DAZL — 43 ClinVar variants
All ClinVar germline DAZL variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 32 flagged for review →
1 Pathogenic · 1 Likely pathogenic · 7 Benign · 2 Likely benign · 32 Uncertain significance
Full DAZL gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 32
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 25
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DAZL p.Arg201Lys Uncertain significance Single submitter
- DAZL p.Arg250Gln Uncertain significance Single submitter
- DAZL p.Arg62Lys Uncertain significance Single submitter
- DAZL p.Asn102His Uncertain significance Single submitter
- DAZL p.Asn132Ser Uncertain significance Single submitter
- DAZL p.Asn217Asp Uncertain significance Single submitter
- DAZL p.Asn40Ser Uncertain significance Single submitter
- DAZL p.Asn5Ser Uncertain significance Single submitter
- DAZL p.Asp274Glu Uncertain significance Single submitter
- DAZL p.Asp274Gly Uncertain significance Single submitter
- DAZL p.Gly242Asp Uncertain significance Single submitter
- DAZL p.His133Arg Uncertain significance Single submitter
- DAZL p.His215Asn Uncertain significance Single submitter
- DAZL p.His233Arg Uncertain significance Single submitter
- DAZL p.Met191Leu Uncertain significance Single submitter
- DAZL p.Met191Val Uncertain significance Single submitter
- DAZL p.Met51Val Uncertain significance Single submitter
- DAZL p.Pro175Ala Uncertain significance Single submitter
- DAZL p.Pro193Ser Uncertain significance Single submitter
- DAZL p.Pro221Leu Uncertain significance Single submitter
- DAZL p.Thr156Ala Uncertain significance Single submitter
- DAZL p.Val178Phe Uncertain significance Single submitter
- DAZL p.Val271Ile Uncertain significance Single submitter
- DAZL p.Val282Met Uncertain significance Single submitter
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DAZL p.Thr54Ala
Uncertain significance
No assertion criteria
Reclassified - variant of unknown significance
Predictors split 7
The independent predictors disagree with each other — read with care.
- DAZL p.Asn10His Uncertain significance Single submitter
- DAZL p.Asn145Lys Uncertain significance Single submitter
- DAZL p.Gln183Arg Uncertain significance Single submitter
- DAZL p.Ile71Leu Uncertain significance Single submitter
- DAZL p.Ser2Pro Uncertain significance Single submitter
- DAZL p.Tyr203Cys Uncertain significance Single submitter
- DAZL p.Val165Ala Uncertain significance Single submitter
All DAZL variants
Pathogenic 1
- p.Asp74fs No assertion criteria Idiopathic male infertility
Likely pathogenic 1
- p.Val66Glu No assertion criteria Idiopathic male infertility
Benign 7
- c.3+717G>A No assertion criteria DAZL-related disorder
- c.571-4dup No assertion criteria DAZL-related disorder
- c.736-9G>A No assertion criteria DAZL-related disorder
- p.Glu55Asp No assertion criteria Idiopathic male infertility
- p.Pro135= No assertion criteria DAZL-related disorder
- p.Ser65Thr No assertion criteria Idiopathic male infertility
- p.Thr12Ala No assertion criteria DAZL-related disorder
Uncertain significance 32
- p.Arg201Lys Single submitter ⚠
- p.Arg250Gln Single submitter ⚠
- p.Arg62Lys Single submitter ⚠
- p.Asn102His Single submitter ⚠
- p.Asn10His Single submitter ⚠
- p.Asn132Ser Single submitter ⚠
- p.Asn145Lys Single submitter ⚠
- p.Asn217Asp Single submitter ⚠
- p.Asn40Ser Single submitter ⚠
- p.Asn5Ser Single submitter ⚠
- p.Asp274Glu Single submitter ⚠
- p.Asp274Gly Single submitter ⚠
- p.Gln183Arg Single submitter ⚠
- p.Gly242Asp Single submitter ⚠
- p.His133Arg Single submitter ⚠
- p.His215Asn Single submitter ⚠
- p.His233Arg Single submitter ⚠
- p.Ile71Leu Single submitter ⚠
- p.Met191Leu Single submitter ⚠
- p.Met191Val Single submitter ⚠
- p.Met51Val Single submitter ⚠
- p.Pro175Ala Single submitter ⚠
- p.Pro193Ser Single submitter ⚠
- p.Pro221Leu Single submitter ⚠
- p.Ser2Pro Single submitter ⚠
- p.Thr156Ala Single submitter ⚠
- p.Tyr203Cys Single submitter ⚠
- p.Val165Ala Single submitter ⚠
- p.Val178Phe Single submitter ⚠
- p.Val271Ile Single submitter ⚠
- p.Val282Met Single submitter ⚠
- p.Thr54Ala No assertion criteria Reclassified - variant of unknown significance ⚠