DCAF15 — 75 ClinVar variants
All ClinVar germline DCAF15 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 68 flagged for review →
2 Benign · 3 Likely benign · 70 Uncertain significance
Full DCAF15 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 68
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 56
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DCAF15 p.Ala149Thr Uncertain significance Single submitter
- DCAF15 p.Ala149Val Uncertain significance Single submitter
- DCAF15 p.Ala162Gly Uncertain significance Single submitter
- DCAF15 p.Ala23Gly Uncertain significance Single submitter
- DCAF15 p.Ala303Val Uncertain significance Single submitter
- DCAF15 p.Ala305Gly Uncertain significance Single submitter
- DCAF15 p.Ala316Thr Uncertain significance Single submitter
- DCAF15 p.Ala357Val Uncertain significance Single submitter
- DCAF15 p.Ala462Asp Uncertain significance Single submitter
- DCAF15 p.Arg160His Uncertain significance Single submitter
- DCAF15 p.Arg213Gln Uncertain significance Single submitter
- DCAF15 p.Arg306Cys Uncertain significance Single submitter
- DCAF15 p.Arg306Pro Uncertain significance Single submitter
- DCAF15 p.Arg330Gln Uncertain significance Single submitter
- DCAF15 p.Arg354His Uncertain significance Single submitter
- DCAF15 p.Arg356Cys Uncertain significance Single submitter
- DCAF15 p.Arg371Trp Uncertain significance Single submitter
- DCAF15 p.Arg423Cys Uncertain significance Single submitter
- DCAF15 p.Arg423His Uncertain significance Single submitter
- DCAF15 p.Arg425His Uncertain significance Single submitter
- DCAF15 p.Arg428Gln Uncertain significance Single submitter
- DCAF15 p.Arg431Gln Uncertain significance Single submitter
- DCAF15 p.Arg552Cys Uncertain significance Single submitter
- DCAF15 p.Asn10Ser Uncertain significance Single submitter
- DCAF15 p.Asn426Ser Uncertain significance Single submitter
- DCAF15 p.Gln467Glu Uncertain significance Single submitter
- DCAF15 p.Glu383Asp Uncertain significance Single submitter
- DCAF15 p.Glu400Asp Uncertain significance Single submitter
- DCAF15 p.Glu405Gly Uncertain significance Single submitter
- DCAF15 p.Glu432Lys Uncertain significance Single submitter
- DCAF15 p.Glu529Lys Uncertain significance Single submitter
- DCAF15 p.Gly21Ala Uncertain significance Single submitter
- DCAF15 p.Gly366Glu Uncertain significance Single submitter
- DCAF15 p.Gly399Arg Uncertain significance Single submitter
- DCAF15 p.Lys321Arg Uncertain significance Single submitter
- DCAF15 p.Lys561Arg Uncertain significance Single submitter
- DCAF15 p.Met170Leu Uncertain significance Single submitter
- DCAF15 p.Met172Val Uncertain significance Single submitter
- DCAF15 p.Pro207Leu Uncertain significance Single submitter
- DCAF15 p.Pro20Leu Uncertain significance Single submitter
- DCAF15 p.Pro227Thr Uncertain significance Single submitter
- DCAF15 p.Pro289Leu Uncertain significance Single submitter
- DCAF15 p.Pro313His Uncertain significance Single submitter
- DCAF15 p.Pro502Leu Uncertain significance Single submitter
- DCAF15 p.Ser260Trp Uncertain significance Single submitter
- DCAF15 p.Ser282Arg Uncertain significance Single submitter
- DCAF15 p.Ser308Phe Uncertain significance Single submitter
- DCAF15 p.Ser7Pro Uncertain significance Single submitter
- DCAF15 p.Ser95Cys Uncertain significance Single submitter
- DCAF15 p.Ser97Thr Uncertain significance Single submitter
- DCAF15 p.Thr596Met Uncertain significance Single submitter
- DCAF15 p.Tyr75Cys Uncertain significance Single submitter
