DBX2 — 67 ClinVar variants
All ClinVar germline DBX2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 63 flagged for review →
1 Benign · 3 Likely benign · 63 Uncertain significance
Full DBX2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 63
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 54
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DBX2 p.Ala104Val Uncertain significance Single submitter
- DBX2 p.Ala10Gly Uncertain significance Single submitter
- DBX2 p.Ala12Gly Uncertain significance Single submitter
- DBX2 p.Ala150Thr Uncertain significance Single submitter
- DBX2 p.Ala21Pro Uncertain significance Single submitter
- DBX2 p.Ala309Thr Uncertain significance Single submitter
- DBX2 p.Ala8Val Uncertain significance Single submitter
- DBX2 p.Arg158Cys Uncertain significance Single submitter
- DBX2 p.Arg158His Uncertain significance Single submitter
- DBX2 p.Arg267Gln Uncertain significance Single submitter
- DBX2 p.Arg292Lys Uncertain significance Single submitter
- DBX2 p.Asn33Ser Uncertain significance Single submitter
- DBX2 p.Asp113Glu Uncertain significance Single submitter
- DBX2 p.Asp124Asn Uncertain significance Single submitter
- DBX2 p.Gln130Arg Uncertain significance Single submitter
- DBX2 p.Gln256Lys Uncertain significance Single submitter
- DBX2 p.Gln72His Uncertain significance Single submitter
- DBX2 p.Gly100Arg Uncertain significance Single submitter
- DBX2 p.Gly100Glu Uncertain significance Single submitter
- DBX2 p.Gly153Ser Uncertain significance Single submitter
- DBX2 p.Gly271Asp Uncertain significance Single submitter
- DBX2 p.Gly70Ser Uncertain significance Single submitter
- DBX2 p.His60Gln Uncertain significance Single submitter
- DBX2 p.His60Pro Uncertain significance Single submitter
- DBX2 p.Ile187Val Uncertain significance Single submitter
- DBX2 p.Ile221Val Uncertain significance Single submitter
- DBX2 p.Ile279Val Uncertain significance Single submitter
- DBX2 p.Ile40Asn Uncertain significance Single submitter
- DBX2 p.Leu22Phe Uncertain significance Single submitter
- DBX2 p.Leu265Phe Uncertain significance Single submitter
- DBX2 p.Leu34Pro Uncertain significance Single submitter
- DBX2 p.Lys213Glu Uncertain significance Single submitter
- DBX2 p.Phe147Leu Uncertain significance Single submitter
- DBX2 p.Phe31Ile Uncertain significance Single submitter
- DBX2 p.Pro131Leu Uncertain significance Single submitter
- DBX2 p.Pro145Leu Uncertain significance Single submitter
- DBX2 p.Pro159Leu Uncertain significance Single submitter
- DBX2 p.Pro159Ser Uncertain significance Single submitter
- DBX2 p.Pro264His Uncertain significance Single submitter
- DBX2 p.Pro264Thr Uncertain significance Single submitter
- DBX2 p.Pro273Ala Uncertain significance Single submitter
- DBX2 p.Pro59Ser Uncertain significance Single submitter
- DBX2 p.Pro62Ala Uncertain significance Single submitter
- DBX2 p.Pro75Leu Uncertain significance Single submitter
- DBX2 p.Pro94Ala Uncertain significance Single submitter
- DBX2 p.Pro98Ala Uncertain significance Single submitter
- DBX2 p.Ser143Arg Uncertain significance Single submitter
- DBX2 p.Ser212Gly Uncertain significance Single submitter
