DAPK3 — 71 ClinVar variants
All ClinVar germline DAPK3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 69 flagged for review →
1 Benign · 1 Likely benign · 69 Uncertain significance
Full DAPK3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 69
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 35
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DAPK3 p.Ala170Val Uncertain significance Single submitter
- DAPK3 p.Ala267Val Uncertain significance Single submitter
- DAPK3 p.Ala355Ser Uncertain significance Single submitter
- DAPK3 p.Ala428Val Uncertain significance Single submitter
- DAPK3 p.Arg134His Uncertain significance Single submitter
- DAPK3 p.Arg281Gln Uncertain significance Single submitter
- DAPK3 p.Arg284Leu Uncertain significance Single submitter
- DAPK3 p.Arg382Pro Uncertain significance Single submitter
- DAPK3 p.Arg412Ser Uncertain significance Single submitter
- DAPK3 p.Asn75Lys Uncertain significance Single submitter
- DAPK3 p.Asp125Asn Uncertain significance Single submitter
- DAPK3 p.Asp352Val Uncertain significance Single submitter
- DAPK3 p.Gln443Arg Uncertain significance Single submitter
- DAPK3 p.Glu115Lys Uncertain significance Single submitter
- DAPK3 p.Glu293Gln Uncertain significance Single submitter
- DAPK3 p.Glu336Lys Uncertain significance Single submitter
- DAPK3 p.Glu362Ala Uncertain significance Single submitter
- DAPK3 p.Glu370Lys Uncertain significance Single submitter
- DAPK3 p.Gly204Ser Uncertain significance Single submitter
- DAPK3 p.Gly289Asp Uncertain significance Single submitter
- DAPK3 p.Gly408Cys Uncertain significance Single submitter
- DAPK3 p.His73Tyr Uncertain significance Single submitter
- DAPK3 p.Ile203Val Uncertain significance Single submitter
- DAPK3 p.Lys291Gln Uncertain significance Single submitter
- DAPK3 p.Lys327Glu Uncertain significance Single submitter
- DAPK3 p.Pro193Ser Uncertain significance Single submitter
- DAPK3 p.Ser288Arg Uncertain significance Single submitter
- DAPK3 p.Ser309Leu Uncertain significance Single submitter
- DAPK3 p.Ser326Phe Uncertain significance Single submitter
- DAPK3 p.Ser52Ile Uncertain significance Single submitter
- DAPK3 p.Val152Leu Uncertain significance Single submitter
- DAPK3 p.Val27Leu Uncertain significance Single submitter
- DAPK3 p.Val328Met Uncertain significance Single submitter
- DAPK3 p.Val353Met Uncertain significance Single submitter
- DAPK3 p.Val438Met Uncertain significance Single submitter
Predictors split 34
The independent predictors disagree with each other — read with care.
- DAPK3 p.Ala332Glu Uncertain significance Single submitter
- DAPK3 p.Ala390Val Uncertain significance Single submitter
- DAPK3 p.Ala395Pro Uncertain significance Single submitter
- DAPK3 p.Arg134Cys Uncertain significance Single submitter
- DAPK3 p.Arg156Gln Uncertain significance Single submitter
- DAPK3 p.Arg253Leu Uncertain significance Single submitter
- DAPK3 p.Arg262Gly Uncertain significance Single submitter
- DAPK3 p.Arg28Gln Uncertain significance Single submitter
- DAPK3 p.Arg28Trp Uncertain significance Single submitter
- DAPK3 p.Arg295Trp Uncertain significance Single submitter
- DAPK3 p.Arg301His Uncertain significance Single submitter
- DAPK3 p.Arg344Gly Uncertain significance Single submitter
- DAPK3 p.Arg379Pro Uncertain significance Single submitter
- DAPK3 p.Arg379Trp Uncertain significance Single submitter
- DAPK3 p.Arg411His Uncertain significance Single submitter
- DAPK3 p.Arg412Leu Uncertain significance Single submitter
