DCBLD1 — 74 ClinVar variants
All ClinVar germline DCBLD1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 67 flagged for review →
6 Likely benign · 68 Uncertain significance
Full DCBLD1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 67
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 54
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DCBLD1 p.Asp151Asn Uncertain significance Multiple submitters
- DCBLD1 p.Ala15Ser Uncertain significance Single submitter
- DCBLD1 p.Ala182Val Uncertain significance Single submitter
- DCBLD1 p.Ala28Val Uncertain significance Single submitter
- DCBLD1 p.Ala479Asp Uncertain significance Single submitter
- DCBLD1 p.Ala509Ser Uncertain significance Single submitter
- DCBLD1 p.Ala5Gly Uncertain significance Single submitter
- DCBLD1 p.Ala95Val Uncertain significance Single submitter
- DCBLD1 p.Arg13Gln Uncertain significance Single submitter
- DCBLD1 p.Arg222Gly Uncertain significance Single submitter
- DCBLD1 p.Arg311Gln Uncertain significance Single submitter
- DCBLD1 p.Arg31Gly Uncertain significance Single submitter
- DCBLD1 p.Arg376Gln Uncertain significance Single submitter
- DCBLD1 p.Arg393Trp Uncertain significance Single submitter
- DCBLD1 p.Asn306Asp Uncertain significance Single submitter
- DCBLD1 p.Asn336Asp Uncertain significance Single submitter
- DCBLD1 p.Asn364His Uncertain significance Single submitter
- DCBLD1 p.Asp303Asn Uncertain significance Single submitter
- DCBLD1 p.Gln216Glu Uncertain significance Single submitter
- DCBLD1 p.Gln33Arg Uncertain significance Single submitter
- DCBLD1 p.Glu525Gly Uncertain significance Single submitter
- DCBLD1 p.Gly109Asp Uncertain significance Single submitter
- DCBLD1 p.Gly302Asp Uncertain significance Single submitter
- DCBLD1 p.Gly51Cys Uncertain significance Single submitter
- DCBLD1 p.His308Tyr Uncertain significance Single submitter
- DCBLD1 p.Ile387Val Uncertain significance Single submitter
- DCBLD1 p.Ile461Val Uncertain significance Single submitter
- DCBLD1 p.Ile533Val Uncertain significance Single submitter
- DCBLD1 p.Leu99Val Uncertain significance Single submitter
- DCBLD1 p.Lys349Arg Uncertain significance Single submitter
- DCBLD1 p.Met189Ile Uncertain significance Single submitter
- DCBLD1 p.Met53Val Uncertain significance Single submitter
- DCBLD1 p.Pro153Ser Uncertain significance Single submitter
- DCBLD1 p.Pro175Ser Uncertain significance Single submitter
- DCBLD1 p.Pro29Gln Uncertain significance Single submitter
- DCBLD1 p.Ser105Leu Uncertain significance Single submitter
- DCBLD1 p.Ser134Ile Uncertain significance Single submitter
- DCBLD1 p.Ser186Pro Uncertain significance Single submitter
- DCBLD1 p.Ser242Cys Uncertain significance Single submitter
- DCBLD1 p.Ser301Leu Uncertain significance Single submitter
- DCBLD1 p.Ser431Gly Uncertain significance Single submitter
- DCBLD1 p.Thr102Ile Uncertain significance Single submitter
- DCBLD1 p.Thr325Arg Uncertain significance Single submitter
- DCBLD1 p.Thr442Lys Uncertain significance Single submitter
- DCBLD1 p.Thr450Ile Uncertain significance Single submitter
- DCBLD1 p.Thr457Ala Uncertain significance Single submitter
- DCBLD1 p.Thr457Arg Uncertain significance Single submitter
- DCBLD1 p.Tyr147Cys Uncertain significance Single submitter
- DCBLD1 p.Tyr490His Uncertain significance Single submitter
- DCBLD1 p.Val130Ile Uncertain significance Single submitter
- DCBLD1 p.Val190Ile Uncertain significance Single submitter