- DCAF15 p.Val154Ile Uncertain significance Single submitter
- DCAF15 p.Val488Ile Uncertain significance Single submitter
- DCAF15 p.Val572Ile Uncertain significance Single submitter
- DCAF15 p.Val90Ile Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- DCAF15 p.Ala2Val Uncertain significance Single submitter
- DCAF15 p.Arg178His Uncertain significance Single submitter
- DCAF15 p.Gly12Arg Uncertain significance Single submitter
- DCAF15 p.Gly14Arg Uncertain significance Single submitter
- DCAF15 p.Ile492Leu Uncertain significance Single submitter
- DCAF15 p.Leu415Pro Uncertain significance Single submitter
- DCAF15 p.Leu53Phe Uncertain significance Single submitter
- DCAF15 p.Met172Ile Uncertain significance Single submitter
- DCAF15 p.Ser7Trp Uncertain significance Single submitter
- DCAF15 p.Trp562Arg Uncertain significance Single submitter
- DCAF15 p.Val252Met Uncertain significance Single submitter
- DCAF15 p.Val533Leu Uncertain significance Single submitter
All DCAF15 variants
Benign 2
- p.Ile153= Multiple submitters
- c.1440+14_1440+33dup Single submitter
Likely benign 3
- c.1440+33_1440+34insGGGCAGGGTGGGCCCAGGGCGGGCAGGGTGGGCCCAGGGC Single submitter
- p.Ala345Pro Single submitter
- p.Pro339Ser Single submitter
Uncertain significance 70
- p.Ala149Thr Single submitter ⚠
- p.Ala149Val Single submitter ⚠
- p.Ala162Gly Single submitter ⚠
- p.Ala23Gly Single submitter ⚠
- p.Ala2Val Single submitter ⚠
- p.Ala303Val Single submitter ⚠
- p.Ala305Gly Single submitter ⚠
- p.Ala316Thr Single submitter ⚠
- p.Ala357Val Single submitter ⚠
- p.Ala462Asp Single submitter ⚠
- p.Arg160His Single submitter ⚠
- p.Arg178His Single submitter ⚠
- p.Arg213Gln Single submitter ⚠
- p.Arg306Cys Single submitter ⚠
- p.Arg306Pro Single submitter ⚠
- p.Arg330Gln Single submitter ⚠
- p.Arg354His Single submitter ⚠
- p.Arg356Cys Single submitter ⚠
- p.Arg371Trp Single submitter ⚠
- p.Arg423Cys Single submitter ⚠
- p.Arg423His Single submitter ⚠
- p.Arg425His Single submitter ⚠
- p.Arg428Gln Single submitter ⚠
- p.Arg431Gln Single submitter ⚠
- p.Arg459Cys Single submitter
- p.Arg552Cys Single submitter ⚠
- p.Asn10Ser Single submitter ⚠
- p.Asn426Ser Single submitter ⚠
- p.Asp535His Single submitter
- p.Gln467Glu Single submitter ⚠
- p.Glu383Asp Single submitter ⚠
- p.Glu400Asp Single submitter ⚠
- p.Glu405Gly Single submitter ⚠
- p.Glu432Lys Single submitter ⚠
- p.Glu529Lys Single submitter ⚠
- p.Gly12Arg Single submitter ⚠
- p.Gly14Arg Single submitter ⚠
- p.Gly21Ala Single submitter ⚠
- p.Gly366Glu Single submitter ⚠
- p.Gly399Arg Single submitter ⚠
- p.Ile492Leu Single submitter ⚠
- p.Leu415Pro Single submitter ⚠
- p.Leu53Phe Single submitter ⚠
- p.Lys321Arg Single submitter ⚠
- p.Lys561Arg Single submitter ⚠
- p.Met170Leu Single submitter ⚠
- p.Met172Ile Single submitter ⚠
- p.Met172Val Single submitter ⚠
- p.Pro207Leu Single submitter ⚠
- p.Pro20Leu Single submitter ⚠
- p.Pro227Thr Single submitter ⚠
- p.Pro289Leu Single submitter ⚠
- p.Pro313His Single submitter ⚠
- p.Pro502Leu Single submitter ⚠
- p.Ser260Trp Single submitter ⚠
- p.Ser282Arg Single submitter ⚠
- p.Ser308Phe Single submitter ⚠
- p.Ser7Pro Single submitter ⚠
- p.Ser7Trp Single submitter ⚠
- p.Ser95Cys Single submitter ⚠
- p.Ser97Thr Single submitter ⚠
- p.Thr596Met Single submitter ⚠
- p.Trp562Arg Single submitter ⚠
- p.Tyr75Cys Single submitter ⚠
- p.Val154Ile Single submitter ⚠
- p.Val252Met Single submitter ⚠
- p.Val488Ile Single submitter ⚠
- p.Val533Leu Single submitter ⚠
- p.Val572Ile Single submitter ⚠
- p.Val90Ile Single submitter ⚠