- DAPK1 p.Ala97Val Uncertain significance Single submitter
- DAPK1 p.Arg1010Leu Uncertain significance Single submitter
- DAPK1 p.Arg1055Gln Uncertain significance Single submitter
- DAPK1 p.Arg1114Cys Uncertain significance Single submitter
- DAPK1 p.Arg1114His Uncertain significance Single submitter
- DAPK1 p.Arg1168Cys Uncertain significance Single submitter
- DAPK1 p.Arg1168His Uncertain significance Single submitter
- DAPK1 p.Arg1259Gln Uncertain significance Single submitter
- DAPK1 p.Arg1310Gln Uncertain significance Single submitter
- DAPK1 p.Arg1315Cys Uncertain significance Single submitter
- DAPK1 p.Arg156Gln Uncertain significance Single submitter
- DAPK1 p.Arg302Gly Uncertain significance Single submitter
- DAPK1 p.Arg302Trp Uncertain significance Single submitter
- DAPK1 p.Arg310Cys Uncertain significance Single submitter
- DAPK1 p.Arg47Lys Uncertain significance Single submitter
- DAPK1 p.Arg54Gln Uncertain significance Single submitter
- DAPK1 p.Arg575Lys Uncertain significance Single submitter
- DAPK1 p.Arg611Gln Uncertain significance Single submitter
- DAPK1 p.Arg627Gln Uncertain significance Single submitter
- DAPK1 p.Arg679Gln Uncertain significance Single submitter
- DAPK1 p.Arg759Lys Uncertain significance Single submitter
- DAPK1 p.Arg896Gln Uncertain significance Single submitter
- DAPK1 p.Asn1022Ser Uncertain significance Single submitter
- DAPK1 p.Asn1406Ser Uncertain significance Single submitter
- DAPK1 p.Asn1422His Uncertain significance Single submitter
- DAPK1 p.Asn233Ser Uncertain significance Single submitter
- DAPK1 p.Asn353Ser Uncertain significance Single submitter
- DAPK1 p.Asn472Ser Uncertain significance Single submitter
- DAPK1 p.Asn589Ser Uncertain significance Single submitter
- DAPK1 p.Asn602Asp Uncertain significance Single submitter
- DAPK1 p.Asn620Ser Uncertain significance Single submitter
- DAPK1 p.Asn926Ser Uncertain significance Single submitter
- DAPK1 p.Asn980Ser Uncertain significance Single submitter
- DAPK1 p.Asp10Asn Uncertain significance Single submitter
- DAPK1 p.Asp1321Asn Uncertain significance Single submitter
- DAPK1 p.Asp268Glu Uncertain significance Single submitter
- DAPK1 p.Asp371Asn Uncertain significance Single submitter
- DAPK1 p.Asp439Tyr Uncertain significance Single submitter
- DAPK1 p.Asp525Glu Uncertain significance Single submitter
- DAPK1 p.Asp543Asn Uncertain significance Single submitter
- DAPK1 p.Asp543Glu Uncertain significance Single submitter
- DAPK1 p.Asp571Asn Uncertain significance Single submitter
- DAPK1 p.Cys498Trp Uncertain significance Single submitter
- DAPK1 p.Cys540Tyr Uncertain significance Single submitter
- DAPK1 p.Cys959Ser Uncertain significance Single submitter
- DAPK1 p.Gln408Arg Uncertain significance Single submitter
- DAPK1 p.Gln996Arg Uncertain significance Single submitter
- DAPK1 p.Glu1020Lys Uncertain significance Single submitter
- DAPK1 p.Glu1122Lys Uncertain significance Single submitter
- DAPK1 p.Glu18Gly Uncertain significance Single submitter
- DAPK1 p.Glu340Lys Uncertain significance Single submitter
- DAPK1 p.Glu478Gly Uncertain significance Single submitter
- DAPK1 p.Glu558Asp Uncertain significance Single submitter
- DAPK1 p.Glu656Lys Uncertain significance Single submitter
- DAPK1 p.Gly1098Arg Uncertain significance Single submitter
- DAPK1 p.Gly126Asp Uncertain significance Single submitter
- DAPK1 p.Gly1273Glu Uncertain significance Single submitter
- DAPK1 p.Gly1348Glu Uncertain significance Single submitter
- DAPK1 p.Gly1418Ser Uncertain significance Single submitter
