DBF4B — 77 ClinVar variants
All ClinVar germline DBF4B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 74 flagged for review →
5 Likely benign · 72 Uncertain significance
Full DBF4B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 74
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 52
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DBF4B p.Ala197Val Uncertain significance Single submitter
- DBF4B p.Ala331Val Uncertain significance Single submitter
- DBF4B p.Ala361Thr Uncertain significance Single submitter
- DBF4B p.Ala383Thr Uncertain significance Single submitter
- DBF4B p.Ala499Ser Uncertain significance Single submitter
- DBF4B p.Arg131Ser Uncertain significance Single submitter
- DBF4B p.Arg221Gln Uncertain significance Single submitter
- DBF4B p.Arg287Gln Uncertain significance Single submitter
- DBF4B p.Arg296Lys Uncertain significance Single submitter
- DBF4B p.Arg407Gln Uncertain significance Single submitter
- DBF4B p.Arg511Cys Uncertain significance Single submitter
- DBF4B p.Asp334Gly Uncertain significance Single submitter
- DBF4B p.Asp413His Uncertain significance Single submitter
- DBF4B p.Asp8Glu Uncertain significance Single submitter
- DBF4B p.Glu14Lys Uncertain significance Single submitter
- DBF4B p.Glu19Gln Uncertain significance Single submitter
- DBF4B p.Gly106Val Uncertain significance Single submitter
- DBF4B p.Gly127Arg Uncertain significance Single submitter
- DBF4B p.Gly161Arg Uncertain significance Single submitter
- DBF4B p.Gly178Val Uncertain significance Single submitter
- DBF4B p.Gly358Asp Uncertain significance Single submitter
- DBF4B p.His455Arg Uncertain significance Single submitter
- DBF4B p.Ile567Met Uncertain significance Single submitter
- DBF4B p.Leu372Val Uncertain significance Single submitter
- DBF4B p.Leu587Val Uncertain significance Single submitter
- DBF4B p.Leu81Pro Uncertain significance Single submitter
- DBF4B p.Lys38Gln Uncertain significance Single submitter
- DBF4B p.Met17Val Uncertain significance Single submitter
- DBF4B p.Pro214Leu Uncertain significance Single submitter
- DBF4B p.Pro25Arg Uncertain significance Single submitter
- DBF4B p.Pro267Gln Uncertain significance Single submitter
- DBF4B p.Pro284Leu Uncertain significance Single submitter
- DBF4B p.Pro366Leu Uncertain significance Single submitter
- DBF4B p.Pro418Leu Uncertain significance Single submitter
- DBF4B p.Pro432Leu Uncertain significance Single submitter
- DBF4B p.Pro432Ser Uncertain significance Single submitter
- DBF4B p.Ser168Asn Uncertain significance Single submitter
- DBF4B p.Ser16Pro Uncertain significance Single submitter
- DBF4B p.Ser322Arg Uncertain significance Single submitter
- DBF4B p.Ser322Asn Uncertain significance Single submitter
- DBF4B p.Thr517Ile Uncertain significance Single submitter
- DBF4B p.Thr575Ser Uncertain significance Single submitter
- DBF4B p.Trp408Arg Uncertain significance Single submitter
- DBF4B p.Trp518Cys Uncertain significance Single submitter
- DBF4B p.Tyr581Cys Uncertain significance Single submitter
- DBF4B p.Val115Ile Uncertain significance Single submitter
- DBF4B p.Val137Ala Uncertain significance Single submitter
- DBF4B p.Val223Ala Uncertain significance Single submitter
- DBF4B p.Val556Leu Uncertain significance Single submitter
- DBF4B p.Val558Leu Uncertain significance Single submitter
- DBF4B p.Val612Gly Uncertain significance Single submitter
- DBF4B p.Val85Ile Uncertain significance Single submitter
Predictors split 22
The independent predictors disagree with each other — read with care.
