DBNDD1 — 36 ClinVar variants
All ClinVar germline DBNDD1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 30 flagged for review →
3 Likely benign · 33 Uncertain significance
Full DBNDD1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 30
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 27
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DBNDD1 p.Ala143Thr Uncertain significance Single submitter
- DBNDD1 p.Ala27Thr Uncertain significance Single submitter
- DBNDD1 p.Arg113Gln Uncertain significance Single submitter
- DBNDD1 p.Arg118His Uncertain significance Single submitter
- DBNDD1 p.Arg141Gln Uncertain significance Single submitter
- DBNDD1 p.Asp138Asn Uncertain significance Single submitter
- DBNDD1 p.Asp158Ala Uncertain significance Single submitter
- DBNDD1 p.Gln129Glu Uncertain significance Single submitter
- DBNDD1 p.Glu132Gly Uncertain significance Single submitter
- DBNDD1 p.Glu132Lys Uncertain significance Single submitter
- DBNDD1 p.Glu140Gln Uncertain significance Single submitter
- DBNDD1 p.Glu15Asp Uncertain significance Single submitter
- DBNDD1 p.Glu15Lys Uncertain significance Single submitter
- DBNDD1 p.Glu40Asp Uncertain significance Single submitter
- DBNDD1 p.Glu41Gln Uncertain significance Single submitter
- DBNDD1 p.Glu98Asp Uncertain significance Single submitter
- DBNDD1 p.Gly115Ser Uncertain significance Single submitter
- DBNDD1 p.Gly24Arg Uncertain significance Single submitter
- DBNDD1 p.Pro48Gln Uncertain significance Single submitter
- DBNDD1 p.Pro48Leu Uncertain significance Single submitter
- DBNDD1 p.Pro50Leu Uncertain significance Single submitter
- DBNDD1 p.Thr148Met Uncertain significance Single submitter
- DBNDD1 p.Thr36Met Uncertain significance Single submitter
- DBNDD1 p.Thr56Met Uncertain significance Single submitter
- DBNDD1 p.Val25Ile Uncertain significance Single submitter
- DBNDD1 p.Val47Gly Uncertain significance Single submitter
- DBNDD1 p.Val65Ile Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All DBNDD1 variants
Likely benign 3
- p.Asn33Ser Single submitter
- p.His131= Single submitter
- p.Pro19Leu Single submitter
Uncertain significance 33
- c.32-545G>A Single submitter
- c.32-547C>T Single submitter
- c.32-548G>A Single submitter
- p.Ala143Thr Single submitter ⚠
- p.Ala27Thr Single submitter ⚠
- p.Arg113Gln Single submitter ⚠
- p.Arg118His Single submitter ⚠
- p.Arg141Gln Single submitter ⚠
- p.Asp138Asn Single submitter ⚠
- p.Asp158Ala Single submitter ⚠
- p.Asp94Glu Single submitter ⚠
- p.Gln129Glu Single submitter ⚠
- p.Glu132Gly Single submitter ⚠
- p.Glu132Lys Single submitter ⚠
- p.Glu140Gln Single submitter ⚠
- p.Glu15Asp Single submitter ⚠
- p.Glu15Lys Single submitter ⚠
- p.Glu40Asp Single submitter ⚠
- p.Glu41Gln Single submitter ⚠
- p.Glu98Asp Single submitter ⚠
- p.Gly115Ser Single submitter ⚠
- p.Gly24Arg Single submitter ⚠
- p.Leu53Pro Single submitter ⚠
- p.Pro48Gln Single submitter ⚠
- p.Pro48Leu Single submitter ⚠
- p.Pro50Leu Single submitter ⚠
- p.Ser84Leu Single submitter ⚠
- p.Thr148Met Single submitter ⚠
- p.Thr36Met Single submitter ⚠
- p.Thr56Met Single submitter ⚠
- p.Val25Ile Single submitter ⚠
- p.Val47Gly Single submitter ⚠
- p.Val65Ile Single submitter ⚠