- DAPK1 p.Gly55Val Uncertain significance Single submitter
- DAPK1 p.Gly621Arg Uncertain significance Single submitter
- DAPK1 p.Gly621Val Uncertain significance Single submitter
- DAPK1 p.Gly873Ser Uncertain significance Single submitter
- DAPK1 p.His1058Asn Uncertain significance Single submitter
- DAPK1 p.His1359Gln Uncertain significance Single submitter
- DAPK1 p.His350Tyr Uncertain significance Single submitter
- DAPK1 p.Ile1219Thr Uncertain significance Single submitter
- DAPK1 p.Ile1251Thr Uncertain significance Single submitter
- DAPK1 p.Ile1300Met Uncertain significance Single submitter
- DAPK1 p.Ile546Thr Uncertain significance Single submitter
- DAPK1 p.Ile870Val Uncertain significance Single submitter
- DAPK1 p.Ile924Val Uncertain significance Single submitter
- DAPK1 p.Leu1033Val Uncertain significance Single submitter
- DAPK1 p.Leu1323Arg Uncertain significance Single submitter
- DAPK1 p.Leu1354Pro Uncertain significance Single submitter
- DAPK1 p.Leu383Phe Uncertain significance Single submitter
- DAPK1 p.Leu678Val Uncertain significance Single submitter
- DAPK1 p.Leu736Pro Uncertain significance Single submitter
- DAPK1 p.Lys1276Arg Uncertain significance Single submitter
- DAPK1 p.Lys1312Arg Uncertain significance Single submitter
- DAPK1 p.Lys1351Arg Uncertain significance Single submitter
- DAPK1 p.Lys1351Asn Uncertain significance Single submitter
- DAPK1 p.Lys1400Arg Uncertain significance Single submitter
- DAPK1 p.Lys262Arg Uncertain significance Single submitter
- DAPK1 p.Lys278Asn Uncertain significance Single submitter
- DAPK1 p.Met1283Ile Uncertain significance Single submitter
- DAPK1 p.Met1298Val Uncertain significance Single submitter
- DAPK1 p.Met1377Ile Uncertain significance Single submitter
- DAPK1 p.Pro155Leu Uncertain significance Single submitter
- DAPK1 p.Pro591His Uncertain significance Single submitter
- DAPK1 p.Pro591Leu Uncertain significance Single submitter
- DAPK1 p.Ser1076Gly Uncertain significance Single submitter
- DAPK1 p.Ser1214Leu Uncertain significance Single submitter
- DAPK1 p.Ser652Leu Uncertain significance Single submitter
- DAPK1 p.Ser729Asn Uncertain significance Single submitter
- DAPK1 p.Ser787Leu Uncertain significance Single submitter
- DAPK1 p.Ser841Asn Uncertain significance Single submitter
- DAPK1 p.Ser957Ala Uncertain significance Single submitter
- DAPK1 p.Thr1042Arg Uncertain significance Single submitter
- DAPK1 p.Thr1138Ser Uncertain significance Single submitter
- DAPK1 p.Thr1225Ser Uncertain significance Single submitter
- DAPK1 p.Thr726Ala Uncertain significance Single submitter
- DAPK1 p.Thr726Ile Uncertain significance Single submitter
- DAPK1 p.Thr972Met Uncertain significance Single submitter
- DAPK1 p.Trp418Arg Uncertain significance Single submitter
- DAPK1 p.Tyr455Cys Uncertain significance Single submitter
- DAPK1 p.Tyr491Cys Uncertain significance Single submitter
- DAPK1 p.Tyr491His Uncertain significance Single submitter
- DAPK1 p.Val1249Ile Uncertain significance Single submitter
- DAPK1 p.Val1290Ile Uncertain significance Single submitter
- DAPK1 p.Val1340Leu Uncertain significance Single submitter
- DAPK1 p.Val527Met Uncertain significance Single submitter
- DAPK1 p.Val943Ile Uncertain significance Single submitter
- DAPK1 p.Val96Phe Uncertain significance Single submitter
-
DAPK1 p.Asp139His
Uncertain significance
No assertion criteria
myoepithelial tumor
Predictors split 71
The independent predictors disagree with each other — read with care.
