DCBLD2 — 99 ClinVar variants
All ClinVar germline DCBLD2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 91 flagged for review →
1 Benign · 7 Likely benign · 91 Uncertain significance
Full DCBLD2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 91
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 54
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DCBLD2 p.Ala24Ser Uncertain significance Single submitter
- DCBLD2 p.Ala304Glu Uncertain significance Single submitter
- DCBLD2 p.Ala304Thr Uncertain significance Single submitter
- DCBLD2 p.Ala341Thr Uncertain significance Single submitter
- DCBLD2 p.Ala5Ser Uncertain significance Single submitter
- DCBLD2 p.Ala667Thr Uncertain significance Single submitter
- DCBLD2 p.Arg112His Uncertain significance Single submitter
- DCBLD2 p.Arg596His Uncertain significance Single submitter
- DCBLD2 p.Arg721Lys Uncertain significance Single submitter
- DCBLD2 p.Asn135Ser Uncertain significance Single submitter
- DCBLD2 p.Asn155Lys Uncertain significance Single submitter
- DCBLD2 p.Asn522Asp Uncertain significance Single submitter
- DCBLD2 p.Asn716Ser Uncertain significance Single submitter
- DCBLD2 p.Asp124His Uncertain significance Single submitter
- DCBLD2 p.Asp471Gly Uncertain significance Single submitter
- DCBLD2 p.Asp571Asn Uncertain significance Single submitter
- DCBLD2 p.Asp769Tyr Uncertain significance Single submitter
- DCBLD2 p.Cys12Trp Uncertain significance Single submitter
- DCBLD2 p.Gln729Lys Uncertain significance Single submitter
- DCBLD2 p.Gln91Lys Uncertain significance Single submitter
- DCBLD2 p.Glu601Lys Uncertain significance Single submitter
- DCBLD2 p.Glu80Asp Uncertain significance Single submitter
- DCBLD2 p.Gly136Val Uncertain significance Single submitter
- DCBLD2 p.Gly162Asp Uncertain significance Single submitter
- DCBLD2 p.Gly563Asp Uncertain significance Single submitter
- DCBLD2 p.Gly659Glu Uncertain significance Single submitter
- DCBLD2 p.Gly741Asp Uncertain significance Single submitter
- DCBLD2 p.His156Arg Uncertain significance Single submitter
- DCBLD2 p.His156Asn Uncertain significance Single submitter
- DCBLD2 p.His664Arg Uncertain significance Single submitter
- DCBLD2 p.Ile165Val Uncertain significance Single submitter
- DCBLD2 p.Ile629Thr Uncertain significance Single submitter
- DCBLD2 p.Leu284Ile Uncertain significance Single submitter
- DCBLD2 p.Met238Thr Uncertain significance Single submitter
- DCBLD2 p.Met371Ile Uncertain significance Single submitter
- DCBLD2 p.Met371Val Uncertain significance Single submitter
- DCBLD2 p.Met47Val Uncertain significance Single submitter
- DCBLD2 p.Phe50Leu Uncertain significance Single submitter
- DCBLD2 p.Pro16Leu Uncertain significance Single submitter
- DCBLD2 p.Pro306Leu Uncertain significance Single submitter
- DCBLD2 p.Pro338Leu Uncertain significance Single submitter
- DCBLD2 p.Pro709Ser Uncertain significance Single submitter
- DCBLD2 p.Pro710Gln Uncertain significance Single submitter
- DCBLD2 p.Pro710Leu Uncertain significance Single submitter
- DCBLD2 p.Thr345Ile Uncertain significance Single submitter
- DCBLD2 p.Thr561Pro Uncertain significance Single submitter
- DCBLD2 p.Thr85Lys Uncertain significance Single submitter
- DCBLD2 p.Tyr147Phe Uncertain significance Single submitter
- DCBLD2 p.Tyr230Cys Uncertain significance Single submitter
- DCBLD2 p.Tyr293Ser Uncertain significance Single submitter
- DCBLD2 p.Val273Ile Uncertain significance Single submitter
- DCBLD2 p.Val277Met Uncertain significance Single submitter
- DCBLD2 p.Val549Ala Uncertain significance Single submitter
- DCBLD2 p.Val712Met Uncertain significance Single submitter
Predictors split 37
The independent predictors disagree with each other — read with care.
