DBF4 — 83 ClinVar variants
All ClinVar germline DBF4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 77 flagged for review →
3 Benign · 3 Likely benign · 77 Uncertain significance
Full DBF4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 77
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 64
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DBF4 p.Arg101Gln Uncertain significance Single submitter
- DBF4 p.Arg214Lys Uncertain significance Single submitter
- DBF4 p.Arg26Gly Uncertain significance Single submitter
- DBF4 p.Arg576Gln Uncertain significance Single submitter
- DBF4 p.Arg599Gly Uncertain significance Single submitter
- DBF4 p.Asn317Ser Uncertain significance Single submitter
- DBF4 p.Asn36Asp Uncertain significance Single submitter
- DBF4 p.Asn608Ser Uncertain significance Single submitter
- DBF4 p.Asn654Asp Uncertain significance Single submitter
- DBF4 p.Asp124Gly Uncertain significance Single submitter
- DBF4 p.Asp256Val Uncertain significance Single submitter
- DBF4 p.Asp276Asn Uncertain significance Single submitter
- DBF4 p.Asp35His Uncertain significance Single submitter
- DBF4 p.Asp384His Uncertain significance Single submitter
- DBF4 p.Asp388Ala Uncertain significance Single submitter
- DBF4 p.Asp388His Uncertain significance Single submitter
- DBF4 p.Cys250Tyr Uncertain significance Single submitter
- DBF4 p.Cys484Arg Uncertain significance Single submitter
- DBF4 p.Cys644Tyr Uncertain significance Single submitter
- DBF4 p.Gln227Lys Uncertain significance Single submitter
- DBF4 p.Gln266Glu Uncertain significance Single submitter
- DBF4 p.Gln382Arg Uncertain significance Single submitter
- DBF4 p.Gln446Arg Uncertain significance Single submitter
- DBF4 p.Gln540Lys Uncertain significance Single submitter
- DBF4 p.Glu466Lys Uncertain significance Single submitter
- DBF4 p.Gly206Asp Uncertain significance Single submitter
- DBF4 p.Gly279Arg Uncertain significance Single submitter
- DBF4 p.His13Tyr Uncertain significance Single submitter
- DBF4 p.His418Asp Uncertain significance Single submitter
- DBF4 p.His524Arg Uncertain significance Single submitter
- DBF4 p.His529Pro Uncertain significance Single submitter
- DBF4 p.His529Tyr Uncertain significance Single submitter
- DBF4 p.Ile351Val Uncertain significance Single submitter
- DBF4 p.Ile534Met Uncertain significance Single submitter
- DBF4 p.Ile60Thr Uncertain significance Single submitter
- DBF4 p.Leu358Phe Uncertain significance Single submitter
- DBF4 p.Leu618Phe Uncertain significance Single submitter
- DBF4 p.Lys190Glu Uncertain significance Single submitter
- DBF4 p.Lys33Glu Uncertain significance Single submitter
- DBF4 p.Lys368Arg Uncertain significance Single submitter
- DBF4 p.Lys519Thr Uncertain significance Single submitter
- DBF4 p.Lys564Glu Uncertain significance Single submitter
- DBF4 p.Lys577Arg Uncertain significance Single submitter
- DBF4 p.Lys598Glu Uncertain significance Single submitter
- DBF4 p.Met225Thr Uncertain significance Single submitter
- DBF4 p.Met225Val Uncertain significance Single submitter
- DBF4 p.Phe397Cys Uncertain significance Single submitter
- DBF4 p.Phe51Leu Uncertain significance Single submitter
- DBF4 p.Pro106Gln Uncertain significance Single submitter
- DBF4 p.Pro108Arg Uncertain significance Single submitter
- DBF4 p.Pro417Arg Uncertain significance Single submitter
- DBF4 p.Pro550Ser Uncertain significance Single submitter
- DBF4 p.Pro558Ser Uncertain significance Single submitter
- DBF4 p.Ser28Phe Uncertain significance Single submitter
- DBF4 p.Ser636Gly Uncertain significance Single submitter
- DBF4 p.Ser80Arg Uncertain significance Single submitter
- DBF4 p.Thr439Ile Uncertain significance Single submitter
- DBF4 p.Thr468Ser Uncertain significance Single submitter
- DBF4 p.Thr528Ile Uncertain significance Single submitter