- DAPK1 p.Ala1092Thr Uncertain significance Single submitter
- DAPK1 p.Ala599Val Uncertain significance Single submitter
- DAPK1 p.Arg1055Trp Uncertain significance Single submitter
- DAPK1 p.Arg1061Trp Uncertain significance Single submitter
- DAPK1 p.Arg1071Cys Uncertain significance Single submitter
- DAPK1 p.Arg1071His Uncertain significance Single submitter
- DAPK1 p.Arg1154Gln Uncertain significance Single submitter
- DAPK1 p.Arg1199Cys Uncertain significance Single submitter
- DAPK1 p.Arg1310Gly Uncertain significance Single submitter
- DAPK1 p.Arg31Cys Uncertain significance Single submitter
- DAPK1 p.Arg320Gly Uncertain significance Single submitter
- DAPK1 p.Arg671Gln Uncertain significance Single submitter
- DAPK1 p.Arg720Trp Uncertain significance Single submitter
- DAPK1 p.Asn508Ser Uncertain significance Single submitter
- DAPK1 p.Asn578Ser Uncertain significance Single submitter
- DAPK1 p.Asp1289Asn Uncertain significance Single submitter
- DAPK1 p.Asp426Asn Uncertain significance Single submitter
- DAPK1 p.Asp459Asn Uncertain significance Single submitter
- DAPK1 p.Asp536Asn Uncertain significance Single submitter
- DAPK1 p.Cys1091Ser Uncertain significance Single submitter
- DAPK1 p.Cys1153Trp Uncertain significance Single submitter
- DAPK1 p.Cys1216Tyr Uncertain significance Single submitter
- DAPK1 p.Cys601Gly Uncertain significance Single submitter
- DAPK1 p.Cys966Phe Uncertain significance Single submitter
- DAPK1 p.Gln1261His Uncertain significance Single submitter
- DAPK1 p.Gln316Arg Uncertain significance Single submitter
- DAPK1 p.Gln852His Uncertain significance Single submitter
- DAPK1 p.Gln989His Uncertain significance Single submitter
- DAPK1 p.Glu1182Lys Uncertain significance Single submitter
- DAPK1 p.Glu237Gly Uncertain significance Single submitter
- DAPK1 p.Glu59Gln Uncertain significance Single submitter
- DAPK1 p.Gly1273Arg Uncertain significance Single submitter
- DAPK1 p.Gly1418Val Uncertain significance Single submitter
- DAPK1 p.Gly501Ser Uncertain significance Single submitter
- DAPK1 p.Gly981Glu Uncertain significance Single submitter
- DAPK1 p.His533Tyr Uncertain significance Single submitter
- DAPK1 p.His655Gln Uncertain significance Single submitter
- DAPK1 p.Ile177Met Uncertain significance Single submitter
- DAPK1 p.Ile796Met Uncertain significance Single submitter
- DAPK1 p.Leu537Val Uncertain significance Single submitter
- DAPK1 p.Leu707Phe Uncertain significance Single submitter
- DAPK1 p.Leu857Phe Uncertain significance Single submitter
- DAPK1 p.Lys28Gln Uncertain significance Single submitter
- DAPK1 p.Lys298Asn Uncertain significance Single submitter
- DAPK1 p.Lys303Thr Uncertain significance Single submitter
- DAPK1 p.Met1100Ile Uncertain significance Single submitter
- DAPK1 p.Met1272Ile Likely benign Single submitter
- DAPK1 p.Met763Thr Uncertain significance Single submitter
- DAPK1 p.Phe693Leu Uncertain significance Single submitter
