DBI — 11 ClinVar variants
All ClinVar germline DBI variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 11 flagged for review →
1 Benign · 10 Uncertain significance
Full DBI gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 11
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 2
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 9
The independent predictors disagree with each other — read with care.
- DBI p.Ala35Val Uncertain significance Single submitter
- DBI p.Arg14Ser Uncertain significance Single submitter
- DBI p.Arg44Trp Uncertain significance Single submitter
- DBI p.Asp57Gly Uncertain significance Single submitter
- DBI p.Glu24Gln Uncertain significance Single submitter
- DBI p.Gly64Ala Uncertain significance Single submitter
- DBI p.Gly86Arg Benign Single submitter
- DBI p.Ile28Met Uncertain significance Single submitter
- DBI p.Lys67Arg Uncertain significance Single submitter
All DBI variants
Benign 1
- p.Gly86Arg Single submitter ⚠
Uncertain significance 10
- p.Ala35Val Single submitter ⚠
- p.Arg14Ser Single submitter ⚠
- p.Arg44Trp Single submitter ⚠
- p.Asp57Gly Single submitter ⚠
- p.Glu24Gln Single submitter ⚠
- p.Gly64Ala Single submitter ⚠
- p.Ile28Met Single submitter ⚠
- p.Ile40Arg Single submitter ⚠
- p.Lys67Arg Single submitter ⚠
- p.Thr51Met Single submitter ⚠