- DCBLD2 p.Ala182Thr Uncertain significance Single submitter
- DCBLD2 p.Ala304Val Uncertain significance Single submitter
- DCBLD2 p.Ala482Asp Uncertain significance Single submitter
- DCBLD2 p.Arg104Cys Uncertain significance Single submitter
- DCBLD2 p.Arg112Cys Uncertain significance Single submitter
- DCBLD2 p.Arg19Trp Uncertain significance Single submitter
- DCBLD2 p.Arg417Cys Uncertain significance Single submitter
- DCBLD2 p.Arg427His Uncertain significance Single submitter
- DCBLD2 p.Arg456Cys Uncertain significance Single submitter
- DCBLD2 p.Arg456His Uncertain significance Single submitter
- DCBLD2 p.Arg467Gln Uncertain significance Single submitter
- DCBLD2 p.Arg596Cys Uncertain significance Single submitter
- DCBLD2 p.Asp733Gly Uncertain significance Single submitter
- DCBLD2 p.Cys12Phe Uncertain significance Single submitter
- DCBLD2 p.Glu266Lys Uncertain significance Single submitter
- DCBLD2 p.Ile258Thr Uncertain significance Single submitter
- DCBLD2 p.Leu216Pro Uncertain significance Single submitter
- DCBLD2 p.Leu446Val Uncertain significance Single submitter
- DCBLD2 p.Leu61Phe Uncertain significance Single submitter
- DCBLD2 p.Leu633Phe Uncertain significance Single submitter
- DCBLD2 p.Met539Ile Uncertain significance Single submitter
- DCBLD2 p.Pro16Thr Uncertain significance Single submitter
- DCBLD2 p.Pro478Leu Uncertain significance Single submitter
- DCBLD2 p.Pro487Leu Uncertain significance Single submitter
- DCBLD2 p.Pro48Ser Uncertain significance Single submitter
- DCBLD2 p.Ser208Gly Uncertain significance Single submitter
- DCBLD2 p.Ser35Phe Uncertain significance Single submitter
- DCBLD2 p.Ser379Phe Uncertain significance Single submitter
- DCBLD2 p.Ser511Asn Uncertain significance Single submitter
- DCBLD2 p.Ser96Arg Uncertain significance Single submitter
- DCBLD2 p.Thr490Arg Uncertain significance Single submitter
- DCBLD2 p.Thr612Ile Uncertain significance Single submitter
- DCBLD2 p.Thr673Met Uncertain significance Single submitter
- DCBLD2 p.Trp575Cys Uncertain significance Single submitter
- DCBLD2 p.Val519Ile Uncertain significance Single submitter
- DCBLD2 p.Val538Ala Uncertain significance Single submitter
-
DCBLD2 p.Asp388Asn
Likely benign
No assertion criteria
DCBLD2-related disorder
All DCBLD2 variants
Benign 1
- p.Lys391= Multiple submitters
Likely benign 7
- p.Gly162Ser Single submitter
- p.Leu59= Single submitter
- p.Phe45Ser Single submitter
- p.Thr704Ala Single submitter
- p.Val693Ala Single submitter
- p.Asp388Asn No assertion criteria DCBLD2-related disorder ⚠
- p.Ile672Val No assertion criteria DCBLD2-related disorder
Uncertain significance 91
- p.Ala182Thr Single submitter ⚠
- p.Ala24Ser Single submitter ⚠
- p.Ala304Glu Single submitter ⚠
- p.Ala304Thr Single submitter ⚠
- p.Ala304Val Single submitter ⚠
