DCAF6 — 113 ClinVar variants
All ClinVar germline DCAF6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 95 flagged for review →
1 Conflicting · 1 Benign · 4 Likely benign · 107 Uncertain significance
Full DCAF6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 95
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 60
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DCAF6 p.Ala295Val Uncertain significance Single submitter
- DCAF6 p.Ala616Ser Uncertain significance Single submitter
- DCAF6 p.Ala677Val Uncertain significance Single submitter
- DCAF6 p.Arg172Cys Uncertain significance Single submitter
- DCAF6 p.Arg221Gln Uncertain significance Single submitter
- DCAF6 p.Arg235Gln Uncertain significance Single submitter
- DCAF6 p.Arg243Cys Uncertain significance Single submitter
- DCAF6 p.Arg303Gln Uncertain significance Single submitter
- DCAF6 p.Arg309His Uncertain significance Single submitter
- DCAF6 p.Arg30Ser Uncertain significance Single submitter
- DCAF6 p.Arg668His Uncertain significance Single submitter
- DCAF6 p.Arg768Cys Uncertain significance Single submitter
- DCAF6 p.Arg780Trp Uncertain significance Single submitter
- DCAF6 p.Arg797Lys Uncertain significance Single submitter
- DCAF6 p.Asn250Ser Uncertain significance Single submitter
- DCAF6 p.Asn251Asp Uncertain significance Single submitter
- DCAF6 p.Asn539Ser Uncertain significance Single submitter
- DCAF6 p.Asn703Ser Uncertain significance Single submitter
- DCAF6 p.Asp647Asn Uncertain significance Single submitter
- DCAF6 p.Asp735Val Uncertain significance Single submitter
- DCAF6 p.Cys58Tyr Uncertain significance Single submitter
- DCAF6 p.Gln377Glu Uncertain significance Single submitter
- DCAF6 p.Gln444Glu Uncertain significance Single submitter
- DCAF6 p.Glu126Asp Uncertain significance Single submitter
- DCAF6 p.Glu289Asp Uncertain significance Single submitter
- DCAF6 p.Glu597Asp Uncertain significance Single submitter
- DCAF6 p.Glu674Gly Uncertain significance Single submitter
- DCAF6 p.Gly4Ser Uncertain significance Single submitter
- DCAF6 p.Gly52Asp Uncertain significance Single submitter
- DCAF6 p.Gly548Arg Uncertain significance Single submitter
- DCAF6 p.Gly630Arg Uncertain significance Single submitter
- DCAF6 p.Ile203Val Uncertain significance Single submitter
- DCAF6 p.Ile586Thr Uncertain significance Single submitter
- DCAF6 p.Leu158Val Uncertain significance Single submitter
- DCAF6 p.Leu437Val Uncertain significance Single submitter
- DCAF6 p.Leu740Val Uncertain significance Single submitter
- DCAF6 p.Lys179Arg Uncertain significance Single submitter
- DCAF6 p.Lys891Glu Uncertain significance Single submitter
- DCAF6 p.Pro104Ser Uncertain significance Single submitter
- DCAF6 p.Pro24Leu Uncertain significance Single submitter
- DCAF6 p.Pro293Ser Uncertain significance Single submitter
- DCAF6 p.Pro431Leu Uncertain significance Single submitter
- DCAF6 p.Pro545Arg Uncertain significance Single submitter
- DCAF6 p.Pro601Leu Uncertain significance Single submitter
- DCAF6 p.Pro608Arg Uncertain significance Single submitter
- DCAF6 p.Ser438Pro Uncertain significance Single submitter
- DCAF6 p.Ser439Pro Uncertain significance Single submitter
- DCAF6 p.Thr131Ala Uncertain significance Single submitter
- DCAF6 p.Thr143Ala Uncertain significance Single submitter
- DCAF6 p.Thr178Lys Uncertain significance Single submitter
- DCAF6 p.Thr195Met Uncertain significance Single submitter
- DCAF6 p.Thr292Ser Uncertain significance Single submitter
- DCAF6 p.Thr424Pro Uncertain significance Single submitter
- DCAF6 p.Thr713Pro Uncertain significance Single submitter
- DCAF6 p.Thr73Ile Uncertain significance Single submitter
- DCAF6 p.Val125Ile Uncertain significance Single submitter
- DCAF6 p.Val600Ile Uncertain significance Single submitter
- DCAF6 p.Val631Leu Uncertain significance Single submitter
- DCAF6 p.Val637Ile Uncertain significance Single submitter
- DCAF6 p.Val803Ile Uncertain significance Single submitter
Predictors split 35
The independent predictors disagree with each other — read with care.
