DAPK2 — 68 ClinVar variants
All ClinVar germline DAPK2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 63 flagged for review →
3 Benign · 2 Benign/Likely benign · 2 Likely benign · 61 Uncertain significance
Full DAPK2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 63
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 33
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DAPK2 p.Ala175Pro Uncertain significance Single submitter
- DAPK2 p.Ala175Val Uncertain significance Single submitter
- DAPK2 p.Arg273Gln Uncertain significance Single submitter
- DAPK2 p.Arg273Trp Uncertain significance Single submitter
- DAPK2 p.Arg312Cys Uncertain significance Single submitter
- DAPK2 p.Arg314Trp Uncertain significance Single submitter
- DAPK2 p.Arg57Trp Uncertain significance Single submitter
- DAPK2 p.Asp113Asn Uncertain significance Single submitter
- DAPK2 p.Asp135Glu Uncertain significance Single submitter
- DAPK2 p.Glu202Lys Uncertain significance Single submitter
- DAPK2 p.Glu256Asp Uncertain significance Single submitter
- DAPK2 p.Glu298Lys Uncertain significance Single submitter
- DAPK2 p.Glu74Asp Uncertain significance Single submitter
- DAPK2 p.Gly223Arg Uncertain significance Single submitter
- DAPK2 p.Gly65Ser Uncertain significance Single submitter
- DAPK2 p.His337Gln Uncertain significance Single submitter
- DAPK2 p.Leu228Pro Uncertain significance Single submitter
- DAPK2 p.Lys151Gln Uncertain significance Single submitter
- DAPK2 p.Lys55Thr Uncertain significance Single submitter
- DAPK2 p.Met6Val Uncertain significance Single submitter
- DAPK2 p.Phe188Ser Uncertain significance Single submitter
- DAPK2 p.Phe34Ser Uncertain significance Single submitter
- DAPK2 p.Phe53Ser Uncertain significance Single submitter
- DAPK2 p.Pro152Leu Uncertain significance Single submitter
- DAPK2 p.Pro165Ser Uncertain significance Single submitter
- DAPK2 p.Ser243Asn Uncertain significance Single submitter
- DAPK2 p.Ser323Tyr Uncertain significance Single submitter
- DAPK2 p.Ser331Leu Uncertain significance Single submitter
- DAPK2 p.Tyr49Phe Uncertain significance Single submitter
- DAPK2 p.Val137Met Uncertain significance Single submitter
- DAPK2 p.Val311Ile Uncertain significance Single submitter
- DAPK2 p.Val336Met Uncertain significance Single submitter
- DAPK2 p.Val37Met Uncertain significance Single submitter
Predictors split 30
The independent predictors disagree with each other — read with care.
- DAPK2 p.Arg60Gln Likely benign Multiple submitters
- DAPK2 p.Arg68Gln Benign/Likely benign Multiple submitters
- DAPK2 p.Ala126Val Uncertain significance Single submitter
- DAPK2 p.Arg263Trp Uncertain significance Single submitter
- DAPK2 p.Arg271Trp Uncertain significance Single submitter
- DAPK2 p.Arg296Cys Uncertain significance Single submitter
- DAPK2 p.Arg312His Uncertain significance Single submitter
- DAPK2 p.Arg41Gln Uncertain significance Single submitter
- DAPK2 p.Arg41Trp Uncertain significance Single submitter
- DAPK2 p.Arg63Gln Uncertain significance Single submitter
- DAPK2 p.Arg96His Uncertain significance Single submitter
- DAPK2 p.Asn85Ser Uncertain significance Single submitter
- DAPK2 p.Asn95Asp Uncertain significance Single submitter