- DBX2 p.Ser306Thr Uncertain significance Single submitter
- DBX2 p.Thr144Asn Uncertain significance Single submitter
- DBX2 p.Trp14Ser Uncertain significance Single submitter
- DBX2 p.Val16Gly Uncertain significance Single submitter
- DBX2 p.Val17Leu Uncertain significance Single submitter
- DBX2 p.Val258Ile Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- DBX2 p.Ala28Thr Uncertain significance Single submitter
- DBX2 p.Arg184Trp Uncertain significance Single submitter
- DBX2 p.Asp196Gly Uncertain significance Single submitter
- DBX2 p.Gly11Asp Uncertain significance Single submitter
- DBX2 p.Pro26Leu Uncertain significance Single submitter
- DBX2 p.Pro57Ser Uncertain significance Single submitter
- DBX2 p.Pro82Thr Uncertain significance Single submitter
- DBX2 p.Ser20Cys Uncertain significance Single submitter
- DBX2 p.Ser274Phe Uncertain significance Single submitter
All DBX2 variants
Benign 1
- p.Arg267= Multiple submitters
Likely benign 3
- p.Ala58Pro Single submitter
- p.Asp61Gly Single submitter
- p.Val339Ile Single submitter
Uncertain significance 63
- p.Ala104Val Single submitter ⚠
- p.Ala10Gly Single submitter ⚠
- p.Ala12Gly Single submitter ⚠
- p.Ala150Thr Single submitter ⚠
- p.Ala21Pro Single submitter ⚠
- p.Ala28Thr Single submitter ⚠
- p.Ala309Thr Single submitter ⚠
- p.Ala8Val Single submitter ⚠
- p.Arg158Cys Single submitter ⚠
- p.Arg158His Single submitter ⚠
- p.Arg184Trp Single submitter ⚠
- p.Arg267Gln Single submitter ⚠
- p.Arg292Lys Single submitter ⚠
- p.Asn33Ser Single submitter ⚠
- p.Asp113Glu Single submitter ⚠
- p.Asp124Asn Single submitter ⚠
- p.Asp196Gly Single submitter ⚠
- p.Gln130Arg Single submitter ⚠
- p.Gln256Lys Single submitter ⚠
- p.Gln72His Single submitter ⚠
- p.Gly100Arg Single submitter ⚠
- p.Gly100Glu Single submitter ⚠
- p.Gly11Asp Single submitter ⚠
- p.Gly153Ser Single submitter ⚠
- p.Gly271Asp Single submitter ⚠
- p.Gly70Ser Single submitter ⚠
- p.His60Gln Single submitter ⚠
- p.His60Pro Single submitter ⚠
- p.Ile187Val Single submitter ⚠
- p.Ile221Val Single submitter ⚠
- p.Ile279Val Single submitter ⚠
- p.Ile40Asn Single submitter ⚠
- p.Leu22Phe Single submitter ⚠
- p.Leu265Phe Single submitter ⚠
- p.Leu34Pro Single submitter ⚠
- p.Lys213Glu Single submitter ⚠
- p.Phe147Leu Single submitter ⚠
- p.Phe31Ile Single submitter ⚠
- p.Pro131Leu Single submitter ⚠
- p.Pro145Leu Single submitter ⚠
- p.Pro159Leu Single submitter ⚠
- p.Pro159Ser Single submitter ⚠
- p.Pro264His Single submitter ⚠
- p.Pro264Thr Single submitter ⚠
- p.Pro26Leu Single submitter ⚠
- p.Pro273Ala Single submitter ⚠
- p.Pro57Ser Single submitter ⚠
- p.Pro59Ser Single submitter ⚠
- p.Pro62Ala Single submitter ⚠
- p.Pro75Leu Single submitter ⚠
- p.Pro82Thr Single submitter ⚠
- p.Pro94Ala Single submitter ⚠
- p.Pro98Ala Single submitter ⚠
- p.Ser143Arg Single submitter ⚠
- p.Ser20Cys Single submitter ⚠
- p.Ser212Gly Single submitter ⚠
- p.Ser274Phe Single submitter ⚠
- p.Ser306Thr Single submitter ⚠
- p.Thr144Asn Single submitter ⚠
- p.Trp14Ser Single submitter ⚠
- p.Val16Gly Single submitter ⚠
- p.Val17Leu Single submitter ⚠
- p.Val258Ile Single submitter ⚠