- p.Ala341Thr Single submitter ⚠
- p.Ala482Asp Single submitter ⚠
- p.Ala5Ser Single submitter ⚠
- p.Ala667Thr Single submitter ⚠
- p.Arg104Cys Single submitter ⚠
- p.Arg112Cys Single submitter ⚠
- p.Arg112His Single submitter ⚠
- p.Arg19Trp Single submitter ⚠
- p.Arg417Cys Single submitter ⚠
- p.Arg427His Single submitter ⚠
- p.Arg456Cys Single submitter ⚠
- p.Arg456His Single submitter ⚠
- p.Arg467Gln Single submitter ⚠
- p.Arg596Cys Single submitter ⚠
- p.Arg596His Single submitter ⚠
- p.Arg721Lys Single submitter ⚠
- p.Asn135Ser Single submitter ⚠
- p.Asn155Lys Single submitter ⚠
- p.Asn522Asp Single submitter ⚠
- p.Asn716Ser Single submitter ⚠
- p.Asp124His Single submitter ⚠
- p.Asp471Gly Single submitter ⚠
- p.Asp571Asn Single submitter ⚠
- p.Asp733Gly Single submitter ⚠
- p.Asp769Tyr Single submitter ⚠
- p.Cys12Phe Single submitter ⚠
- p.Cys12Trp Single submitter ⚠
- p.Gln729Lys Single submitter ⚠
- p.Gln91Lys Single submitter ⚠
- p.Glu266Lys Single submitter ⚠
- p.Glu601Lys Single submitter ⚠
- p.Glu80Asp Single submitter ⚠
- p.Gly136Val Single submitter ⚠
- p.Gly162Asp Single submitter ⚠
- p.Gly563Asp Single submitter ⚠
- p.Gly659Glu Single submitter ⚠
- p.Gly741Asp Single submitter ⚠
- p.His156Arg Single submitter ⚠
- p.His156Asn Single submitter ⚠
- p.His664Arg Single submitter ⚠
- p.Ile165Val Single submitter ⚠
- p.Ile258Thr Single submitter ⚠
- p.Ile629Thr Single submitter ⚠
- p.Leu216Pro Single submitter ⚠
- p.Leu284Ile Single submitter ⚠
- p.Leu446Val Single submitter ⚠
- p.Leu61Phe Single submitter ⚠
- p.Leu633Phe Single submitter ⚠
- p.Met238Thr Single submitter ⚠
- p.Met371Ile Single submitter ⚠
- p.Met371Val Single submitter ⚠
- p.Met47Val Single submitter ⚠
- p.Met539Ile Single submitter ⚠
- p.Phe50Leu Single submitter ⚠
- p.Pro16Leu Single submitter ⚠
- p.Pro16Thr Single submitter ⚠
- p.Pro306Leu Single submitter ⚠
- p.Pro338Leu Single submitter ⚠
- p.Pro478Leu Single submitter ⚠
- p.Pro487Leu Single submitter ⚠
- p.Pro48Ser Single submitter ⚠
- p.Pro709Ser Single submitter ⚠
- p.Pro710Gln Single submitter ⚠
- p.Pro710Leu Single submitter ⚠
- p.Ser208Gly Single submitter ⚠
- p.Ser35Phe Single submitter ⚠
- p.Ser379Phe Single submitter ⚠
- p.Ser511Asn Single submitter ⚠
- p.Ser96Arg Single submitter ⚠
- p.Thr345Ile Single submitter ⚠
- p.Thr490Arg Single submitter ⚠
- p.Thr561Pro Single submitter ⚠
- p.Thr612Ile Single submitter ⚠
- p.Thr673Met Single submitter ⚠
- p.Thr85Lys Single submitter ⚠
- p.Trp27Ter Single submitter
- p.Trp575Cys Single submitter ⚠
- p.Tyr147Phe Single submitter ⚠
- p.Tyr230Cys Single submitter ⚠
- p.Tyr293Ser Single submitter ⚠
- p.Val273Ile Single submitter ⚠
- p.Val277Met Single submitter ⚠
- p.Val519Ile Single submitter ⚠
- p.Val538Ala Single submitter ⚠
- p.Val549Ala Single submitter ⚠
- p.Val712Met Single submitter ⚠