DCAF16 — 33 ClinVar variants
All ClinVar germline DCAF16 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 33 flagged for review →
33 Uncertain significance
Full DCAF16 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 33
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 24
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DCAF16 p.Ala144Thr Uncertain significance Single submitter
- DCAF16 p.Ala78Thr Uncertain significance Single submitter
- DCAF16 p.Arg191His Uncertain significance Single submitter
- DCAF16 p.Arg91Gln Uncertain significance Single submitter
- DCAF16 p.Asn171Ser Uncertain significance Single submitter
- DCAF16 p.Asp137Glu Uncertain significance Single submitter
- DCAF16 p.Asp9Val Uncertain significance Single submitter
- DCAF16 p.Glu27Asp Uncertain significance Single submitter
- DCAF16 p.Glu50Lys Uncertain significance Single submitter
- DCAF16 p.Gly2Ser Uncertain significance Single submitter
- DCAF16 p.His138Arg Uncertain significance Single submitter
- DCAF16 p.His99Arg Uncertain significance Single submitter
- DCAF16 p.Ile93Thr Uncertain significance Single submitter
- DCAF16 p.Ile93Val Uncertain significance Single submitter
- DCAF16 p.Leu128Pro Uncertain significance Single submitter
- DCAF16 p.Lys150Gln Uncertain significance Single submitter
- DCAF16 p.Pro194Leu Uncertain significance Single submitter
- DCAF16 p.Ser47Leu Uncertain significance Single submitter
- DCAF16 p.Thr160Pro Uncertain significance Single submitter
- DCAF16 p.Thr197Ala Uncertain significance Single submitter
- DCAF16 p.Thr198Ile Uncertain significance Single submitter
- DCAF16 p.Trp33Arg Uncertain significance Single submitter
- DCAF16 p.Tyr76Cys Uncertain significance Single submitter
- DCAF16 p.Val56Ile Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- DCAF16 p.Arg96Ser Uncertain significance Single submitter
- DCAF16 p.Glu31Lys Uncertain significance Single submitter
- DCAF16 p.Glu38Lys Uncertain significance Single submitter
- DCAF16 p.His77Gln Uncertain significance Single submitter
- DCAF16 p.Pro105Ser Uncertain significance Single submitter
- DCAF16 p.Ser16Arg Uncertain significance Single submitter
- DCAF16 p.Trp113Arg Uncertain significance Single submitter
- DCAF16 p.Tyr199Ser Uncertain significance Single submitter
- DCAF16 p.Val121Asp Uncertain significance Single submitter
All DCAF16 variants
Uncertain significance 33
- p.Ala144Thr Single submitter ⚠
- p.Ala78Thr Single submitter ⚠
- p.Arg191His Single submitter ⚠
- p.Arg91Gln Single submitter ⚠
- p.Arg96Ser Single submitter ⚠
- p.Asn171Ser Single submitter ⚠
- p.Asp137Glu Single submitter ⚠
- p.Asp9Val Single submitter ⚠
- p.Glu27Asp Single submitter ⚠
- p.Glu31Lys Single submitter ⚠
- p.Glu38Lys Single submitter ⚠
- p.Glu50Lys Single submitter ⚠
- p.Gly2Ser Single submitter ⚠
- p.His138Arg Single submitter ⚠
- p.His77Gln Single submitter ⚠
- p.His99Arg Single submitter ⚠
- p.Ile93Thr Single submitter ⚠
- p.Ile93Val Single submitter ⚠
- p.Leu128Pro Single submitter ⚠
- p.Lys150Gln Single submitter ⚠
- p.Pro105Ser Single submitter ⚠
- p.Pro194Leu Single submitter ⚠
- p.Ser16Arg Single submitter ⚠
- p.Ser47Leu Single submitter ⚠
- p.Thr160Pro Single submitter ⚠
- p.Thr197Ala Single submitter ⚠
- p.Thr198Ile Single submitter ⚠
- p.Trp113Arg Single submitter ⚠
- p.Trp33Arg Single submitter ⚠
- p.Tyr199Ser Single submitter ⚠
- p.Tyr76Cys Single submitter ⚠
- p.Val121Asp Single submitter ⚠
- p.Val56Ile Single submitter ⚠