DCAF4L1 — 31 ClinVar variants
All ClinVar germline DCAF4L1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 31 flagged for review →
31 Uncertain significance
Full DCAF4L1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 31
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 22
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DCAF4L1 p.Ala196Val Uncertain significance Single submitter
- DCAF4L1 p.Ala236Thr Uncertain significance Single submitter
- DCAF4L1 p.Ala301Val Uncertain significance Single submitter
- DCAF4L1 p.Ala379Pro Uncertain significance Single submitter
- DCAF4L1 p.Ala3Thr Uncertain significance Single submitter
- DCAF4L1 p.Ala3Val Uncertain significance Single submitter
- DCAF4L1 p.Ala79Thr Uncertain significance Single submitter
- DCAF4L1 p.Gln231Arg Uncertain significance Single submitter
- DCAF4L1 p.Glu12Asp Uncertain significance Single submitter
- DCAF4L1 p.Glu282Asp Uncertain significance Single submitter
- DCAF4L1 p.Glu95Lys Uncertain significance Single submitter
- DCAF4L1 p.His321Arg Uncertain significance Single submitter
- DCAF4L1 p.Ile278Val Uncertain significance Single submitter
- DCAF4L1 p.Lys260Asn Uncertain significance Single submitter
- DCAF4L1 p.Met28Val Uncertain significance Single submitter
- DCAF4L1 p.Ser103Asn Uncertain significance Single submitter
- DCAF4L1 p.Ser179Cys Uncertain significance Single submitter
- DCAF4L1 p.Thr235Ala Uncertain significance Single submitter
- DCAF4L1 p.Tyr317Cys Uncertain significance Single submitter
- DCAF4L1 p.Tyr356Cys Uncertain significance Single submitter
- DCAF4L1 p.Val116Leu Uncertain significance Single submitter
- DCAF4L1 p.Val142Leu Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- DCAF4L1 p.Ala346Val Uncertain significance Single submitter
- DCAF4L1 p.Arg254Ser Uncertain significance Single submitter
- DCAF4L1 p.Arg266Cys Uncertain significance Single submitter
- DCAF4L1 p.Arg387Trp Uncertain significance Single submitter
- DCAF4L1 p.Arg5Gly Uncertain significance Single submitter
- DCAF4L1 p.Asp151Gly Uncertain significance Single submitter
- DCAF4L1 p.Pro355Arg Uncertain significance Single submitter
- DCAF4L1 p.Ser225Gly Uncertain significance Single submitter
- DCAF4L1 p.Val322Leu Uncertain significance Single submitter
All DCAF4L1 variants
Uncertain significance 31
- p.Ala196Val Single submitter ⚠
- p.Ala236Thr Single submitter ⚠
- p.Ala301Val Single submitter ⚠
- p.Ala346Val Single submitter ⚠
- p.Ala379Pro Single submitter ⚠
- p.Ala3Thr Single submitter ⚠
- p.Ala3Val Single submitter ⚠
- p.Ala79Thr Single submitter ⚠
- p.Arg254Ser Single submitter ⚠
- p.Arg266Cys Single submitter ⚠
- p.Arg387Trp Single submitter ⚠
- p.Arg5Gly Single submitter ⚠
- p.Asp151Gly Single submitter ⚠
- p.Gln231Arg Single submitter ⚠
- p.Glu12Asp Single submitter ⚠
- p.Glu282Asp Single submitter ⚠
- p.Glu95Lys Single submitter ⚠
- p.His321Arg Single submitter ⚠
- p.Ile278Val Single submitter ⚠
- p.Lys260Asn Single submitter ⚠
- p.Met28Val Single submitter ⚠
- p.Pro355Arg Single submitter ⚠
- p.Ser103Asn Single submitter ⚠
- p.Ser179Cys Single submitter ⚠
- p.Ser225Gly Single submitter ⚠
- p.Thr235Ala Single submitter ⚠
- p.Tyr317Cys Single submitter ⚠
- p.Tyr356Cys Single submitter ⚠
- p.Val116Leu Single submitter ⚠
- p.Val142Leu Single submitter ⚠
- p.Val322Leu Single submitter ⚠