DAPL1 — 24 ClinVar variants
All ClinVar germline DAPL1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 22 flagged for review →
2 Likely benign · 22 Uncertain significance
Full DAPL1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 22
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 19
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DAPL1 p.Ala22Val Uncertain significance Single submitter
- DAPL1 p.Ala2Glu Uncertain significance Single submitter
- DAPL1 p.Ala50Val Uncertain significance Single submitter
- DAPL1 p.Ala62Asp Uncertain significance Single submitter
- DAPL1 p.Ala62Thr Uncertain significance Single submitter
- DAPL1 p.Ala66Glu Uncertain significance Single submitter
- DAPL1 p.Arg105Gln Uncertain significance Single submitter
- DAPL1 p.Arg12Gln Uncertain significance Single submitter
- DAPL1 p.Asp61Asn Uncertain significance Single submitter
- DAPL1 p.Glu46Lys Uncertain significance Single submitter
- DAPL1 p.Gly15Arg Uncertain significance Single submitter
- DAPL1 p.Gly34Ser Uncertain significance Single submitter
- DAPL1 p.His79Asp Uncertain significance Single submitter
- DAPL1 p.Ile57Thr Uncertain significance Single submitter
- DAPL1 p.Pro94Ala Uncertain significance Single submitter
- DAPL1 p.Tyr72Cys Uncertain significance Single submitter
- DAPL1 p.Val5Met Uncertain significance Single submitter
- DAPL1 p.Val92Ile Uncertain significance Single submitter
- DAPL1 p.Val93Asp Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All DAPL1 variants
Likely benign 2
- c.207+619A>G Single submitter
- c.207+625C>T Single submitter
Uncertain significance 22
- p.Ala19Pro Single submitter ⚠
- p.Ala22Val Single submitter ⚠
- p.Ala2Glu Single submitter ⚠
- p.Ala50Val Single submitter ⚠
- p.Ala62Asp Single submitter ⚠
- p.Ala62Thr Single submitter ⚠
- p.Ala66Glu Single submitter ⚠
- p.Arg105Gln Single submitter ⚠
- p.Arg12Gln Single submitter ⚠
- p.Asp61Asn Single submitter ⚠
- p.Glu46Lys Single submitter ⚠
- p.Gly15Arg Single submitter ⚠
- p.Gly34Ser Single submitter ⚠
- p.His79Asp Single submitter ⚠
- p.Ile57Thr Single submitter ⚠
- p.Leu67Pro Single submitter ⚠
- p.Lys21Ile Single submitter ⚠
- p.Pro94Ala Single submitter ⚠
- p.Tyr72Cys Single submitter ⚠
- p.Val5Met Single submitter ⚠
- p.Val92Ile Single submitter ⚠
- p.Val93Asp Single submitter ⚠