- DAPK1 p.Pro960Ala Uncertain significance Single submitter
- DAPK1 p.Ser1413Trp Uncertain significance Single submitter
- DAPK1 p.Ser1429Phe Uncertain significance Single submitter
- DAPK1 p.Ser321Ala Uncertain significance Single submitter
- DAPK1 p.Ser469Pro Uncertain significance Single submitter
- DAPK1 p.Ser565Ile Uncertain significance Single submitter
- DAPK1 p.Ser858Arg Uncertain significance Single submitter
- DAPK1 p.Thr1309Ile Uncertain significance Single submitter
- DAPK1 p.Thr1366Asn Uncertain significance Single submitter
- DAPK1 p.Thr480Ser Uncertain significance Single submitter
- DAPK1 p.Thr640Ile Uncertain significance Single submitter
- DAPK1 p.Tyr750His Uncertain significance Single submitter
- DAPK1 p.Val1044Ile Uncertain significance Single submitter
- DAPK1 p.Val1129Met Uncertain significance Single submitter
- DAPK1 p.Val257Ile Uncertain significance Single submitter
- DAPK1 p.Val372Ile Uncertain significance Single submitter
- DAPK1 p.Val460Met Uncertain significance Single submitter
- DAPK1 p.Val504Met Uncertain significance Single submitter
- DAPK1 p.Val636Ile Uncertain significance Single submitter
- DAPK1 p.Val658Leu Likely benign Single submitter
- DAPK1 p.Val811Met Uncertain significance Single submitter
- DAPK1 p.Val819Met Uncertain significance Single submitter
All DAPK1 variants
Benign 16
- c.1131+9C>T Multiple submitters
- c.1231-6C>G Multiple submitters
- c.285-6T>C Multiple submitters
- c.919-10T>A Multiple submitters
- p.Asn1347= Multiple submitters
- p.Gln122= Multiple submitters
- p.Gly1405Val Multiple submitters
- p.His657= Multiple submitters
- p.Leu431= Multiple submitters
- p.Ser1292= Multiple submitters
- p.Ser403= Multiple submitters
- p.Val992= Multiple submitters
- c.1132-7A>G Single submitter
- c.3061-4G>A Single submitter
- c.783-9C>G Single submitter
- c.919-10_919-9insTA Single submitter
Likely benign 18
- c.919-9A>T Multiple submitters
- p.Gly1348Val Multiple submitters
- p.His1288= Multiple submitters
- p.Ala1388= Single submitter
- p.Arg1010His Single submitter
- p.Arg1363Gln Single submitter
- p.Arg575= Single submitter
- p.Asn800= Single submitter
- p.Asp11= Single submitter
- p.Asp14= Single submitter
- p.Gly213= Single submitter
- p.His533= Single submitter
- p.Met1272Ile Single submitter ⚠
- p.Met447Thr Single submitter
- p.Pro1133= Single submitter
- p.Val1066Met Single submitter
- p.Val1103Ile Single submitter
- p.Val658Leu Single submitter ⚠
Uncertain significance 188
- p.Ala1092Thr Single submitter ⚠
- p.Ala1165Thr Single submitter ⚠
- p.Ala1165Val Single submitter ⚠
- p.Ala227Thr Single submitter ⚠
- p.Ala599Val Single submitter ⚠
- p.Ala801Thr Single submitter ⚠
- p.Ala97Val Single submitter ⚠
- p.Arg1010Leu Single submitter ⚠
- p.Arg1055Gln Single submitter ⚠
- p.Arg1055Trp Single submitter ⚠
- p.Arg1061Trp Single submitter ⚠
- p.Arg1071Cys Single submitter ⚠
- p.Arg1071His Single submitter ⚠
