DCAF5 — 91 ClinVar variants
All ClinVar germline DCAF5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 82 flagged for review →
7 Likely benign · 84 Uncertain significance
Full DCAF5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 82
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 74
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DCAF5 p.Ala250Asp Uncertain significance Single submitter
- DCAF5 p.Ala526Thr Uncertain significance Single submitter
- DCAF5 p.Ala647Pro Uncertain significance Single submitter
- DCAF5 p.Ala800Pro Uncertain significance Single submitter
- DCAF5 p.Arg291Cys Uncertain significance Single submitter
- DCAF5 p.Arg375Gln Uncertain significance Single submitter
- DCAF5 p.Arg467His Uncertain significance Single submitter
- DCAF5 p.Arg487Gln Uncertain significance Single submitter
- DCAF5 p.Arg509His Uncertain significance Single submitter
- DCAF5 p.Arg512His Uncertain significance Single submitter
- DCAF5 p.Arg518Cys Uncertain significance Single submitter
- DCAF5 p.Arg551Gln Uncertain significance Single submitter
- DCAF5 p.Arg578Gly Uncertain significance Single submitter
- DCAF5 p.Arg595Gln Uncertain significance Single submitter
- DCAF5 p.Arg646Gln Uncertain significance Single submitter
- DCAF5 p.Arg658Gln Uncertain significance Single submitter
- DCAF5 p.Arg77Trp Uncertain significance Single submitter
- DCAF5 p.Arg788Gln Uncertain significance Single submitter
- DCAF5 p.Arg836Cys Uncertain significance Single submitter
- DCAF5 p.Arg836His Uncertain significance Single submitter
- DCAF5 p.Asn185Asp Uncertain significance Single submitter
- DCAF5 p.Asn846Asp Uncertain significance Single submitter
- DCAF5 p.Asn894Asp Uncertain significance Single submitter
- DCAF5 p.Asp164Glu Uncertain significance Single submitter
- DCAF5 p.Asp722Glu Uncertain significance Single submitter
- DCAF5 p.Asp868His Uncertain significance Single submitter
- DCAF5 p.Cys538Phe Uncertain significance Single submitter
- DCAF5 p.Gln643His Uncertain significance Single submitter
- DCAF5 p.Gln718Lys Uncertain significance Single submitter
- DCAF5 p.Glu826Lys Uncertain significance Single submitter
- DCAF5 p.Glu887Ala Uncertain significance Single submitter
- DCAF5 p.Glu932Ala Uncertain significance Single submitter
- DCAF5 p.Gly298Val Uncertain significance Single submitter
- DCAF5 p.Gly317Ser Uncertain significance Single submitter
- DCAF5 p.Gly40Ser Uncertain significance Single submitter
- DCAF5 p.Gly687Arg Uncertain significance Single submitter
- DCAF5 p.Gly6Ala Uncertain significance Single submitter
- DCAF5 p.Gly746Cys Uncertain significance Single submitter
- DCAF5 p.Gly766Asp Uncertain significance Single submitter
- DCAF5 p.Gly769Ser Uncertain significance Single submitter
- DCAF5 p.Gly848Arg Uncertain significance Single submitter
- DCAF5 p.Gly915Asp Uncertain significance Single submitter
- DCAF5 p.His24Arg Uncertain significance Single submitter
- DCAF5 p.His698Tyr Uncertain significance Single submitter
- DCAF5 p.His845Asn Uncertain significance Single submitter
- DCAF5 p.His845Asp Uncertain significance Single submitter
- DCAF5 p.Ile443Met Uncertain significance Single submitter
- DCAF5 p.Ile653Val Uncertain significance Single submitter
- DCAF5 p.Leu483Pro Uncertain significance Single submitter
- DCAF5 p.Leu483Val Uncertain significance Single submitter
- DCAF5 p.Lys665Arg Uncertain significance Single submitter
- DCAF5 p.Met587Leu Uncertain significance Single submitter
- DCAF5 p.Phe733Ser Uncertain significance Single submitter
- DCAF5 p.Pro176Ser Uncertain significance Single submitter
- DCAF5 p.Pro313Leu Uncertain significance Single submitter
- DCAF5 p.Pro501His Uncertain significance Single submitter
- DCAF5 p.Pro629Ser Uncertain significance Single submitter
- DCAF5 p.Pro724Leu Uncertain significance Single submitter
- DCAF5 p.Pro738Arg Uncertain significance Single submitter
- DCAF5 p.Pro741Leu Uncertain significance Single submitter
- DCAF5 p.Ser10Gly Uncertain significance Single submitter
- DCAF5 p.Ser111Gly Uncertain significance Single submitter
- DCAF5 p.Ser533Phe Uncertain significance Single submitter
