DCAF8L1 — 70 ClinVar variants
All ClinVar germline DCAF8L1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 59 flagged for review →
11 Likely benign · 59 Uncertain significance
Full DCAF8L1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 59
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 52
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DCAF8L1 p.Ala149Val Uncertain significance Single submitter
- DCAF8L1 p.Ala160Asp Uncertain significance Single submitter
- DCAF8L1 p.Ala196Ser Uncertain significance Single submitter
- DCAF8L1 p.Ala257Val Uncertain significance Single submitter
- DCAF8L1 p.Ala34Val Uncertain significance Single submitter
- DCAF8L1 p.Ala43Thr Uncertain significance Single submitter
- DCAF8L1 p.Ala559Thr Uncertain significance Single submitter
- DCAF8L1 p.Ala63Val Uncertain significance Single submitter
- DCAF8L1 p.Arg122Pro Uncertain significance Single submitter
- DCAF8L1 p.Arg154Cys Uncertain significance Single submitter
- DCAF8L1 p.Arg162His Uncertain significance Single submitter
- DCAF8L1 p.Arg171Cys Uncertain significance Single submitter
- DCAF8L1 p.Arg187Ser Uncertain significance Single submitter
- DCAF8L1 p.Arg210Gln Uncertain significance Single submitter
- DCAF8L1 p.Arg219Ser Uncertain significance Single submitter
- DCAF8L1 p.Arg449Gln Uncertain significance Single submitter
- DCAF8L1 p.Arg546Cys Uncertain significance Single submitter
- DCAF8L1 p.Arg549Gln Uncertain significance Single submitter
- DCAF8L1 p.Arg553His Uncertain significance Single submitter
- DCAF8L1 p.Asn67Ser Uncertain significance Single submitter
- DCAF8L1 p.Asp332Gly Uncertain significance Single submitter
- DCAF8L1 p.Gln357Arg Uncertain significance Single submitter
- DCAF8L1 p.Gln557Glu Uncertain significance Single submitter
- DCAF8L1 p.Glu110Asp Uncertain significance Single submitter
- DCAF8L1 p.Glu25Lys Uncertain significance Single submitter
- DCAF8L1 p.Glu277Lys Uncertain significance Single submitter
- DCAF8L1 p.Glu40Asp Uncertain significance Single submitter
- DCAF8L1 p.Glu82Ala Uncertain significance Single submitter
- DCAF8L1 p.Gly124Ser Uncertain significance Single submitter
- DCAF8L1 p.Gly215Ser Uncertain significance Single submitter
- DCAF8L1 p.Gly49Arg Uncertain significance Single submitter
- DCAF8L1 p.Gly52Asp Uncertain significance Single submitter
- DCAF8L1 p.Gly591Ala Uncertain significance Single submitter
- DCAF8L1 p.His128Tyr Uncertain significance Single submitter
- DCAF8L1 p.Leu158Val Uncertain significance Single submitter
- DCAF8L1 p.Met107Lys Uncertain significance Single submitter
- DCAF8L1 p.Met41Ile Uncertain significance Single submitter
- DCAF8L1 p.Pro92Leu Uncertain significance Single submitter
- DCAF8L1 p.Ser145Leu Uncertain significance Single submitter
- DCAF8L1 p.Ser169Arg Uncertain significance Single submitter
- DCAF8L1 p.Thr126Ser Uncertain significance Single submitter
- DCAF8L1 p.Thr339Ala Uncertain significance Single submitter
- DCAF8L1 p.Thr33Ala Uncertain significance Single submitter
- DCAF8L1 p.Thr403Ala Uncertain significance Single submitter
- DCAF8L1 p.Thr44Ser Uncertain significance Single submitter
- DCAF8L1 p.Thr519Ile Uncertain significance Single submitter
