DCAF13 — 78 ClinVar variants
All ClinVar germline DCAF13 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 63 flagged for review →
2 Benign · 3 Likely benign · 73 Uncertain significance
Full DCAF13 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 63
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 27
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DCAF13 p.His327Arg Uncertain significance Multiple submitters
- DCAF13 p.Phe381Cys Uncertain significance Multiple submitters
- DCAF13 p.Arg118His Uncertain significance Single submitter
- DCAF13 p.Arg23Lys Uncertain significance Single submitter
- DCAF13 p.Arg269Cys Uncertain significance Single submitter
- DCAF13 p.Arg307Gln Uncertain significance Single submitter
- DCAF13 p.Asn12Ser Uncertain significance Single submitter
- DCAF13 p.Asn258Ser Uncertain significance Single submitter
- DCAF13 p.Asp179His Uncertain significance Single submitter
- DCAF13 p.Asp345Asn Uncertain significance Single submitter
- DCAF13 p.Glu146Lys Uncertain significance Single submitter
- DCAF13 p.His108Arg Uncertain significance Single submitter
- DCAF13 p.His281Asp Uncertain significance Single submitter
- DCAF13 p.His281Tyr Uncertain significance Single submitter
- DCAF13 p.Ile329Phe Uncertain significance Single submitter
- DCAF13 p.Ile390Thr Uncertain significance Single submitter
- DCAF13 p.Leu83Arg Uncertain significance Single submitter
- DCAF13 p.Lys2Arg Uncertain significance Single submitter
- DCAF13 p.Lys378Asn Uncertain significance Single submitter
- DCAF13 p.Met410Thr Uncertain significance Single submitter
- DCAF13 p.Pro248Leu Uncertain significance Single submitter
- DCAF13 p.Ser429Thr Uncertain significance Single submitter
- DCAF13 p.Thr255Ile Uncertain significance Single submitter
- DCAF13 p.Trp136Gly Uncertain significance Single submitter
- DCAF13 p.Val222Ile Uncertain significance Single submitter
- DCAF13 p.Val319Ile Uncertain significance Single submitter
- DCAF13 p.Val3Ala Uncertain significance Single submitter
Predictors split 36
The independent predictors disagree with each other — read with care.
- DCAF13 p.Arg103His Uncertain significance Single submitter
- DCAF13 p.Arg118Cys Uncertain significance Single submitter
- DCAF13 p.Arg389His Uncertain significance Single submitter
- DCAF13 p.Arg39Gln Uncertain significance Single submitter
- DCAF13 p.Arg408His Uncertain significance Single submitter
- DCAF13 p.Arg414His Uncertain significance Single submitter
- DCAF13 p.Arg416Gln Uncertain significance Single submitter
- DCAF13 p.Arg66Cys Uncertain significance Single submitter
- DCAF13 p.Asp372His Uncertain significance Single submitter
- DCAF13 p.Gln177Glu Uncertain significance Single submitter
- DCAF13 p.Glu147Gly Uncertain significance Single submitter
- DCAF13 p.Glu183Ala Uncertain significance Single submitter
- DCAF13 p.Glu183Gly Uncertain significance Single submitter
- DCAF13 p.Glu183Val Uncertain significance Single submitter
- DCAF13 p.Glu412Lys Uncertain significance Single submitter
- DCAF13 p.Gly110Ala Uncertain significance Single submitter
- DCAF13 p.His327Tyr Uncertain significance Single submitter
- DCAF13 p.Ile400Met Uncertain significance Single submitter
- DCAF13 p.Ile409Thr Uncertain significance Single submitter
- DCAF13 p.Leu150Ser Uncertain significance Single submitter
- DCAF13 p.Leu83Phe Uncertain significance Single submitter
- DCAF13 p.Lys4Thr Uncertain significance Single submitter