- DBF4 p.Thr553Ile Uncertain significance Single submitter
- DBF4 p.Thr670Ile Uncertain significance Single submitter
- DBF4 p.Trp47Cys Uncertain significance Single submitter
- DBF4 p.Val267Ala Uncertain significance Single submitter
- DBF4 p.Val375Met Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- DBF4 p.Ala661Val Uncertain significance Single submitter
- DBF4 p.Asn421Tyr Uncertain significance Single submitter
- DBF4 p.Asp254Glu Uncertain significance Single submitter
- DBF4 p.Asp509Tyr Uncertain significance Single submitter
- DBF4 p.Leu215Phe Uncertain significance Single submitter
- DBF4 p.Leu632Trp Uncertain significance Single submitter
- DBF4 p.Lys400Arg Uncertain significance Single submitter
- DBF4 p.Ser259Phe Uncertain significance Single submitter
- DBF4 p.Ser31Phe Uncertain significance Single submitter
- DBF4 p.Ser664Leu Uncertain significance Single submitter
- DBF4 p.Thr133Ile Uncertain significance Single submitter
- DBF4 p.Thr660Ile Uncertain significance Single submitter
- DBF4 p.Val392Met Uncertain significance Single submitter
All DBF4 variants
Benign 3
- p.Ile18= Multiple submitters
- p.Lys579Glu Multiple submitters
- p.Ile526Val Single submitter
Likely benign 3
- p.Cys385Phe Single submitter
- p.Glu394Lys Single submitter
- p.Ser438Asn Single submitter
Uncertain significance 77
- p.Ala661Val Single submitter ⚠
- p.Arg101Gln Single submitter ⚠
- p.Arg214Lys Single submitter ⚠
- p.Arg26Gly Single submitter ⚠
- p.Arg576Gln Single submitter ⚠
- p.Arg599Gly Single submitter ⚠
- p.Asn317Ser Single submitter ⚠
- p.Asn36Asp Single submitter ⚠
- p.Asn421Tyr Single submitter ⚠
- p.Asn608Ser Single submitter ⚠
- p.Asn654Asp Single submitter ⚠
- p.Asp124Gly Single submitter ⚠
- p.Asp254Glu Single submitter ⚠
- p.Asp256Val Single submitter ⚠
- p.Asp276Asn Single submitter ⚠
- p.Asp35His Single submitter ⚠
- p.Asp384His Single submitter ⚠
- p.Asp388Ala Single submitter ⚠
- p.Asp388His Single submitter ⚠
- p.Asp509Tyr Single submitter ⚠
- p.Cys250Tyr Single submitter ⚠
- p.Cys484Arg Single submitter ⚠
- p.Cys644Tyr Single submitter ⚠
- p.Gln227Lys Single submitter ⚠
- p.Gln266Glu Single submitter ⚠
- p.Gln382Arg Single submitter ⚠
- p.Gln446Arg Single submitter ⚠
- p.Gln540Lys Single submitter ⚠
- p.Glu466Lys Single submitter ⚠
- p.Gly206Asp Single submitter ⚠
- p.Gly279Arg Single submitter ⚠
- p.His13Tyr Single submitter ⚠
- p.His418Asp Single submitter ⚠
- p.His524Arg Single submitter ⚠
- p.His529Pro Single submitter ⚠
- p.His529Tyr Single submitter ⚠
- p.Ile351Val Single submitter ⚠
- p.Ile534Met Single submitter ⚠
- p.Ile60Thr Single submitter ⚠
- p.Leu215Phe Single submitter ⚠
- p.Leu358Phe Single submitter ⚠
- p.Leu618Phe Single submitter ⚠
- p.Leu632Trp Single submitter ⚠
- p.Lys190Glu Single submitter ⚠
- p.Lys33Glu Single submitter ⚠
- p.Lys368Arg Single submitter ⚠
- p.Lys400Arg Single submitter ⚠
- p.Lys519Thr Single submitter ⚠
- p.Lys564Glu Single submitter ⚠
- p.Lys577Arg Single submitter ⚠
- p.Lys598Glu Single submitter ⚠
- p.Met225Thr Single submitter ⚠
- p.Met225Val Single submitter ⚠
- p.Phe397Cys Single submitter ⚠
- p.Phe51Leu Single submitter ⚠
- p.Pro106Gln Single submitter ⚠
- p.Pro108Arg Single submitter ⚠
- p.Pro417Arg Single submitter ⚠
- p.Pro550Ser Single submitter ⚠
- p.Pro558Ser Single submitter ⚠
- p.Ser259Phe Single submitter ⚠
- p.Ser28Phe Single submitter ⚠
- p.Ser31Phe Single submitter ⚠
- p.Ser636Gly Single submitter ⚠
- p.Ser664Leu Single submitter ⚠
- p.Ser80Arg Single submitter ⚠
- p.Thr133Ile Single submitter ⚠
- p.Thr439Ile Single submitter ⚠
- p.Thr468Ser Single submitter ⚠
- p.Thr528Ile Single submitter ⚠
- p.Thr553Ile Single submitter ⚠
- p.Thr660Ile Single submitter ⚠
- p.Thr670Ile Single submitter ⚠
- p.Trp47Cys Single submitter ⚠
- p.Val267Ala Single submitter ⚠
- p.Val375Met Single submitter ⚠
- p.Val392Met Single submitter ⚠