- DCAF8L1 p.Thr586Ala Uncertain significance Single submitter
- DCAF8L1 p.Thr70Ala Uncertain significance Single submitter
- DCAF8L1 p.Thr98Ser Uncertain significance Single submitter
- DCAF8L1 p.Val359Leu Uncertain significance Single submitter
- DCAF8L1 p.Val524Ala Uncertain significance Single submitter
- DCAF8L1 p.Val552Leu Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- DCAF8L1 p.Arg449Trp Uncertain significance Single submitter
- DCAF8L1 p.Arg532Leu Uncertain significance Single submitter
- DCAF8L1 p.Gln137Pro Uncertain significance Single submitter
- DCAF8L1 p.His554Asp Uncertain significance Single submitter
- DCAF8L1 p.Leu487Phe Uncertain significance Single submitter
- DCAF8L1 p.Pro151Thr Uncertain significance Single submitter
- DCAF8L1 p.Thr159Ile Uncertain significance Single submitter
All DCAF8L1 variants
Likely benign 11
- p.Arg187Cys Multiple submitters
- p.Ala31= Single submitter
- p.Ala31Val Single submitter
- p.Asp129Glu Single submitter
- p.Gln561His Single submitter
- p.His400= Single submitter
- p.Ile39Thr Single submitter
- p.Met107Ile Single submitter
- p.Ser153Pro Single submitter
- p.Thr126Ala Single submitter
- p.Val396Ile Single submitter
Uncertain significance 59
- p.Ala149Val Single submitter ⚠
- p.Ala160Asp Single submitter ⚠
- p.Ala196Ser Single submitter ⚠
- p.Ala257Val Single submitter ⚠
- p.Ala34Val Single submitter ⚠
- p.Ala43Thr Single submitter ⚠
- p.Ala559Thr Single submitter ⚠
- p.Ala63Val Single submitter ⚠
- p.Arg122Pro Single submitter ⚠
- p.Arg154Cys Single submitter ⚠
- p.Arg162His Single submitter ⚠
- p.Arg171Cys Single submitter ⚠
- p.Arg187Ser Single submitter ⚠
- p.Arg210Gln Single submitter ⚠
- p.Arg219Ser Single submitter ⚠
- p.Arg449Gln Single submitter ⚠
- p.Arg449Trp Single submitter ⚠
- p.Arg532Leu Single submitter ⚠
- p.Arg546Cys Single submitter ⚠
- p.Arg549Gln Single submitter ⚠
- p.Arg553His Single submitter ⚠
- p.Asn67Ser Single submitter ⚠
- p.Asp332Gly Single submitter ⚠
- p.Gln137Pro Single submitter ⚠
- p.Gln357Arg Single submitter ⚠
- p.Gln557Glu Single submitter ⚠
- p.Glu110Asp Single submitter ⚠
- p.Glu25Lys Single submitter ⚠
- p.Glu277Lys Single submitter ⚠
- p.Glu40Asp Single submitter ⚠
- p.Glu82Ala Single submitter ⚠
- p.Gly124Ser Single submitter ⚠
- p.Gly215Ser Single submitter ⚠
- p.Gly49Arg Single submitter ⚠
- p.Gly52Asp Single submitter ⚠
- p.Gly591Ala Single submitter ⚠
- p.His128Tyr Single submitter ⚠
- p.His554Asp Single submitter ⚠
- p.Leu158Val Single submitter ⚠
- p.Leu487Phe Single submitter ⚠
- p.Met107Lys Single submitter ⚠
- p.Met41Ile Single submitter ⚠
- p.Pro151Thr Single submitter ⚠
- p.Pro92Leu Single submitter ⚠
- p.Ser145Leu Single submitter ⚠
- p.Ser169Arg Single submitter ⚠
- p.Thr126Ser Single submitter ⚠
- p.Thr159Ile Single submitter ⚠
- p.Thr339Ala Single submitter ⚠
- p.Thr33Ala Single submitter ⚠
- p.Thr403Ala Single submitter ⚠
- p.Thr44Ser Single submitter ⚠
- p.Thr519Ile Single submitter ⚠
- p.Thr586Ala Single submitter ⚠
- p.Thr70Ala Single submitter ⚠
- p.Thr98Ser Single submitter ⚠
- p.Val359Leu Single submitter ⚠
- p.Val524Ala Single submitter ⚠
- p.Val552Leu Single submitter ⚠