- p.Arg1114Cys Single submitter ⚠
- p.Arg1114His Single submitter ⚠
- p.Arg1154Gln Single submitter ⚠
- p.Arg1168Cys Single submitter ⚠
- p.Arg1168His Single submitter ⚠
- p.Arg1199Cys Single submitter ⚠
- p.Arg1259Gln Single submitter ⚠
- p.Arg1310Gln Single submitter ⚠
- p.Arg1310Gly Single submitter ⚠
- p.Arg1315Cys Single submitter ⚠
- p.Arg156Gln Single submitter ⚠
- p.Arg302Gly Single submitter ⚠
- p.Arg302Trp Single submitter ⚠
- p.Arg310Cys Single submitter ⚠
- p.Arg31Cys Single submitter ⚠
- p.Arg320Gly Single submitter ⚠
- p.Arg47Lys Single submitter ⚠
- p.Arg54Gln Single submitter ⚠
- p.Arg575Lys Single submitter ⚠
- p.Arg611Gln Single submitter ⚠
- p.Arg627Gln Single submitter ⚠
- p.Arg671Gln Single submitter ⚠
- p.Arg679Gln Single submitter ⚠
- p.Arg720Trp Single submitter ⚠
- p.Arg759Lys Single submitter ⚠
- p.Arg896Gln Single submitter ⚠
- p.Asn1022Ser Single submitter ⚠
- p.Asn1406Ser Single submitter ⚠
- p.Asn1422His Single submitter ⚠
- p.Asn233Ser Single submitter ⚠
- p.Asn353Ser Single submitter ⚠
- p.Asn472Ser Single submitter ⚠
- p.Asn508Ser Single submitter ⚠
- p.Asn578Ser Single submitter ⚠
- p.Asn589Ser Single submitter ⚠
- p.Asn602Asp Single submitter ⚠
- p.Asn620Ser Single submitter ⚠
- p.Asn926Ser Single submitter ⚠
- p.Asn980Ser Single submitter ⚠
- p.Asp10Asn Single submitter ⚠
- p.Asp1289Asn Single submitter ⚠
- p.Asp1321Asn Single submitter ⚠
- p.Asp268Glu Single submitter ⚠
- p.Asp371Asn Single submitter ⚠
- p.Asp426Asn Single submitter ⚠
- p.Asp439Tyr Single submitter ⚠
- p.Asp459Asn Single submitter ⚠
- p.Asp525Glu Single submitter ⚠
- p.Asp536Asn Single submitter ⚠
- p.Asp543Asn Single submitter ⚠
- p.Asp543Glu Single submitter ⚠
- p.Asp571Asn Single submitter ⚠
- p.Cys1091Ser Single submitter ⚠
- p.Cys1153Trp Single submitter ⚠
- p.Cys1216Tyr Single submitter ⚠
- p.Cys498Trp Single submitter ⚠
- p.Cys540Tyr Single submitter ⚠
- p.Cys601Gly Single submitter ⚠
- p.Cys959Ser Single submitter ⚠
- p.Cys966Phe Single submitter ⚠
- p.Gln1261His Single submitter ⚠
- p.Gln316Arg Single submitter ⚠
- p.Gln408Arg Single submitter ⚠
- p.Gln852His Single submitter ⚠
- p.Gln989His Single submitter ⚠
- p.Gln996Arg Single submitter ⚠
- p.Glu1020Lys Single submitter ⚠
- p.Glu1122Lys Single submitter ⚠
- p.Glu1182Lys Single submitter ⚠
- p.Glu18Gly Single submitter ⚠
- p.Glu237Gly Single submitter ⚠
- p.Glu340Lys Single submitter ⚠
- p.Glu478Gly Single submitter ⚠
- p.Glu558Asp Single submitter ⚠
- p.Glu59Gln Single submitter ⚠
- p.Glu656Lys Single submitter ⚠
- p.Gly1098Arg Single submitter ⚠
- p.Gly126Asp Single submitter ⚠
- p.Gly1273Arg Single submitter ⚠
- p.Gly1273Glu Single submitter ⚠
- p.Gly1348Glu Single submitter ⚠
- p.Gly1418Ser Single submitter ⚠
- p.Gly1418Val Single submitter ⚠
- p.Gly501Ser Single submitter ⚠
- p.Gly55Val Single submitter ⚠
- p.Gly621Arg Single submitter ⚠
- p.Gly621Val Single submitter ⚠
- p.Gly873Ser Single submitter ⚠
