DBNDD2 — 53 ClinVar variants
All ClinVar germline DBNDD2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 44 flagged for review →
3 Likely benign · 50 Uncertain significance
Full DBNDD2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 44
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 30
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DBNDD2 c.-29G>T Uncertain significance Single submitter
- DBNDD2 c.-32C>T Uncertain significance Single submitter
- DBNDD2 c.-5C>T Uncertain significance Single submitter
- DBNDD2 c.-69G>C Uncertain significance Single submitter
- DBNDD2 p.Ala137Gly Uncertain significance Single submitter
- DBNDD2 p.Ala26Thr Uncertain significance Single submitter
- DBNDD2 p.Ala8Ser Uncertain significance Single submitter
- DBNDD2 p.Arg19Trp Uncertain significance Single submitter
- DBNDD2 p.Arg30Leu Uncertain significance Single submitter
- DBNDD2 p.Asn126Lys Uncertain significance Single submitter
- DBNDD2 p.Asp109Asn Uncertain significance Single submitter
- DBNDD2 p.Asp122Ala Uncertain significance Single submitter
- DBNDD2 p.Asp122Asn Uncertain significance Single submitter
- DBNDD2 p.Gln143Lys Uncertain significance Single submitter
- DBNDD2 p.Glu24Lys Uncertain significance Single submitter
- DBNDD2 p.Glu43Gln Uncertain significance Single submitter
- DBNDD2 p.Gly158Ala Uncertain significance Single submitter
- DBNDD2 p.Gly19Arg Uncertain significance Single submitter
- DBNDD2 p.Gly52Ala Uncertain significance Single submitter
- DBNDD2 p.His39Asp Uncertain significance Single submitter
- DBNDD2 p.Leu101Pro Uncertain significance Single submitter
- DBNDD2 p.Leu10Ser Uncertain significance Single submitter
- DBNDD2 p.Leu10Trp Uncertain significance Single submitter
- DBNDD2 p.Leu45Pro Uncertain significance Single submitter
- DBNDD2 p.Leu98Val Uncertain significance Single submitter
- DBNDD2 p.Met94Thr Uncertain significance Single submitter
- DBNDD2 p.Pro132Ala Uncertain significance Single submitter
- DBNDD2 p.Ser144Leu Uncertain significance Single submitter
- DBNDD2 p.Thr115Asn Uncertain significance Single submitter
- DBNDD2 p.Thr61Ile Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- DBNDD2 c.-15C>A Uncertain significance Single submitter
- DBNDD2 c.-5C>A Uncertain significance Single submitter
- DBNDD2 c.-77C>A Uncertain significance Single submitter
- DBNDD2 p.Arg15Cys Uncertain significance Single submitter
- DBNDD2 p.Arg47Cys Uncertain significance Single submitter
- DBNDD2 p.Arg49Gly Uncertain significance Single submitter
- DBNDD2 p.Arg49Trp Uncertain significance Single submitter
- DBNDD2 p.Asp122Tyr Uncertain significance Single submitter
- DBNDD2 p.Glu43Lys Uncertain significance Single submitter
- DBNDD2 p.Leu16Phe Uncertain significance Single submitter
- DBNDD2 p.Leu37Phe Uncertain significance Single submitter
- DBNDD2 p.Pro51Ser Uncertain significance Single submitter
- DBNDD2 p.Thr139Met Uncertain significance Single submitter
- DBNDD2 p.Thr88Ile Uncertain significance Single submitter
All DBNDD2 variants
Likely benign 3
- c.-125C>T Single submitter
- p.Arg25Gly Single submitter
- p.Pro13Arg Single submitter
Uncertain significance 50
- c.78G>T Single submitter
- c.95C>A Single submitter
- c.-146C>T Single submitter
- c.-15C>A Single submitter ⚠
- c.-29G>T Single submitter ⚠
- c.-32C>T Single submitter ⚠
- c.-5C>A Single submitter ⚠
- c.-5C>T Single submitter ⚠
- c.-69G>C Single submitter ⚠
- c.-77C>A Single submitter ⚠
- p.Ala137Gly Single submitter ⚠
- p.Ala26Thr Single submitter ⚠
- p.Ala8Ser Single submitter ⚠
- p.Arg15Cys Single submitter ⚠
- p.Arg19Trp Single submitter ⚠
- p.Arg30Leu Single submitter ⚠
- p.Arg47Cys Single submitter ⚠
- p.Arg49Gly Single submitter ⚠
- p.Arg49Trp Single submitter ⚠
- p.Asn126Lys Single submitter ⚠
- p.Asp109Asn Single submitter ⚠
- p.Asp122Ala Single submitter ⚠
- p.Asp122Asn Single submitter ⚠
- p.Asp122Tyr Single submitter ⚠
- p.Gln143Lys Single submitter ⚠
- p.Glu24Lys Single submitter ⚠
- p.Glu43Gln Single submitter ⚠
- p.Glu43Lys Single submitter ⚠
- p.Gly158Ala Single submitter ⚠
- p.Gly19Arg Single submitter ⚠
- p.Gly52Ala Single submitter ⚠
- p.His39Asp Single submitter ⚠
- p.Leu101Pro Single submitter ⚠
- p.Leu10Ser Single submitter ⚠
- p.Leu10Trp Single submitter ⚠
- p.Leu16Phe Single submitter ⚠
- p.Leu37Phe Single submitter ⚠
- p.Leu45Pro Single submitter ⚠
- p.Leu98Val Single submitter ⚠
- p.Met94Thr Single submitter ⚠
- p.Pro132Ala Single submitter ⚠
- p.Pro51Ser Single submitter ⚠
- p.Ser144Leu Single submitter ⚠
- p.Ser28Asn Single submitter
- p.Thr115Asn Single submitter ⚠
- p.Thr139Met Single submitter ⚠
- p.Thr61Ile Single submitter ⚠
- p.Thr88Ile Single submitter ⚠
- p.Trp27Arg Single submitter
- p.Trp4Cys Single submitter