DCAKD — 46 ClinVar variants
All ClinVar germline DCAKD variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 44 flagged for review →
2 Likely benign · 44 Uncertain significance
Full DCAKD gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 44
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 18
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DCAKD p.Ala214Thr Uncertain significance Single submitter
- DCAKD p.Ala214Val Uncertain significance Single submitter
- DCAKD p.Arg105Gln Uncertain significance Single submitter
- DCAKD p.Arg143Trp Uncertain significance Single submitter
- DCAKD p.Arg147Trp Uncertain significance Single submitter
- DCAKD p.Arg173His Uncertain significance Single submitter
- DCAKD p.Arg66Cys Uncertain significance Single submitter
- DCAKD p.Arg80Trp Uncertain significance Single submitter
- DCAKD p.Asn84Lys Uncertain significance Single submitter
- DCAKD p.Asp113Asn Uncertain significance Single submitter
- DCAKD p.Asp63Asn Uncertain significance Single submitter
- DCAKD p.Gln140Lys Uncertain significance Single submitter
- DCAKD p.Leu104Pro Uncertain significance Single submitter
- DCAKD p.Met34Val Uncertain significance Single submitter
- DCAKD p.Pro204Leu Uncertain significance Single submitter
- DCAKD p.Thr99Met Uncertain significance Single submitter
- DCAKD p.Tyr107His Uncertain significance Single submitter
- DCAKD p.Val110Met Uncertain significance Single submitter
Predictors split 26
The independent predictors disagree with each other — read with care.
- DCAKD p.Asp136Asn Uncertain significance Multiple submitters
- DCAKD p.Arg152Cys Uncertain significance Single submitter
- DCAKD p.Arg152His Uncertain significance Single submitter
- DCAKD p.Arg170His Uncertain significance Single submitter
- DCAKD p.Arg170Leu Uncertain significance Single submitter
- DCAKD p.Arg198Cys Uncertain significance Single submitter
- DCAKD p.Arg198His Uncertain significance Single submitter
- DCAKD p.Arg36Trp Uncertain significance Single submitter
- DCAKD p.Arg47Gln Uncertain significance Single submitter
- DCAKD p.Arg48His Uncertain significance Single submitter
- DCAKD p.Arg79Trp Uncertain significance Single submitter
- DCAKD p.Arg80Gln Uncertain significance Single submitter
- DCAKD p.Gln140Glu Uncertain significance Single submitter
- DCAKD p.Glu181Lys Uncertain significance Single submitter
- DCAKD p.Gly62Ser Uncertain significance Single submitter
- DCAKD p.His193Tyr Uncertain significance Single submitter
- DCAKD p.Ile49Val Uncertain significance Single submitter
- DCAKD p.Lys93Asn Uncertain significance Single submitter
- DCAKD p.Met171Val Uncertain significance Single submitter
- DCAKD p.Ser179Leu Uncertain significance Single submitter
- DCAKD p.Thr87Ile Uncertain significance Single submitter
- DCAKD p.Tyr134His Uncertain significance Single submitter
- DCAKD p.Tyr221His Uncertain significance Single submitter
- DCAKD p.Val33Met Uncertain significance Single submitter
- DCAKD p.Val39Met Uncertain significance Single submitter
- DCAKD p.Val50Ile Uncertain significance Single submitter
All DCAKD variants
Likely benign 2
- p.Gly9fs Single submitter
- p.His225Arg Single submitter
Uncertain significance 44
- p.Asp136Asn Multiple submitters ⚠
- p.Ala214Thr Single submitter ⚠
- p.Ala214Val Single submitter ⚠
- p.Arg105Gln Single submitter ⚠
- p.Arg143Trp Single submitter ⚠
- p.Arg147Trp Single submitter ⚠
- p.Arg152Cys Single submitter ⚠
- p.Arg152His Single submitter ⚠
- p.Arg170His Single submitter ⚠
- p.Arg170Leu Single submitter ⚠
- p.Arg173His Single submitter ⚠
- p.Arg198Cys Single submitter ⚠
- p.Arg198His Single submitter ⚠
- p.Arg36Trp Single submitter ⚠
- p.Arg47Gln Single submitter ⚠
- p.Arg48His Single submitter ⚠
- p.Arg66Cys Single submitter ⚠
- p.Arg79Trp Single submitter ⚠
- p.Arg80Gln Single submitter ⚠
- p.Arg80Trp Single submitter ⚠
- p.Asn84Lys Single submitter ⚠
- p.Asp113Asn Single submitter ⚠
- p.Asp63Asn Single submitter ⚠
- p.Gln140Glu Single submitter ⚠
- p.Gln140Lys Single submitter ⚠
- p.Glu181Lys Single submitter ⚠
- p.Gly62Ser Single submitter ⚠
- p.His193Tyr Single submitter ⚠
- p.Ile49Val Single submitter ⚠
- p.Leu104Pro Single submitter ⚠
- p.Lys93Asn Single submitter ⚠
- p.Met171Val Single submitter ⚠
- p.Met34Val Single submitter ⚠
- p.Pro204Leu Single submitter ⚠
- p.Ser179Leu Single submitter ⚠
- p.Thr87Ile Single submitter ⚠
- p.Thr99Met Single submitter ⚠
- p.Tyr107His Single submitter ⚠
- p.Tyr134His Single submitter ⚠
- p.Tyr221His Single submitter ⚠
- p.Val110Met Single submitter ⚠
- p.Val33Met Single submitter ⚠
- p.Val39Met Single submitter ⚠
- p.Val50Ile Single submitter ⚠