DCAF12L2 — 59 ClinVar variants

All ClinVar germline DCAF12L2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 57 flagged for review →

2 Conflicting · 1 Likely benign · 56 Uncertain significance

Full DCAF12L2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 57

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

DCAF12L2 p.Ser271Gly Conflicting Single submitter

Predictors lean, ClinVar uncertain 51

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 5

The independent predictors disagree with each other — read with care.

All DCAF12L2 variants

Conflicting classifications of pathogenicity 2

p.Phe270Cys Single submitter
p.Ser271Gly Single submitter ⚠

Likely benign 1

p.Met424Ile Single submitter

Uncertain significance 56

p.Ala108Ser Single submitter ⚠
p.Ala146Thr Single submitter ⚠
p.Ala243Ser Single submitter ⚠
p.Ala256Thr Single submitter ⚠
p.Ala279Ser Single submitter ⚠
p.Ala31Ser Single submitter ⚠
p.Arg132His Single submitter ⚠
p.Arg246Cys Single submitter ⚠
p.Arg63Pro Single submitter ⚠
p.Arg82Gly Single submitter ⚠
p.Asn412His Single submitter ⚠
p.Asn429Ser Single submitter ⚠
p.Asp183Glu Single submitter ⚠
p.Asp189Asn Single submitter ⚠
p.Asp223Glu Single submitter ⚠
p.Asp333Asn Single submitter ⚠
p.Gln126Glu Single submitter ⚠
p.Gln178Arg Single submitter ⚠
p.Gln380Arg Single submitter ⚠
p.Gln413Lys Single submitter ⚠
p.Glu17Lys Single submitter ⚠
p.Glu236Val Single submitter ⚠
p.Gly167Ser Single submitter ⚠
p.Gly19Arg Single submitter ⚠
p.Gly211Ser Single submitter ⚠
p.Gly21Glu Single submitter ⚠
p.Gly349Ser Single submitter ⚠
p.Gly35Glu Single submitter ⚠
p.Gly370Asp Single submitter ⚠
p.Gly64Val Single submitter ⚠
p.Gly67Arg Single submitter ⚠
p.Gly73Asp Single submitter ⚠
p.Gly77Arg Single submitter ⚠
p.His234Tyr Single submitter ⚠
p.His328Gln Single submitter ⚠
p.Leu135Arg Single submitter ⚠
p.Leu298Val Single submitter ⚠
p.Leu461Val Single submitter ⚠
p.Lys264Asn Single submitter ⚠
p.Met222Ile Single submitter ⚠
p.Pro260Arg Single submitter ⚠
p.Pro395Leu Single submitter ⚠
p.Pro84His Single submitter ⚠
p.Ser210Arg Single submitter ⚠
p.Ser210Ile Single submitter ⚠
p.Ser210Thr Single submitter ⚠
p.Ser327Cys Single submitter ⚠
p.Ser330Thr Single submitter ⚠
p.Thr131Met Single submitter ⚠
p.Thr47Pro Single submitter ⚠
p.Tyr177Cys Single submitter ⚠
p.Tyr177His Single submitter ⚠
p.Val123Ala Single submitter ⚠
p.Val310Met Single submitter ⚠
p.Val323Gly Single submitter ⚠
p.Val52Ala Single submitter ⚠