DCDC2B — 56 ClinVar variants
All ClinVar germline DCDC2B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 55 flagged for review →
1 Benign · 1 Likely benign · 54 Uncertain significance
Full DCDC2B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 55
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 29
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DCDC2B p.Ala125Pro Uncertain significance Single submitter
- DCDC2B p.Ala187Gly Uncertain significance Single submitter
- DCDC2B p.Ala239Ser Uncertain significance Single submitter
- DCDC2B p.Ala291Thr Uncertain significance Single submitter
- DCDC2B p.Ala346Val Uncertain significance Single submitter
- DCDC2B p.Ala55Ser Uncertain significance Single submitter
- DCDC2B p.Ala55Val Uncertain significance Single submitter
- DCDC2B p.Ala69Glu Uncertain significance Single submitter
- DCDC2B p.Asp207Asn Uncertain significance Single submitter
- DCDC2B p.Asp97Gly Uncertain significance Single submitter
- DCDC2B p.Cys115Tyr Uncertain significance Single submitter
- DCDC2B p.Glu204Val Uncertain significance Single submitter
- DCDC2B p.Gly126Asp Uncertain significance Single submitter
- DCDC2B p.Gly137Ala Uncertain significance Single submitter
- DCDC2B p.Gly17Glu Uncertain significance Single submitter
- DCDC2B p.Gly223Asp Uncertain significance Single submitter
- DCDC2B p.His93Arg Uncertain significance Single submitter
- DCDC2B p.Ile119Thr Uncertain significance Single submitter
- DCDC2B p.Leu162Pro Uncertain significance Single submitter
- DCDC2B p.Leu183Val Uncertain significance Single submitter
- DCDC2B p.Phe144Cys Uncertain significance Single submitter
- DCDC2B p.Ser230Leu Uncertain significance Single submitter
- DCDC2B p.Ser283Thr Uncertain significance Single submitter
- DCDC2B p.Ser349Pro Uncertain significance Single submitter
- DCDC2B p.Thr298Ala Uncertain significance Single submitter
- DCDC2B p.Thr310Pro Uncertain significance Single submitter
- DCDC2B p.Tyr289His Uncertain significance Single submitter
- DCDC2B p.Val140Ile Uncertain significance Single submitter
- DCDC2B p.Val159Leu Uncertain significance Single submitter
Predictors split 26
The independent predictors disagree with each other — read with care.
- DCDC2B p.Ala69Thr Uncertain significance Single submitter
- DCDC2B p.Arg112Cys Uncertain significance Single submitter
- DCDC2B p.Arg15Gln Uncertain significance Single submitter
- DCDC2B p.Arg15Trp Uncertain significance Single submitter
- DCDC2B p.Arg31Cys Uncertain significance Single submitter
- DCDC2B p.Arg31His Uncertain significance Single submitter
- DCDC2B p.Arg32Cys Uncertain significance Single submitter
- DCDC2B p.Arg54Cys Uncertain significance Single submitter
- DCDC2B p.Arg74Ile Uncertain significance Single submitter
- DCDC2B p.Asp138Asn Uncertain significance Single submitter
- DCDC2B p.Asp70Gly Uncertain significance Single submitter
- DCDC2B p.Gln30Arg Uncertain significance Single submitter
- DCDC2B p.Glu42Asp Uncertain significance Single submitter
- DCDC2B p.Glu42Lys Uncertain significance Single submitter
- DCDC2B p.Gly17Arg Uncertain significance Single submitter
- DCDC2B p.Gly201Arg Uncertain significance Single submitter
- DCDC2B p.His61Tyr Uncertain significance Single submitter
- DCDC2B p.Leu177Phe Uncertain significance Single submitter
- DCDC2B p.Leu177Val Uncertain significance Single submitter
- DCDC2B p.Leu214Pro Uncertain significance Single submitter
- DCDC2B p.Leu328Met Uncertain significance Single submitter
- DCDC2B p.Lys206Arg Benign Single submitter
- DCDC2B p.Met36Thr Uncertain significance Single submitter
- DCDC2B p.Pro216Thr Uncertain significance Single submitter
- DCDC2B p.Ser171Asn Uncertain significance Single submitter
- DCDC2B p.Val47Met Uncertain significance Single submitter
All DCDC2B variants
Benign 1
- p.Lys206Arg Single submitter ⚠
Likely benign 1
- p.Arg256Gln Single submitter
Uncertain significance 54
- p.Ala125Pro Single submitter ⚠
- p.Ala187Gly Single submitter ⚠
- p.Ala239Ser Single submitter ⚠
- p.Ala291Thr Single submitter ⚠
- p.Ala346Val Single submitter ⚠
- p.Ala55Ser Single submitter ⚠
- p.Ala55Val Single submitter ⚠
- p.Ala69Glu Single submitter ⚠
- p.Ala69Thr Single submitter ⚠
- p.Arg112Cys Single submitter ⚠
- p.Arg15Gln Single submitter ⚠
- p.Arg15Trp Single submitter ⚠
- p.Arg31Cys Single submitter ⚠
- p.Arg31His Single submitter ⚠
- p.Arg32Cys Single submitter ⚠
- p.Arg54Cys Single submitter ⚠
- p.Arg74Ile Single submitter ⚠
- p.Asp138Asn Single submitter ⚠
- p.Asp207Asn Single submitter ⚠
- p.Asp70Gly Single submitter ⚠
- p.Asp97Gly Single submitter ⚠
- p.Cys115Tyr Single submitter ⚠
- p.Gln30Arg Single submitter ⚠
- p.Glu204Val Single submitter ⚠
- p.Glu42Asp Single submitter ⚠
- p.Glu42Lys Single submitter ⚠
- p.Gly126Asp Single submitter ⚠
- p.Gly137Ala Single submitter ⚠
- p.Gly17Arg Single submitter ⚠
- p.Gly17Glu Single submitter ⚠
- p.Gly201Arg Single submitter ⚠
- p.Gly223Asp Single submitter ⚠
- p.His61Tyr Single submitter ⚠
- p.His93Arg Single submitter ⚠
- p.Ile119Thr Single submitter ⚠
- p.Leu162Pro Single submitter ⚠
- p.Leu177Phe Single submitter ⚠
- p.Leu177Val Single submitter ⚠
- p.Leu183Val Single submitter ⚠
- p.Leu214Pro Single submitter ⚠
- p.Leu328Met Single submitter ⚠
- p.Met36Thr Single submitter ⚠
- p.Phe144Cys Single submitter ⚠
- p.Pro216Thr Single submitter ⚠
- p.Ser171Asn Single submitter ⚠
- p.Ser230Leu Single submitter ⚠
- p.Ser283Thr Single submitter ⚠
- p.Ser349Pro Single submitter ⚠
- p.Thr298Ala Single submitter ⚠
- p.Thr310Pro Single submitter ⚠
- p.Tyr289His Single submitter ⚠
- p.Val140Ile Single submitter ⚠
- p.Val159Leu Single submitter ⚠
- p.Val47Met Single submitter ⚠