DAPP1 — 27 ClinVar variants
All ClinVar germline DAPP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 27 flagged for review →
27 Uncertain significance
Full DAPP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 27
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 16
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DAPP1 p.Ala215Thr Uncertain significance Single submitter
- DAPP1 p.Arg143Gln Uncertain significance Single submitter
- DAPP1 p.Asp15Asn Uncertain significance Single submitter
- DAPP1 p.Asp15Glu Uncertain significance Single submitter
- DAPP1 p.Asp219Asn Uncertain significance Single submitter
- DAPP1 p.Gln264Glu Uncertain significance Single submitter
- DAPP1 p.Glu26Asp Uncertain significance Single submitter
- DAPP1 p.Glu65Asp Uncertain significance Single submitter
- DAPP1 p.Gly120Asp Uncertain significance Single submitter
- DAPP1 p.Gly165Ala Uncertain significance Single submitter
- DAPP1 p.Leu40Phe Uncertain significance Single submitter
- DAPP1 p.Leu49His Uncertain significance Single submitter
- DAPP1 p.Ser100Leu Uncertain significance Single submitter
- DAPP1 p.Ser12Thr Uncertain significance Single submitter
- DAPP1 p.Thr146Ile Uncertain significance Single submitter
- DAPP1 p.Thr67Ile Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- DAPP1 p.Arg255His Uncertain significance Single submitter
- DAPP1 p.Arg262Ile Uncertain significance Single submitter
- DAPP1 p.Arg275Trp Uncertain significance Single submitter
- DAPP1 p.Gln260His Uncertain significance Single submitter
- DAPP1 p.Gly244Arg Uncertain significance Single submitter
- DAPP1 p.Gly38Ser Uncertain significance Single submitter
- DAPP1 p.Gly68Arg Uncertain significance Single submitter
- DAPP1 p.His43Gln Uncertain significance Single submitter
- DAPP1 p.Ile261Met Uncertain significance Single submitter
- DAPP1 p.Ser276Leu Uncertain significance Single submitter
-
DAPP1 p.Asp104Asn
Uncertain significance
No assertion criteria
DAPP1-related condition
All DAPP1 variants
Uncertain significance 27
- p.Ala215Thr Single submitter ⚠
- p.Arg143Gln Single submitter ⚠
- p.Arg255His Single submitter ⚠
- p.Arg262Ile Single submitter ⚠
- p.Arg275Trp Single submitter ⚠
- p.Asp15Asn Single submitter ⚠
- p.Asp15Glu Single submitter ⚠
- p.Asp219Asn Single submitter ⚠
- p.Gln260His Single submitter ⚠
- p.Gln264Glu Single submitter ⚠
- p.Glu26Asp Single submitter ⚠
- p.Glu65Asp Single submitter ⚠
- p.Gly120Asp Single submitter ⚠
- p.Gly165Ala Single submitter ⚠
- p.Gly244Arg Single submitter ⚠
- p.Gly38Ser Single submitter ⚠
- p.Gly68Arg Single submitter ⚠
- p.His43Gln Single submitter ⚠
- p.Ile261Met Single submitter ⚠
- p.Leu40Phe Single submitter ⚠
- p.Leu49His Single submitter ⚠
- p.Ser100Leu Single submitter ⚠
- p.Ser12Thr Single submitter ⚠
- p.Ser276Leu Single submitter ⚠
- p.Thr146Ile Single submitter ⚠
- p.Thr67Ile Single submitter ⚠
- p.Asp104Asn No assertion criteria DAPP1-related condition ⚠