- DAPK3 p.Arg419Cys Uncertain significance Single submitter
- DAPK3 p.Arg419His Uncertain significance Single submitter
- DAPK3 p.Arg63Gln Uncertain significance Single submitter
- DAPK3 p.Arg72Trp Uncertain significance Single submitter
- DAPK3 p.Glu351Lys Uncertain significance Single submitter
- DAPK3 p.Glu398Ala Uncertain significance Single submitter
- DAPK3 p.Glu62Gln Uncertain significance Single submitter
- DAPK3 p.Glu62Lys Uncertain significance Single submitter
- DAPK3 p.Leu130Met Uncertain significance Single submitter
- DAPK3 p.Leu374Val Uncertain significance Single submitter
- DAPK3 p.Leu404Met Uncertain significance Single submitter
- DAPK3 p.Lys86Glu Uncertain significance Single submitter
- DAPK3 p.Ser373Asn Uncertain significance Single submitter
- DAPK3 p.Ser429Phe Uncertain significance Single submitter
- DAPK3 p.Ser97Cys Uncertain significance Single submitter
- DAPK3 p.Thr299Ile Uncertain significance Single submitter
- DAPK3 p.Val127Ile Uncertain significance Single submitter
- DAPK3 p.Val257Ile Uncertain significance Single submitter
All DAPK3 variants
Benign 1
- p.Ala198= Multiple submitters
Likely benign 1
- p.Tyr234= Single submitter
Uncertain significance 69
- p.Ala170Val Single submitter ⚠
- p.Ala267Val Single submitter ⚠
- p.Ala332Glu Single submitter ⚠
- p.Ala355Ser Single submitter ⚠
- p.Ala390Val Single submitter ⚠
- p.Ala395Pro Single submitter ⚠
- p.Ala428Val Single submitter ⚠
- p.Arg134Cys Single submitter ⚠
- p.Arg134His Single submitter ⚠
- p.Arg156Gln Single submitter ⚠
- p.Arg253Leu Single submitter ⚠
- p.Arg262Gly Single submitter ⚠
- p.Arg281Gln Single submitter ⚠
- p.Arg284Leu Single submitter ⚠
- p.Arg28Gln Single submitter ⚠
- p.Arg28Trp Single submitter ⚠
- p.Arg295Trp Single submitter ⚠
- p.Arg301His Single submitter ⚠
- p.Arg344Gly Single submitter ⚠
- p.Arg379Pro Single submitter ⚠
- p.Arg379Trp Single submitter ⚠
- p.Arg382Pro Single submitter ⚠
- p.Arg411His Single submitter ⚠
- p.Arg412Leu Single submitter ⚠
- p.Arg412Ser Single submitter ⚠
- p.Arg419Cys Single submitter ⚠
- p.Arg419His Single submitter ⚠
- p.Arg63Gln Single submitter ⚠
- p.Arg72Trp Single submitter ⚠
- p.Asn75Lys Single submitter ⚠
- p.Asp125Asn Single submitter ⚠
- p.Asp352Val Single submitter ⚠
- p.Gln443Arg Single submitter ⚠
- p.Glu115Lys Single submitter ⚠
- p.Glu293Gln Single submitter ⚠
- p.Glu336Lys Single submitter ⚠
- p.Glu351Lys Single submitter ⚠
- p.Glu362Ala Single submitter ⚠
- p.Glu370Lys Single submitter ⚠
- p.Glu398Ala Single submitter ⚠
- p.Glu62Gln Single submitter ⚠
- p.Glu62Lys Single submitter ⚠
- p.Gly204Ser Single submitter ⚠
- p.Gly289Asp Single submitter ⚠
- p.Gly408Cys Single submitter ⚠
- p.His73Tyr Single submitter ⚠
- p.Ile203Val Single submitter ⚠
- p.Leu130Met Single submitter ⚠
- p.Leu374Val Single submitter ⚠
- p.Leu404Met Single submitter ⚠
- p.Lys291Gln Single submitter ⚠
- p.Lys327Glu Single submitter ⚠
- p.Lys86Glu Single submitter ⚠
- p.Pro193Ser Single submitter ⚠
- p.Ser288Arg Single submitter ⚠
- p.Ser309Leu Single submitter ⚠
- p.Ser326Phe Single submitter ⚠
- p.Ser373Asn Single submitter ⚠
- p.Ser429Phe Single submitter ⚠
- p.Ser52Ile Single submitter ⚠
- p.Ser97Cys Single submitter ⚠
- p.Thr299Ile Single submitter ⚠
- p.Val127Ile Single submitter ⚠
- p.Val152Leu Single submitter ⚠
- p.Val257Ile Single submitter ⚠
- p.Val27Leu Single submitter ⚠
- p.Val328Met Single submitter ⚠
- p.Val353Met Single submitter ⚠
- p.Val438Met Single submitter ⚠