DAXX — 84 ClinVar variants
All ClinVar germline DAXX variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 65 flagged for review →
3 Benign · 17 Likely benign · 64 Uncertain significance
Full DAXX gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 65
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 30
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DAXX p.Ala545Gly Uncertain significance Single submitter
- DAXX p.Ala79Val Uncertain significance Single submitter
- DAXX p.Arg230Leu Uncertain significance Single submitter
- DAXX p.Arg526His Uncertain significance Single submitter
- DAXX p.Asn128Ser Uncertain significance Single submitter
- DAXX p.Asn276Ser Uncertain significance Single submitter
- DAXX p.Asn504Ser Uncertain significance Single submitter
- DAXX p.Asn621Lys Uncertain significance Single submitter
- DAXX p.Asp414Asn Uncertain significance Single submitter
- DAXX p.Gln92His Uncertain significance Single submitter
- DAXX p.Glu209Lys Uncertain significance Single submitter
- DAXX p.Glu558Gln Uncertain significance Single submitter
- DAXX p.Glu570Gln Uncertain significance Single submitter
- DAXX p.Glu602Ala Uncertain significance Single submitter
- DAXX p.Gly400Arg Uncertain significance Single submitter
- DAXX p.Gly416Asp Uncertain significance Single submitter
- DAXX p.Gly473Ser Uncertain significance Single submitter
- DAXX p.Gly606Val Uncertain significance Single submitter
- DAXX p.Gly640Arg Uncertain significance Single submitter
- DAXX p.His163Pro Uncertain significance Single submitter
- DAXX p.His26Pro Uncertain significance Single submitter
- DAXX p.Leu191Trp Uncertain significance Single submitter
- DAXX p.Lys634Thr Uncertain significance Single submitter
- DAXX p.Pro168His Uncertain significance Single submitter
- DAXX p.Pro44Thr Uncertain significance Single submitter
- DAXX p.Pro537Leu Uncertain significance Single submitter
- DAXX p.Pro701Leu Uncertain significance Single submitter
- DAXX p.Ser102Leu Uncertain significance Single submitter
- DAXX p.Thr722Ile Uncertain significance Single submitter
- DAXX p.Tyr259Phe Uncertain significance Single submitter
Predictors split 35
The independent predictors disagree with each other — read with care.
- DAXX p.Ala103Val Uncertain significance Single submitter
- DAXX p.Ala396Val Uncertain significance Single submitter
- DAXX p.Arg115Gln Uncertain significance Single submitter
- DAXX p.Arg117Gln Likely benign Single submitter
- DAXX p.Arg203Gln Uncertain significance Single submitter
- DAXX p.Arg203Trp Uncertain significance Single submitter
- DAXX p.Arg230His Uncertain significance Single submitter
- DAXX p.Arg256Cys Uncertain significance Single submitter
- DAXX p.Arg299Gln Uncertain significance Single submitter
- DAXX p.Arg306Gly Uncertain significance Single submitter
- DAXX p.Arg362Trp Uncertain significance Single submitter
- DAXX p.Arg371Trp Uncertain significance Single submitter
- DAXX p.Arg705Trp Likely benign Single submitter
- DAXX p.Arg716Trp Uncertain significance Single submitter
- DAXX p.Asp12Gly Uncertain significance Single submitter
- DAXX p.Asp14Gly Uncertain significance Single submitter
- DAXX p.Asp216Gly Uncertain significance Single submitter
- DAXX p.Asp440Asn Uncertain significance Single submitter
- DAXX p.Asp440Tyr Uncertain significance Single submitter
- DAXX p.Asp80His Uncertain significance Single submitter
- DAXX p.Glu214Gln Uncertain significance Single submitter
- DAXX p.Glu445Asp Likely benign Single submitter
