DBX1 — 41 ClinVar variants
All ClinVar germline DBX1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 40 flagged for review →
1 Likely benign · 40 Uncertain significance
Full DBX1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 40
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 27
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DBX1 p.Ala127Pro Uncertain significance Single submitter
- DBX1 p.Ala127Val Uncertain significance Single submitter
- DBX1 p.Ala314Thr Uncertain significance Single submitter
- DBX1 p.Arg211Leu Uncertain significance Single submitter
- DBX1 p.Arg237Trp Uncertain significance Single submitter
- DBX1 p.Arg49Pro Uncertain significance Single submitter
- DBX1 p.Arg56Ser Uncertain significance Single submitter
- DBX1 p.Arg67Thr Uncertain significance Single submitter
- DBX1 p.Asp222Glu Uncertain significance Single submitter
- DBX1 p.Asp302Asn Uncertain significance Single submitter
- DBX1 p.Asp324Ala Uncertain significance Single submitter
- DBX1 p.Asp324Val Uncertain significance Single submitter
- DBX1 p.Gln203His Uncertain significance Single submitter
- DBX1 p.Gly307Arg Uncertain significance Single submitter
- DBX1 p.Leu245Arg Uncertain significance Single submitter
- DBX1 p.Leu6Pro Uncertain significance Single submitter
- DBX1 p.Lys271Arg Uncertain significance Single submitter
- DBX1 p.Phe137Val Uncertain significance Single submitter
- DBX1 p.Pro256Ser Uncertain significance Single submitter
- DBX1 p.Pro311Ser Uncertain significance Single submitter
- DBX1 p.Pro311Thr Uncertain significance Single submitter
- DBX1 p.Pro9Thr Uncertain significance Single submitter
- DBX1 p.Ser48Arg Uncertain significance Single submitter
- DBX1 p.Ser80Leu Uncertain significance Single submitter
- DBX1 p.Ser89Arg Uncertain significance Single submitter
- DBX1 p.Thr136Ser Uncertain significance Single submitter
- DBX1 p.Thr72Lys Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- DBX1 p.Ala314Val Uncertain significance Single submitter
- DBX1 p.Glu276Ala Uncertain significance Single submitter
- DBX1 p.Glu335Asp Uncertain significance Single submitter
- DBX1 p.Gly320Arg Uncertain significance Single submitter
- DBX1 p.His299Tyr Uncertain significance Single submitter
- DBX1 p.Phe325Leu Uncertain significance Single submitter
- DBX1 p.Pro171Thr Uncertain significance Single submitter
- DBX1 p.Pro273His Uncertain significance Single submitter
- DBX1 p.Pro4His Uncertain significance Single submitter
- DBX1 p.Pro85Leu Uncertain significance Single submitter
- DBX1 p.Ser117Phe Uncertain significance Single submitter
- DBX1 p.Ser246Cys Uncertain significance Single submitter
- DBX1 p.Ser318Cys Uncertain significance Single submitter
All DBX1 variants
Likely benign 1
- p.Leu245= Single submitter
Uncertain significance 40
- p.Ala127Pro Single submitter ⚠
- p.Ala127Val Single submitter ⚠
- p.Ala314Thr Single submitter ⚠
- p.Ala314Val Single submitter ⚠
- p.Arg211Leu Single submitter ⚠
- p.Arg237Trp Single submitter ⚠
- p.Arg49Pro Single submitter ⚠
- p.Arg56Ser Single submitter ⚠
- p.Arg67Thr Single submitter ⚠
- p.Asp222Glu Single submitter ⚠
- p.Asp302Asn Single submitter ⚠
- p.Asp324Ala Single submitter ⚠
- p.Asp324Val Single submitter ⚠
- p.Gln203His Single submitter ⚠
- p.Glu276Ala Single submitter ⚠
- p.Glu335Asp Single submitter ⚠
- p.Gly307Arg Single submitter ⚠
- p.Gly320Arg Single submitter ⚠
- p.His299Tyr Single submitter ⚠
- p.Leu245Arg Single submitter ⚠
- p.Leu6Pro Single submitter ⚠
- p.Lys271Arg Single submitter ⚠
- p.Phe137Val Single submitter ⚠
- p.Phe325Leu Single submitter ⚠
- p.Pro171Thr Single submitter ⚠
- p.Pro256Ser Single submitter ⚠
- p.Pro273His Single submitter ⚠
- p.Pro311Ser Single submitter ⚠
- p.Pro311Thr Single submitter ⚠
- p.Pro4His Single submitter ⚠
- p.Pro85Leu Single submitter ⚠
- p.Pro9Thr Single submitter ⚠
- p.Ser117Phe Single submitter ⚠
- p.Ser246Cys Single submitter ⚠
- p.Ser318Cys Single submitter ⚠
- p.Ser48Arg Single submitter ⚠
- p.Ser80Leu Single submitter ⚠
- p.Ser89Arg Single submitter ⚠
- p.Thr136Ser Single submitter ⚠
- p.Thr72Lys Single submitter ⚠