DCK — 17 ClinVar variants

All ClinVar germline DCK variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 16 flagged for review →

1 Likely benign · 16 Uncertain significance

Full DCK gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 16

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 10

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 6

The independent predictors disagree with each other — read with care.

All DCK variants

Likely benign 1

p.Tyr142= Single submitter

Uncertain significance 16

p.Ala2Val Single submitter ⚠
p.Asn39Ser Single submitter ⚠
p.Asn60Ser Single submitter ⚠
p.Asp160Asn Single submitter ⚠
p.Asp160Val Single submitter ⚠
p.Ile154Val Single submitter ⚠
p.Ile189Leu Single submitter ⚠
p.Ile233Val Single submitter ⚠
p.Leu116Ile Single submitter ⚠
p.Leu249Gln Single submitter ⚠
p.Leu260Trp Single submitter ⚠
p.Lys76Arg Single submitter ⚠
p.Phe94Ser Single submitter ⚠
p.Phe96Val Single submitter ⚠
p.Pro4Leu Single submitter ⚠
p.Trp152Arg Single submitter ⚠