- p.Gly981Glu Single submitter ⚠
- p.His1058Asn Single submitter ⚠
- p.His1359Gln Single submitter ⚠
- p.His350Tyr Single submitter ⚠
- p.His533Tyr Single submitter ⚠
- p.His655Gln Single submitter ⚠
- p.Ile1219Thr Single submitter ⚠
- p.Ile1251Thr Single submitter ⚠
- p.Ile1300Met Single submitter ⚠
- p.Ile177Met Single submitter ⚠
- p.Ile546Thr Single submitter ⚠
- p.Ile796Met Single submitter ⚠
- p.Ile870Val Single submitter ⚠
- p.Ile924Val Single submitter ⚠
- p.Leu1033Val Single submitter ⚠
- p.Leu1323Arg Single submitter ⚠
- p.Leu1354Pro Single submitter ⚠
- p.Leu383Phe Single submitter ⚠
- p.Leu537Val Single submitter ⚠
- p.Leu678Val Single submitter ⚠
- p.Leu707Phe Single submitter ⚠
- p.Leu736Pro Single submitter ⚠
- p.Leu857Phe Single submitter ⚠
- p.Lys1276Arg Single submitter ⚠
- p.Lys1312Arg Single submitter ⚠
- p.Lys1351Arg Single submitter ⚠
- p.Lys1351Asn Single submitter ⚠
- p.Lys1400Arg Single submitter ⚠
- p.Lys262Arg Single submitter ⚠
- p.Lys278Asn Single submitter ⚠
- p.Lys28Gln Single submitter ⚠
- p.Lys298Asn Single submitter ⚠
- p.Lys303Thr Single submitter ⚠
- p.Met1100Ile Single submitter ⚠
- p.Met1283Ile Single submitter ⚠
- p.Met1298Val Single submitter ⚠
- p.Met1377Ile Single submitter ⚠
- p.Met763Thr Single submitter ⚠
- p.Phe693Leu Single submitter ⚠
- p.Pro155Leu Single submitter ⚠
- p.Pro591His Single submitter ⚠
- p.Pro591Leu Single submitter ⚠
- p.Pro960Ala Single submitter ⚠
- p.Ser1076Gly Single submitter ⚠
- p.Ser1214Leu Single submitter ⚠
- p.Ser1413Trp Single submitter ⚠
- p.Ser1429Phe Single submitter ⚠
- p.Ser321Ala Single submitter ⚠
- p.Ser469Pro Single submitter ⚠
- p.Ser565Ile Single submitter ⚠
- p.Ser652Leu Single submitter ⚠
- p.Ser729Asn Single submitter ⚠
- p.Ser787Leu Single submitter ⚠
- p.Ser841Asn Single submitter ⚠
- p.Ser858Arg Single submitter ⚠
- p.Ser957Ala Single submitter ⚠
- p.Thr1042Arg Single submitter ⚠
- p.Thr1138Ser Single submitter ⚠
- p.Thr1225Ser Single submitter ⚠
- p.Thr1309Ile Single submitter ⚠
- p.Thr1366Asn Single submitter ⚠
- p.Thr480Ser Single submitter ⚠
- p.Thr640Ile Single submitter ⚠
- p.Thr726Ala Single submitter ⚠
- p.Thr726Ile Single submitter ⚠
- p.Thr972Met Single submitter ⚠
- p.Trp418Arg Single submitter ⚠
- p.Tyr455Cys Single submitter ⚠
- p.Tyr491Cys Single submitter ⚠
- p.Tyr491His Single submitter ⚠
- p.Tyr750His Single submitter ⚠
- p.Val1044Ile Single submitter ⚠
- p.Val1129Met Single submitter ⚠
- p.Val1249Ile Single submitter ⚠
- p.Val1290Ile Single submitter ⚠
- p.Val1340Leu Single submitter ⚠
- p.Val257Ile Single submitter ⚠
- p.Val372Ile Single submitter ⚠
- p.Val460Met Single submitter ⚠
- p.Val504Met Single submitter ⚠
- p.Val527Met Single submitter ⚠
- p.Val636Ile Single submitter ⚠
- p.Val811Met Single submitter ⚠
- p.Val819Met Single submitter ⚠
- p.Val943Ile Single submitter ⚠
- p.Val96Phe Single submitter ⚠
- p.Asp139His No assertion criteria myoepithelial tumor ⚠