- DCBLD1 p.Val368Leu Uncertain significance Single submitter
- DCBLD1 p.Val459Met Uncertain significance Single submitter
- DCBLD1 p.Val74Ala Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- DCBLD1 p.Ala206Thr Uncertain significance Single submitter
- DCBLD1 p.Arg131Cys Uncertain significance Single submitter
- DCBLD1 p.Arg194Ser Uncertain significance Single submitter
- DCBLD1 p.Arg222Cys Uncertain significance Single submitter
- DCBLD1 p.Arg328Ser Uncertain significance Single submitter
- DCBLD1 p.Arg83Gly Uncertain significance Single submitter
- DCBLD1 p.Glu169Ala Uncertain significance Single submitter
- DCBLD1 p.Ile461Met Uncertain significance Single submitter
- DCBLD1 p.Leu318Phe Uncertain significance Single submitter
- DCBLD1 p.Phe508Ser Uncertain significance Single submitter
- DCBLD1 p.Pro63His Uncertain significance Single submitter
- DCBLD1 p.Ser353Tyr Uncertain significance Single submitter
- DCBLD1 p.Val392Met Uncertain significance Single submitter
All DCBLD1 variants
Likely benign 6
- p.Ala14= Single submitter
- p.Arg424His Single submitter
- p.Gly265Arg Single submitter
- p.Ser126Asn Single submitter
- p.Ser429Asn Single submitter
- p.Val181Ile Single submitter
Uncertain significance 68
- p.Asp151Asn Multiple submitters ⚠
- p.Ala15Ser Single submitter ⚠
- p.Ala182Val Single submitter ⚠
- p.Ala206Thr Single submitter ⚠
- p.Ala28Val Single submitter ⚠
- p.Ala479Asp Single submitter ⚠
- p.Ala509Ser Single submitter ⚠
- p.Ala5Gly Single submitter ⚠
- p.Ala95Val Single submitter ⚠
- p.Arg131Cys Single submitter ⚠
- p.Arg13Gln Single submitter ⚠
- p.Arg194Ser Single submitter ⚠
- p.Arg222Cys Single submitter ⚠
- p.Arg222Gly Single submitter ⚠
- p.Arg311Gln Single submitter ⚠
- p.Arg31Gly Single submitter ⚠
- p.Arg328Ser Single submitter ⚠
- p.Arg376Gln Single submitter ⚠
- p.Arg393Trp Single submitter ⚠
- p.Arg83Gly Single submitter ⚠
- p.Asn306Asp Single submitter ⚠
- p.Asn336Asp Single submitter ⚠
- p.Asn364His Single submitter ⚠
- p.Asp303Asn Single submitter ⚠
- p.Gln216Glu Single submitter ⚠
- p.Gln33Arg Single submitter ⚠
- p.Glu169Ala Single submitter ⚠
- p.Glu525Gly Single submitter ⚠
- p.Gly109Asp Single submitter ⚠
- p.Gly302Asp Single submitter ⚠
- p.Gly51Cys Single submitter ⚠
- p.His308Tyr Single submitter ⚠
- p.Ile387Val Single submitter ⚠
- p.Ile461Met Single submitter ⚠
- p.Ile461Val Single submitter ⚠
- p.Ile533Val Single submitter ⚠
- p.Leu318Phe Single submitter ⚠
- p.Leu99Val Single submitter ⚠
- p.Lys349Arg Single submitter ⚠
- p.Met189Ile Single submitter ⚠
- p.Met53Val Single submitter ⚠
- p.Phe508Ser Single submitter ⚠
- p.Pro153Ser Single submitter ⚠
- p.Pro175Ser Single submitter ⚠
- p.Pro29Gln Single submitter ⚠
- p.Pro63Arg Single submitter
- p.Pro63His Single submitter ⚠
- p.Ser105Leu Single submitter ⚠
- p.Ser134Ile Single submitter ⚠
- p.Ser186Pro Single submitter ⚠
- p.Ser242Cys Single submitter ⚠
- p.Ser301Leu Single submitter ⚠
- p.Ser353Tyr Single submitter ⚠
- p.Ser431Gly Single submitter ⚠
- p.Thr102Ile Single submitter ⚠
- p.Thr325Arg Single submitter ⚠
- p.Thr442Lys Single submitter ⚠
- p.Thr450Ile Single submitter ⚠
- p.Thr457Ala Single submitter ⚠
- p.Thr457Arg Single submitter ⚠
- p.Tyr147Cys Single submitter ⚠
- p.Tyr490His Single submitter ⚠
- p.Val130Ile Single submitter ⚠
- p.Val190Ile Single submitter ⚠
- p.Val368Leu Single submitter ⚠
- p.Val392Met Single submitter ⚠
- p.Val459Met Single submitter ⚠
- p.Val74Ala Single submitter ⚠