DCAF4L2 — 73 ClinVar variants
All ClinVar germline DCAF4L2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 55 flagged for review →
3 Benign · 12 Likely benign · 58 Uncertain significance
Full DCAF4L2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 55
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 48
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DCAF4L2 p.Ala12Val Uncertain significance Single submitter
- DCAF4L2 p.Ala185Ser Uncertain significance Single submitter
- DCAF4L2 p.Ala25Val Uncertain significance Single submitter
- DCAF4L2 p.Ala367Thr Uncertain significance Single submitter
- DCAF4L2 p.Arg30Gln Uncertain significance Single submitter
- DCAF4L2 p.Arg371Cys Uncertain significance Single submitter
- DCAF4L2 p.Arg50His Uncertain significance Single submitter
- DCAF4L2 p.Arg76Leu Uncertain significance Single submitter
- DCAF4L2 p.Asn124Ser Uncertain significance Single submitter
- DCAF4L2 p.Asn41Ser Uncertain significance Single submitter
- DCAF4L2 p.Asp13Glu Uncertain significance Single submitter
- DCAF4L2 p.Asp184His Uncertain significance Single submitter
- DCAF4L2 p.Cys131Trp Uncertain significance Single submitter
- DCAF4L2 p.Cys145Arg Uncertain significance Single submitter
- DCAF4L2 p.Cys43Tyr Uncertain significance Single submitter
- DCAF4L2 p.Gln218Arg Uncertain significance Single submitter
- DCAF4L2 p.Gln60His Uncertain significance Single submitter
- DCAF4L2 p.Gly203Asp Uncertain significance Single submitter
- DCAF4L2 p.Gly256Glu Uncertain significance Single submitter
- DCAF4L2 p.His117Asp Uncertain significance Single submitter
- DCAF4L2 p.His137Gln Uncertain significance Single submitter
- DCAF4L2 p.Ile234Val Uncertain significance Single submitter
- DCAF4L2 p.Ile248Asn Uncertain significance Single submitter
- DCAF4L2 p.Ile363Val Uncertain significance Single submitter
- DCAF4L2 p.Leu112Pro Uncertain significance Single submitter
- DCAF4L2 p.Leu138Met Uncertain significance Single submitter
- DCAF4L2 p.Leu192Arg Uncertain significance Single submitter
- DCAF4L2 p.Leu192Val Uncertain significance Single submitter
- DCAF4L2 p.Leu209Gln Uncertain significance Single submitter
- DCAF4L2 p.Leu279Val Uncertain significance Single submitter
- DCAF4L2 p.Leu299Phe Uncertain significance Single submitter
- DCAF4L2 p.Leu381Gln Uncertain significance Single submitter
- DCAF4L2 p.Leu78Val Uncertain significance Single submitter
- DCAF4L2 p.Lys17Gln Uncertain significance Single submitter
- DCAF4L2 p.Met130Ile Uncertain significance Single submitter
- DCAF4L2 p.Met235Lys Uncertain significance Single submitter
- DCAF4L2 p.Pro123Ser Uncertain significance Single submitter
- DCAF4L2 p.Pro160Thr Uncertain significance Single submitter
- DCAF4L2 p.Pro357Ala Uncertain significance Single submitter
- DCAF4L2 p.Pro364Thr Uncertain significance Single submitter
- DCAF4L2 p.Ser187Cys Uncertain significance Single submitter
- DCAF4L2 p.Ser220Leu Uncertain significance Single submitter
- DCAF4L2 p.Thr236Ala Uncertain significance Single submitter
- DCAF4L2 p.Thr291Ile Uncertain significance Single submitter
- DCAF4L2 p.Thr293Ala Uncertain significance Single submitter
- DCAF4L2 p.Tyr42Cys Uncertain significance Single submitter
- DCAF4L2 p.Val19Gly Uncertain significance Single submitter