- DCAF5 p.Ser552Leu Uncertain significance Single submitter
- DCAF5 p.Ser909Asn Uncertain significance Single submitter
- DCAF5 p.Ser917Arg Uncertain significance Single submitter
- DCAF5 p.Thr489Ala Uncertain significance Single submitter
- DCAF5 p.Thr765Ile Uncertain significance Single submitter
- DCAF5 p.Thr827Ala Uncertain significance Single submitter
- DCAF5 p.Thr877Ile Uncertain significance Single submitter
- DCAF5 p.Thr877Pro Uncertain significance Single submitter
- DCAF5 p.Thr897Arg Uncertain significance Single submitter
- DCAF5 p.Tyr615Cys Uncertain significance Single submitter
- DCAF5 p.Tyr615His Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- DCAF5 p.Ala189Pro Uncertain significance Single submitter
- DCAF5 p.Ala405Thr Uncertain significance Single submitter
- DCAF5 p.Arg424His Uncertain significance Single submitter
- DCAF5 p.Arg76Cys Uncertain significance Single submitter
- DCAF5 p.Gly25Arg Uncertain significance Single submitter
- DCAF5 p.Gly782Arg Uncertain significance Single submitter
- DCAF5 p.Phe418Leu Uncertain significance Single submitter
- DCAF5 p.Tyr186Cys Uncertain significance Single submitter
All DCAF5 variants
Likely benign 7
- p.Asn720Lys Single submitter
- p.Asn894Ser Single submitter
- p.Ile603Val Single submitter
- p.Ser872Leu Single submitter
- p.Thr493Ala Single submitter
- p.Thr630Ala Single submitter
- p.Val537Ala Single submitter
Uncertain significance 84
- p.Ala189Pro Single submitter ⚠
- p.Ala250Asp Single submitter ⚠
- p.Ala405Thr Single submitter ⚠
- p.Ala526Thr Single submitter ⚠
- p.Ala647Pro Single submitter ⚠
- p.Ala800Pro Single submitter ⚠
- p.Arg291Cys Single submitter ⚠
- p.Arg375Gln Single submitter ⚠
- p.Arg424His Single submitter ⚠
- p.Arg467His Single submitter ⚠
- p.Arg487Gln Single submitter ⚠
- p.Arg509His Single submitter ⚠
- p.Arg512His Single submitter ⚠
- p.Arg518Cys Single submitter ⚠
- p.Arg551Gln Single submitter ⚠
- p.Arg578Gly Single submitter ⚠
- p.Arg595Gln Single submitter ⚠
- p.Arg646Gln Single submitter ⚠
- p.Arg658Gln Single submitter ⚠
- p.Arg76Cys Single submitter ⚠
- p.Arg77Trp Single submitter ⚠
- p.Arg788Gln Single submitter ⚠
- p.Arg836Cys Single submitter ⚠
- p.Arg836His Single submitter ⚠
- p.Asn185Asp Single submitter ⚠
- p.Asn846Asp Single submitter ⚠
- p.Asn894Asp Single submitter ⚠
- p.Asp164Glu Single submitter ⚠
- p.Asp624Gly Single submitter
- p.Asp722Glu Single submitter ⚠
- p.Asp868His Single submitter ⚠
- p.Cys538Phe Single submitter ⚠
- p.Gln643His Single submitter ⚠
- p.Gln718Lys Single submitter ⚠
- p.Glu826Lys Single submitter ⚠
- p.Glu887Ala Single submitter ⚠
- p.Glu932Ala Single submitter ⚠
- p.Gly25Arg Single submitter ⚠
- p.Gly298Val Single submitter ⚠
- p.Gly317Ser Single submitter ⚠
- p.Gly40Ser Single submitter ⚠
- p.Gly687Arg Single submitter ⚠
- p.Gly6Ala Single submitter ⚠
- p.Gly746Cys Single submitter ⚠
- p.Gly766Asp Single submitter ⚠
- p.Gly769Ser Single submitter ⚠
- p.Gly782Arg Single submitter ⚠
- p.Gly848Arg Single submitter ⚠
- p.Gly915Asp Single submitter ⚠
- p.His24Arg Single submitter ⚠
- p.His52fs Single submitter
- p.His698Tyr Single submitter ⚠
- p.His845Asn Single submitter ⚠
- p.His845Asp Single submitter ⚠
- p.Ile443Met Single submitter ⚠
- p.Ile653Val Single submitter ⚠
- p.Leu483Pro Single submitter ⚠
- p.Leu483Val Single submitter ⚠
- p.Lys665Arg Single submitter ⚠
- p.Met587Leu Single submitter ⚠
- p.Phe418Leu Single submitter ⚠
- p.Phe733Ser Single submitter ⚠
- p.Pro176Ser Single submitter ⚠
- p.Pro313Leu Single submitter ⚠
- p.Pro501His Single submitter ⚠
- p.Pro629Ser Single submitter ⚠
- p.Pro724Leu Single submitter ⚠
- p.Pro738Arg Single submitter ⚠
- p.Pro741Leu Single submitter ⚠
- p.Ser10Gly Single submitter ⚠
- p.Ser111Gly Single submitter ⚠
- p.Ser533Phe Single submitter ⚠
- p.Ser552Leu Single submitter ⚠
- p.Ser909Asn Single submitter ⚠
- p.Ser917Arg Single submitter ⚠
- p.Thr489Ala Single submitter ⚠
- p.Thr765Ile Single submitter ⚠
- p.Thr827Ala Single submitter ⚠
- p.Thr877Ile Single submitter ⚠
- p.Thr877Pro Single submitter ⚠
- p.Thr897Arg Single submitter ⚠
- p.Tyr186Cys Single submitter ⚠
- p.Tyr615Cys Single submitter ⚠
- p.Tyr615His Single submitter ⚠