- DAXX p.Glu475Lys Uncertain significance Single submitter
- DAXX p.Gly287Glu Uncertain significance Single submitter
- DAXX p.Leu698Phe Uncertain significance Single submitter
- DAXX p.Pro82Leu Uncertain significance Single submitter
- DAXX p.Ser246Pro Uncertain significance Single submitter
- DAXX p.Ser415Phe Uncertain significance Single submitter
- DAXX p.Ser429Tyr Uncertain significance Single submitter
- DAXX p.Ser702Phe Likely benign Single submitter
- DAXX p.Ser707Phe Uncertain significance Single submitter
- DAXX p.Ser97Phe Uncertain significance Single submitter
- DAXX p.Thr162Ile Uncertain significance Single submitter
- DAXX p.Thr401Ile Uncertain significance Single submitter
- DAXX p.Val356Met Uncertain significance Single submitter
All DAXX variants
Benign 3
- p.Ala486Gly Single submitter
- p.Asp439= Single submitter
- p.Val375Ile Single submitter
Likely benign 17
- c.-84G>A Single submitter
- c.-86G>C Single submitter
- p.Arg117Gln Single submitter ⚠
- p.Arg653Lys Single submitter
- p.Arg705Gln Single submitter
- p.Arg705Trp Single submitter ⚠
- p.Cys664Arg Single submitter
- p.Gln308Arg Single submitter
- p.Glu445Asp Single submitter ⚠
- p.Ile527Met Single submitter
- p.Leu28Pro Single submitter
- p.Leu557Pro Single submitter
- p.Met497Thr Single submitter
- p.Pro409Ser Single submitter
- p.Pro672Ser Single submitter
- p.Ser702Phe Single submitter ⚠
- p.Val348Ile Single submitter
Uncertain significance 64
- c.-56T>C Single submitter
- c.-63C>T Single submitter
- c.-66A>G Single submitter
- p.Ala103Val Single submitter ⚠
- p.Ala396Val Single submitter ⚠
- p.Ala545Gly Single submitter ⚠
- p.Ala79Val Single submitter ⚠
- p.Arg115Gln Single submitter ⚠
- p.Arg203Gln Single submitter ⚠
- p.Arg203Trp Single submitter ⚠
- p.Arg230His Single submitter ⚠
- p.Arg230Leu Single submitter ⚠
- p.Arg256Cys Single submitter ⚠
- p.Arg299Gln Single submitter ⚠
- p.Arg306Gly Single submitter ⚠
- p.Arg362Trp Single submitter ⚠
- p.Arg371Trp Single submitter ⚠
- p.Arg526His Single submitter ⚠
- p.Arg716Trp Single submitter ⚠
- p.Asn128Ser Single submitter ⚠
- p.Asn276Ser Single submitter ⚠
- p.Asn504Ser Single submitter ⚠
- p.Asn621Lys Single submitter ⚠
- p.Asp12Gly Single submitter ⚠
- p.Asp14Gly Single submitter ⚠
- p.Asp216Gly Single submitter ⚠
- p.Asp414Asn Single submitter ⚠
- p.Asp440Asn Single submitter ⚠
- p.Asp440Tyr Single submitter ⚠
- p.Asp80His Single submitter ⚠
- p.Gln92His Single submitter ⚠
- p.Glu209Lys Single submitter ⚠
- p.Glu214Gln Single submitter ⚠
- p.Glu475Lys Single submitter ⚠
- p.Glu558Gln Single submitter ⚠
- p.Glu570Gln Single submitter ⚠
- p.Glu602Ala Single submitter ⚠
- p.Gly287Glu Single submitter ⚠
- p.Gly400Arg Single submitter ⚠
- p.Gly416Asp Single submitter ⚠
- p.Gly473Ser Single submitter ⚠
- p.Gly606Val Single submitter ⚠
- p.Gly640Arg Single submitter ⚠
- p.His163Pro Single submitter ⚠
- p.His26Pro Single submitter ⚠
- p.Leu191Trp Single submitter ⚠
- p.Leu698Phe Single submitter ⚠
- p.Lys634Thr Single submitter ⚠
- p.Pro168His Single submitter ⚠
- p.Pro44Thr Single submitter ⚠
- p.Pro537Leu Single submitter ⚠
- p.Pro701Leu Single submitter ⚠
- p.Pro82Leu Single submitter ⚠
- p.Ser102Leu Single submitter ⚠
- p.Ser246Pro Single submitter ⚠
- p.Ser415Phe Single submitter ⚠
- p.Ser429Tyr Single submitter ⚠
- p.Ser707Phe Single submitter ⚠
- p.Ser97Phe Single submitter ⚠
- p.Thr162Ile Single submitter ⚠
- p.Thr401Ile Single submitter ⚠
- p.Thr722Ile Single submitter ⚠
- p.Tyr259Phe Single submitter ⚠
- p.Val356Met Single submitter ⚠