- DCAF6 p.Arg235Leu Uncertain significance Single submitter
- DCAF6 p.Arg243His Uncertain significance Single submitter
- DCAF6 p.Arg303Leu Uncertain significance Single submitter
- DCAF6 p.Arg30Cys Uncertain significance Single submitter
- DCAF6 p.Arg324Gly Uncertain significance Single submitter
- DCAF6 p.Arg366Gln Uncertain significance Single submitter
- DCAF6 p.Arg3Trp Uncertain significance Single submitter
- DCAF6 p.Arg745Gly Uncertain significance Single submitter
-
DCAF6 p.Arg747Gln
Conflicting
Single submitter
DCAF6-related condition
- DCAF6 p.Arg768His Uncertain significance Single submitter
- DCAF6 p.Arg780Gln Uncertain significance Single submitter
- DCAF6 p.Arg90Leu Uncertain significance Single submitter
- DCAF6 p.Asn152Ser Uncertain significance Single submitter
- DCAF6 p.Asn231Tyr Uncertain significance Single submitter
- DCAF6 p.Asn818Ser Uncertain significance Single submitter
- DCAF6 p.Gln110Arg Uncertain significance Single submitter
- DCAF6 p.Glu948Lys Uncertain significance Single submitter
- DCAF6 p.Ile66Met Uncertain significance Single submitter
- DCAF6 p.Ile89Val Uncertain significance Single submitter
- DCAF6 p.Leu290Phe Uncertain significance Single submitter
- DCAF6 p.Leu86Phe Uncertain significance Single submitter
- DCAF6 p.Met348Thr Uncertain significance Single submitter
- DCAF6 p.Met399Val Uncertain significance Single submitter
- DCAF6 p.Phe777Leu Uncertain significance Single submitter
- DCAF6 p.Ser294Tyr Uncertain significance Single submitter
- DCAF6 p.Thr138Met Uncertain significance Single submitter
- DCAF6 p.Thr171Ile Uncertain significance Single submitter
- DCAF6 p.Thr413Ala Uncertain significance Single submitter
- DCAF6 p.Thr428Ile Uncertain significance Single submitter
- DCAF6 p.Thr565Ile Uncertain significance Single submitter
- DCAF6 p.Thr693Ile Uncertain significance Single submitter
- DCAF6 p.Thr713Ile Likely benign Single submitter
- DCAF6 p.Tyr122His Uncertain significance Single submitter
- DCAF6 p.Val197Ala Uncertain significance Single submitter
- DCAF6 p.Val85Ile Uncertain significance Single submitter
All DCAF6 variants
Conflicting classifications of pathogenicity 1
- p.Arg747Gln Single submitter DCAF6-related condition ⚠
Benign 1
- p.Thr644Ile Multiple submitters
Likely benign 4
- p.Ile641Val Single submitter
- p.Phe599Leu Single submitter
- p.Thr416Ala Single submitter
- p.Thr713Ile Single submitter ⚠
Uncertain significance 107
- p.Ala295Val Single submitter ⚠
- p.Ala482Thr Single submitter
- p.Ala616Ser Single submitter ⚠
- p.Ala677Val Single submitter ⚠
- p.Arg172Cys Single submitter ⚠
- p.Arg221Gln Single submitter ⚠
- p.Arg235Gln Single submitter ⚠
- p.Arg235Leu Single submitter ⚠
- p.Arg243Cys Single submitter ⚠
- p.Arg243His Single submitter ⚠
- p.Arg303Gln Single submitter ⚠
- p.Arg303Leu Single submitter ⚠
- p.Arg309His Single submitter ⚠
- p.Arg30Cys Single submitter ⚠
- p.Arg30Ser Single submitter ⚠
- p.Arg324Gly Single submitter ⚠
