DCAF8L2 — 13 ClinVar variants
All ClinVar germline DCAF8L2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 7 flagged for review →
6 Likely benign · 7 Uncertain significance
Full DCAF8L2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 7
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 2
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 5
The independent predictors disagree with each other — read with care.
All DCAF8L2 variants
Likely benign 6
- p.Asp444Glu Single submitter
- p.Glu145= Single submitter
- p.His194Arg Single submitter
- p.Leu580= Single submitter
- p.Met629Leu Single submitter
- p.Thr373Ser Single submitter
Uncertain significance 7
- p.Arg462Lys Single submitter ⚠
- p.Asn378Ser Single submitter ⚠
- p.Cys209Trp Single submitter ⚠
- p.His415Tyr Single submitter ⚠
- p.His453Leu Single submitter ⚠
- p.Tyr478Cys Single submitter ⚠
- p.Val374Met Single submitter ⚠