- DCAF13 p.Met239Val Uncertain significance Single submitter
- DCAF13 p.Met341Thr Uncertain significance Single submitter
- DCAF13 p.Pro141Ser Uncertain significance Single submitter
- DCAF13 p.Pro231Ser Uncertain significance Single submitter
- DCAF13 p.Pro25Ser Uncertain significance Single submitter
- DCAF13 p.Pro30Leu Uncertain significance Single submitter
- DCAF13 p.Ser191Ala Uncertain significance Single submitter
- DCAF13 p.Ser301Gly Uncertain significance Single submitter
- DCAF13 p.Ser425Cys Uncertain significance Single submitter
- DCAF13 p.Ser429Tyr Uncertain significance Single submitter
- DCAF13 p.Thr255Ala Uncertain significance Single submitter
- DCAF13 p.Tyr401His Uncertain significance Single submitter
- DCAF13 p.Val235Phe Uncertain significance Single submitter
- DCAF13 p.Val433Ala Uncertain significance Single submitter
All DCAF13 variants
Benign 2
- p.Ala109Gly Multiple submitters
- p.Ala70= Multiple submitters
Likely benign 3
- c.624+15del Single submitter
- c.-12A>G Single submitter
- c.-34C>G Single submitter
Uncertain significance 73
- p.His327Arg Multiple submitters ⚠
- p.Phe381Cys Multiple submitters ⚠
- c.-20C>T Single submitter
- c.-30T>C Single submitter
- c.-33A>G Single submitter
- c.-38C>A Single submitter
- c.-8C>G Single submitter
- p.Ala53Thr Single submitter
- p.Arg103His Single submitter ⚠
- p.Arg112Gly Single submitter
- p.Arg118Cys Single submitter ⚠
- p.Arg118His Single submitter ⚠
- p.Arg23Lys Single submitter ⚠
- p.Arg269Cys Single submitter ⚠
- p.Arg307Gln Single submitter ⚠
- p.Arg389His Single submitter ⚠
- p.Arg39Gln Single submitter ⚠
- p.Arg408His Single submitter ⚠
- p.Arg414His Single submitter ⚠
- p.Arg416Gln Single submitter ⚠
- p.Arg66Cys Single submitter ⚠
- p.Asn12Ser Single submitter ⚠
- p.Asn258Ser Single submitter ⚠
- p.Asn93Ser Single submitter
- p.Asp179His Single submitter ⚠
- p.Asp345Asn Single submitter ⚠
- p.Asp372His Single submitter ⚠
- p.Gln177Glu Single submitter ⚠
- p.Glu146Lys Single submitter ⚠
- p.Glu147Gly Single submitter ⚠
- p.Glu183Ala Single submitter ⚠
- p.Glu183Gly Single submitter ⚠
- p.Glu183Val Single submitter ⚠
- p.Glu412Lys Single submitter ⚠
- p.Glu88Gln Single submitter
- p.Gly110Ala Single submitter ⚠
- p.His108Arg Single submitter ⚠
- p.His281Asp Single submitter ⚠
- p.His281Tyr Single submitter ⚠
- p.His327Tyr Single submitter ⚠
- p.Ile329Phe Single submitter ⚠
- p.Ile390Thr Single submitter ⚠
- p.Ile400Met Single submitter ⚠
- p.Ile409Thr Single submitter ⚠
- p.Leu150Ser Single submitter ⚠
- p.Leu83Arg Single submitter ⚠
- p.Leu83Phe Single submitter ⚠
- p.Lys2Arg Single submitter ⚠
- p.Lys378Asn Single submitter ⚠
- p.Lys4Thr Single submitter ⚠
- p.Met239Val Single submitter ⚠
- p.Met341Thr Single submitter ⚠
- p.Met410Thr Single submitter ⚠
- p.Pro141Ser Single submitter ⚠
- p.Pro231Ser Single submitter ⚠
- p.Pro248Leu Single submitter ⚠
- p.Pro25Ser Single submitter ⚠
- p.Pro30Leu Single submitter ⚠
- p.Pro65Ser Single submitter
- p.Ser191Ala Single submitter ⚠
- p.Ser301Gly Single submitter ⚠
- p.Ser425Cys Single submitter ⚠
- p.Ser429Thr Single submitter ⚠
- p.Ser429Tyr Single submitter ⚠
- p.Thr255Ala Single submitter ⚠
- p.Thr255Ile Single submitter ⚠
- p.Trp136Gly Single submitter ⚠
- p.Tyr401His Single submitter ⚠
- p.Val222Ile Single submitter ⚠
- p.Val235Phe Single submitter ⚠
- p.Val319Ile Single submitter ⚠
- p.Val3Ala Single submitter ⚠
- p.Val433Ala Single submitter ⚠