DAZAP1 — 33 ClinVar variants
All ClinVar germline DAZAP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 30 flagged for review →
1 Benign · 32 Uncertain significance
Full DAZAP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 30
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 26
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DAZAP1 p.Ala214Thr Uncertain significance Single submitter
- DAZAP1 p.Ala242Thr Uncertain significance Single submitter
- DAZAP1 p.Ala251Gly Uncertain significance Single submitter
- DAZAP1 p.Ala255Val Uncertain significance Single submitter
- DAZAP1 p.Ala331Val Uncertain significance Single submitter
- DAZAP1 p.Ala340Thr Uncertain significance Single submitter
- DAZAP1 p.Arg88Trp Uncertain significance Single submitter
- DAZAP1 p.Asn3Ser Uncertain significance Single submitter
- DAZAP1 p.Asp108Asn Uncertain significance Single submitter
- DAZAP1 p.Asp365Glu Uncertain significance Single submitter
- DAZAP1 p.Gly100Ala Uncertain significance Single submitter
- DAZAP1 p.Gly285Ser Uncertain significance Single submitter
- DAZAP1 p.Gly34Ala Uncertain significance Single submitter
- DAZAP1 p.Gly387Ser Uncertain significance Single submitter
- DAZAP1 p.Gly388Ser Uncertain significance Single submitter
- DAZAP1 p.Met334Ile Uncertain significance Single submitter
- DAZAP1 p.Met334Val Uncertain significance Single submitter
- DAZAP1 p.Pro198Leu Uncertain significance Single submitter
- DAZAP1 p.Pro276Ala Uncertain significance Single submitter
- DAZAP1 p.Pro337Ser Uncertain significance Single submitter
- DAZAP1 p.Pro370Thr Uncertain significance Single submitter
- DAZAP1 p.Pro92Leu Uncertain significance Single submitter
- DAZAP1 p.Ser381Pro Uncertain significance Single submitter
- DAZAP1 p.Val237Leu Uncertain significance Single submitter
- DAZAP1 p.Val37Ile Uncertain significance Single submitter
-
DAZAP1 p.Tyr405His
Uncertain significance
No assertion criteria
Monoclonal B-Cell Lymphocytosis
Predictors split 4
The independent predictors disagree with each other — read with care.
All DAZAP1 variants
Benign 1
- p.Pro271= Multiple submitters
Uncertain significance 32
- c.404_414+26dup Single submitter
- p.Ala214Thr Single submitter ⚠
- p.Ala242Thr Single submitter ⚠
- p.Ala251Gly Single submitter ⚠
- p.Ala255Val Single submitter ⚠
- p.Ala331Val Single submitter ⚠
- p.Ala340Thr Single submitter ⚠
- p.Arg88Trp Single submitter ⚠
- p.Arg96Trp Single submitter ⚠
- p.Asn3Ser Single submitter ⚠
- p.Asp108Asn Single submitter ⚠
- p.Asp365Glu Single submitter ⚠
- p.Gly100Ala Single submitter ⚠
- p.Gly244Asp Single submitter ⚠
- p.Gly285Ser Single submitter ⚠
- p.Gly317Arg Single submitter ⚠
- p.Gly34Ala Single submitter ⚠
- p.Gly387Ser Single submitter ⚠
- p.Gly388Ser Single submitter ⚠
- p.Lys134Met Single submitter
- p.Met334Ile Single submitter ⚠
- p.Met334Val Single submitter ⚠
- p.Pro198Leu Single submitter ⚠
- p.Pro276Ala Single submitter ⚠
- p.Pro337Ser Single submitter ⚠
- p.Pro370Thr Single submitter ⚠
- p.Pro92Leu Single submitter ⚠
- p.Ser381Pro Single submitter ⚠
- p.Val142Leu Single submitter ⚠
- p.Val237Leu Single submitter ⚠
- p.Val37Ile Single submitter ⚠
- p.Tyr405His No assertion criteria Monoclonal B-Cell Lymphocytosis ⚠