- DBF4B p.Val89Met Uncertain significance Multiple submitters
- DBF4B p.Ala69Thr Uncertain significance Single submitter
- DBF4B p.Arg144Lys Uncertain significance Single submitter
- DBF4B p.Arg221Trp Uncertain significance Single submitter
- DBF4B p.Arg321Trp Uncertain significance Single submitter
- DBF4B p.Arg92Cys Uncertain significance Single submitter
- DBF4B p.Arg92His Uncertain significance Single submitter
- DBF4B p.Arg92Leu Uncertain significance Single submitter
- DBF4B p.Gly166Asp Uncertain significance Single submitter
- DBF4B p.Leu544Ile Uncertain significance Single submitter
- DBF4B p.Leu548Phe Uncertain significance Single submitter
- DBF4B p.Lys83Arg Uncertain significance Single submitter
- DBF4B p.Met187Ile Uncertain significance Single submitter
- DBF4B p.Met187Thr Uncertain significance Single submitter
- DBF4B p.Ser143Asn Uncertain significance Single submitter
- DBF4B p.Ser438Phe Uncertain significance Single submitter
- DBF4B p.Thr268Met Uncertain significance Single submitter
- DBF4B p.Thr67Met Uncertain significance Single submitter
- DBF4B p.Val137Ile Likely benign Single submitter
- DBF4B p.Val184Met Uncertain significance Single submitter
- DBF4B p.Val191Met Likely benign Single submitter
- DBF4B p.Val516Met Uncertain significance Single submitter
All DBF4B variants
Likely benign 5
- p.Arg321Gln Single submitter
- p.Cys32Tyr Single submitter
- p.Tyr545His Single submitter
- p.Val137Ile Single submitter ⚠
- p.Val191Met Single submitter ⚠
Uncertain significance 72
- p.Val89Met Multiple submitters ⚠
- p.Ala197Val Single submitter ⚠
- p.Ala331Val Single submitter ⚠
- p.Ala361Thr Single submitter ⚠
- p.Ala383Thr Single submitter ⚠
- p.Ala499Ser Single submitter ⚠
- p.Ala69Thr Single submitter ⚠
- p.Arg131Ser Single submitter ⚠
- p.Arg144Lys Single submitter ⚠
- p.Arg221Gln Single submitter ⚠
- p.Arg221Trp Single submitter ⚠
- p.Arg287Gln Single submitter ⚠
- p.Arg296Lys Single submitter ⚠
- p.Arg321Trp Single submitter ⚠
- p.Arg407Gln Single submitter ⚠
- p.Arg511Cys Single submitter ⚠
- p.Arg92Cys Single submitter ⚠
- p.Arg92His Single submitter ⚠
- p.Arg92Leu Single submitter ⚠
- p.Asp334Gly Single submitter ⚠
- p.Asp413His Single submitter ⚠
- p.Asp8Glu Single submitter ⚠
- p.Glu14Lys Single submitter ⚠
- p.Glu19Gln Single submitter ⚠
- p.Gly106Val Single submitter ⚠
- p.Gly127Arg Single submitter ⚠
- p.Gly161Arg Single submitter ⚠
- p.Gly166Asp Single submitter ⚠
- p.Gly178Val Single submitter ⚠
- p.Gly358Asp Single submitter ⚠
- p.His455Arg Single submitter ⚠
- p.Ile567Met Single submitter ⚠
- p.Leu372Val Single submitter ⚠
- p.Leu544Ile Single submitter ⚠
- p.Leu548Phe Single submitter ⚠
- p.Leu587Val Single submitter ⚠
- p.Leu81Pro Single submitter ⚠
- p.Lys38Gln Single submitter ⚠
- p.Lys83Arg Single submitter ⚠
- p.Met17Val Single submitter ⚠
- p.Met187Ile Single submitter ⚠
- p.Met187Thr Single submitter ⚠
- p.Pro214Leu Single submitter ⚠
- p.Pro25Arg Single submitter ⚠
- p.Pro267Gln Single submitter ⚠
- p.Pro284Leu Single submitter ⚠
- p.Pro366Leu Single submitter ⚠
- p.Pro418Leu Single submitter ⚠
- p.Pro432Leu Single submitter ⚠
- p.Pro432Ser Single submitter ⚠
- p.Ser143Asn Single submitter ⚠
- p.Ser168Asn Single submitter ⚠
- p.Ser16Pro Single submitter ⚠
- p.Ser322Arg Single submitter ⚠
- p.Ser322Asn Single submitter ⚠
- p.Ser438Phe Single submitter ⚠
- p.Thr268Met Single submitter ⚠
- p.Thr517Ile Single submitter ⚠
- p.Thr575Ser Single submitter ⚠
- p.Thr67Met Single submitter ⚠
- p.Trp408Arg Single submitter ⚠
- p.Trp518Cys Single submitter ⚠
- p.Tyr581Cys Single submitter ⚠
- p.Val115Ile Single submitter ⚠
- p.Val137Ala Single submitter ⚠
- p.Val184Met Single submitter ⚠
- p.Val223Ala Single submitter ⚠
- p.Val516Met Single submitter ⚠
- p.Val556Leu Single submitter ⚠
- p.Val558Leu Single submitter ⚠
- p.Val612Gly Single submitter ⚠
- p.Val85Ile Single submitter ⚠