- p.Arg366Gln Single submitter ⚠
- p.Arg3Trp Single submitter ⚠
- p.Arg471Cys Single submitter
- p.Arg471His Single submitter
- p.Arg668His Single submitter ⚠
- p.Arg745Gly Single submitter ⚠
- p.Arg768Cys Single submitter ⚠
- p.Arg768His Single submitter ⚠
- p.Arg780Gln Single submitter ⚠
- p.Arg780Trp Single submitter ⚠
- p.Arg797Lys Single submitter ⚠
- p.Arg90Leu Single submitter ⚠
- p.Asn152Ser Single submitter ⚠
- p.Asn231Tyr Single submitter ⚠
- p.Asn250Ser Single submitter ⚠
- p.Asn251Asp Single submitter ⚠
- p.Asn524Lys Single submitter
- p.Asn539Ser Single submitter ⚠
- p.Asn703Ser Single submitter ⚠
- p.Asn818Ser Single submitter ⚠
- p.Asp647Asn Single submitter ⚠
- p.Asp735Val Single submitter ⚠
- p.Cys58Tyr Single submitter ⚠
- p.Gln110Arg Single submitter ⚠
- p.Gln377Glu Single submitter ⚠
- p.Gln444Glu Single submitter ⚠
- p.Gln497His Single submitter
- p.Gln536Arg Single submitter
- p.Glu126Asp Single submitter ⚠
- p.Glu289Asp Single submitter ⚠
- p.Glu534Lys Single submitter
- p.Glu597Asp Single submitter ⚠
- p.Glu674Gly Single submitter ⚠
- p.Glu948Lys Single submitter ⚠
- p.Gly4Ser Single submitter ⚠
- p.Gly528Arg Single submitter
- p.Gly52Asp Single submitter ⚠
- p.Gly548Arg Single submitter ⚠
- p.Gly630Arg Single submitter ⚠
- p.His506Arg Single submitter
- p.Ile203Val Single submitter ⚠
- p.Ile586Thr Single submitter ⚠
- p.Ile66Met Single submitter ⚠
- p.Ile89Val Single submitter ⚠
- p.Leu158Val Single submitter ⚠
- p.Leu290Phe Single submitter ⚠
- p.Leu437Val Single submitter ⚠
- p.Leu532Phe Single submitter
- p.Leu740Val Single submitter ⚠
- p.Leu86Phe Single submitter ⚠
- p.Lys179Arg Single submitter ⚠
- p.Lys891Glu Single submitter ⚠
- p.Met348Thr Single submitter ⚠
- p.Met399Val Single submitter ⚠
- p.Met530Thr Single submitter
- p.Phe461Cys Single submitter
- p.Phe777Leu Single submitter ⚠
- p.Pro104Ser Single submitter ⚠
- p.Pro24Leu Single submitter ⚠
- p.Pro293Ser Single submitter ⚠
- p.Pro431Leu Single submitter ⚠
- p.Pro545Arg Single submitter ⚠
- p.Pro601Leu Single submitter ⚠
- p.Pro608Arg Single submitter ⚠
- p.Ser294Tyr Single submitter ⚠
- p.Ser438Pro Single submitter ⚠
- p.Ser439Pro Single submitter ⚠
- p.Ser520Pro Single submitter
- p.Thr131Ala Single submitter ⚠
- p.Thr138Met Single submitter ⚠
- p.Thr143Ala Single submitter ⚠
- p.Thr171Ile Single submitter ⚠
- p.Thr178Lys Single submitter ⚠
- p.Thr195Met Single submitter ⚠
- p.Thr292Ser Single submitter ⚠
- p.Thr413Ala Single submitter ⚠
- p.Thr424Pro Single submitter ⚠
- p.Thr428Ile Single submitter ⚠
- p.Thr494Asn Single submitter
- p.Thr565Ile Single submitter ⚠
- p.Thr693Ile Single submitter ⚠
- p.Thr713Pro Single submitter ⚠
- p.Thr73Ile Single submitter ⚠
- p.Tyr122His Single submitter ⚠
- p.Val125Ile Single submitter ⚠
- p.Val197Ala Single submitter ⚠
- p.Val600Ile Single submitter ⚠
- p.Val631Leu Single submitter ⚠
- p.Val637Ile Single submitter ⚠
- p.Val803Ile Single submitter ⚠
- p.Val85Ile Single submitter ⚠