- DCAF4L2 p.Val51Leu Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- DCAF4L2 p.Arg254His Uncertain significance Single submitter
- DCAF4L2 p.Glu326Gly Uncertain significance Single submitter
- DCAF4L2 p.Leu267Gln Uncertain significance Single submitter
- DCAF4L2 p.Phe180Leu Uncertain significance Single submitter
- DCAF4L2 p.Phe74Cys Uncertain significance Single submitter
- DCAF4L2 p.Thr215Met Uncertain significance Single submitter
- DCAF4L2 p.Trp186Cys Uncertain significance Single submitter
All DCAF4L2 variants
Benign 3
- p.Arg47= No assertion criteria DCAF4L2-related disorder
- p.Asn313Ser No assertion criteria DCAF4L2-related disorder
- p.Phe146= No assertion criteria DCAF4L2-related disorder
Likely benign 12
- p.Asn24Ser Single submitter
- p.Glu326del Single submitter
- p.Leu279Phe Single submitter
- p.Ser315Phe Single submitter
- p.Ser3Asn Single submitter
- p.Asn212= No assertion criteria DCAF4L2-related disorder
- p.Asn361= No assertion criteria DCAF4L2-related disorder
- p.Cys336= No assertion criteria DCAF4L2-related disorder
- p.Gly22= No assertion criteria DCAF4L2-related disorder
- p.Gly282= No assertion criteria DCAF4L2-related disorder
- p.Leu276= No assertion criteria DCAF4L2-related disorder
- p.Val312= No assertion criteria DCAF4L2-related disorder
Uncertain significance 58
- p.Ala12Val Single submitter ⚠
- p.Ala185Ser Single submitter ⚠
- p.Ala25Val Single submitter ⚠
- p.Ala367Thr Single submitter ⚠
- p.Arg254His Single submitter ⚠
- p.Arg30Gln Single submitter ⚠
- p.Arg371Cys Single submitter ⚠
- p.Arg50His Single submitter ⚠
- p.Arg76Leu Single submitter ⚠
- p.Asn124Ser Single submitter ⚠
- p.Asn41Ser Single submitter ⚠
- p.Asp13Glu Single submitter ⚠
- p.Asp184His Single submitter ⚠
- p.Cys131Trp Single submitter ⚠
- p.Cys145Arg Single submitter ⚠
- p.Cys43Tyr Single submitter ⚠
- p.Gln218Arg Single submitter ⚠
- p.Gln60His Single submitter ⚠
- p.Glu326Gly Single submitter ⚠
- p.Gly203Asp Single submitter ⚠
- p.Gly256Glu Single submitter ⚠
- p.His117Asp Single submitter ⚠
- p.His137Gln Single submitter ⚠
- p.His269Pro Single submitter
- p.Ile234Val Single submitter ⚠
- p.Ile248Asn Single submitter ⚠
- p.Ile363Val Single submitter ⚠
- p.Leu112Pro Single submitter ⚠
- p.Leu138Met Single submitter ⚠
- p.Leu192Arg Single submitter ⚠
- p.Leu192Val Single submitter ⚠
- p.Leu209Gln Single submitter ⚠
- p.Leu267Gln Single submitter ⚠
- p.Leu279Val Single submitter ⚠
- p.Leu299Phe Single submitter ⚠
- p.Leu381Gln Single submitter ⚠
- p.Leu78Val Single submitter ⚠
- p.Lys17Gln Single submitter ⚠
- p.Met130Ile Single submitter ⚠
- p.Met235Lys Single submitter ⚠
- p.Phe180Leu Single submitter ⚠
- p.Phe74Cys Single submitter ⚠
- p.Pro123Ser Single submitter ⚠
- p.Pro160Thr Single submitter ⚠
- p.Pro357Ala Single submitter ⚠
- p.Pro364Thr Single submitter ⚠
- p.Ser187Cys Single submitter ⚠
- p.Ser220Leu Single submitter ⚠
- p.Thr215Met Single submitter ⚠
- p.Thr236Ala Single submitter ⚠
- p.Thr291Ile Single submitter ⚠
- p.Thr293Ala Single submitter ⚠
- p.Trp186Cys Single submitter ⚠
- p.Tyr42Cys Single submitter ⚠
- p.Val127Ala Single submitter
- p.Val19Gly Single submitter ⚠
- p.Val366Ala Single submitter
- p.Val51Leu Single submitter ⚠