- DAPK2 p.Asp245Asn Uncertain significance Single submitter
- DAPK2 p.Asp260Val Uncertain significance Single submitter
- DAPK2 p.Cys325Arg Uncertain significance Single submitter
- DAPK2 p.Glu207Gly Uncertain significance Single submitter
- DAPK2 p.Glu256Lys Uncertain significance Single submitter
- DAPK2 p.Glu348Lys Uncertain significance Single submitter
- DAPK2 p.Glu352Val Uncertain significance Single submitter
- DAPK2 p.Glu72Lys Uncertain significance Single submitter
- DAPK2 p.His176Gln Uncertain significance Single submitter
- DAPK2 p.Met210Val Uncertain significance Single submitter
- DAPK2 p.Phe129Leu Uncertain significance Single submitter
- DAPK2 p.Pro283Ser Uncertain significance Single submitter
- DAPK2 p.Ser331Trp Uncertain significance Single submitter
- DAPK2 p.Thr142Pro Uncertain significance Single submitter
- DAPK2 p.Thr369Asn Uncertain significance Single submitter
- DAPK2 p.Thr45Met Uncertain significance Single submitter
- DAPK2 p.Val137Leu Uncertain significance Single submitter
All DAPK2 variants
Benign/Likely benign 2
- c.632+8G>T Multiple submitters
- p.Arg68Gln Multiple submitters ⚠
Likely benign 2
- p.Arg60= Multiple submitters
- p.Arg60Gln Multiple submitters ⚠
Uncertain significance 61
- p.Ala126Val Single submitter ⚠
- p.Ala175Pro Single submitter ⚠
- p.Ala175Val Single submitter ⚠
- p.Arg263Trp Single submitter ⚠
- p.Arg271Trp Single submitter ⚠
- p.Arg273Gln Single submitter ⚠
- p.Arg273Trp Single submitter ⚠
- p.Arg296Cys Single submitter ⚠
- p.Arg312Cys Single submitter ⚠
- p.Arg312His Single submitter ⚠
- p.Arg314Trp Single submitter ⚠
- p.Arg41Gln Single submitter ⚠
- p.Arg41Trp Single submitter ⚠
- p.Arg57Trp Single submitter ⚠
- p.Arg63Gln Single submitter ⚠
- p.Arg96His Single submitter ⚠
- p.Asn85Ser Single submitter ⚠
- p.Asn95Asp Single submitter ⚠
- p.Asp113Asn Single submitter ⚠
- p.Asp135Glu Single submitter ⚠
- p.Asp245Asn Single submitter ⚠
- p.Asp260Val Single submitter ⚠
- p.Cys325Arg Single submitter ⚠
- p.Glu202Lys Single submitter ⚠
- p.Glu207Gly Single submitter ⚠
- p.Glu256Asp Single submitter ⚠
- p.Glu256Lys Single submitter ⚠
- p.Glu298Lys Single submitter ⚠
- p.Glu348Lys Single submitter ⚠
- p.Glu352Val Single submitter ⚠
- p.Glu72Lys Single submitter ⚠
- p.Glu74Asp Single submitter ⚠
- p.Gly223Arg Single submitter ⚠
- p.Gly65Ser Single submitter ⚠
- p.His176Gln Single submitter ⚠
- p.His337Gln Single submitter ⚠
- p.Leu228Pro Single submitter ⚠
- p.Lys151Gln Single submitter ⚠
- p.Lys55Thr Single submitter ⚠
- p.Met210Val Single submitter ⚠
- p.Met6Val Single submitter ⚠
- p.Phe129Leu Single submitter ⚠
- p.Phe188Ser Single submitter ⚠
- p.Phe34Ser Single submitter ⚠
- p.Phe53Ser Single submitter ⚠
- p.Pro152Leu Single submitter ⚠
- p.Pro165Ser Single submitter ⚠
- p.Pro283Ser Single submitter ⚠
- p.Ser243Asn Single submitter ⚠
- p.Ser323Tyr Single submitter ⚠
- p.Ser331Leu Single submitter ⚠
- p.Ser331Trp Single submitter ⚠
- p.Thr142Pro Single submitter ⚠
- p.Thr369Asn Single submitter ⚠
- p.Thr45Met Single submitter ⚠
- p.Tyr49Phe Single submitter ⚠
- p.Val137Leu Single submitter ⚠
- p.Val137Met Single submitter ⚠
- p.Val311Ile Single submitter ⚠
- p.Val336Met Single submitter ⚠
- p.Val37Met Single submitter ⚠