DCLK1 — 29 ClinVar variants
All ClinVar germline DCLK1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 24 flagged for review →
2 Benign · 27 Uncertain significance
Full DCLK1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 24
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 18
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DCLK1 p.Asp618Asn Uncertain significance Multiple submitters
- DCLK1 p.Ala167Val Uncertain significance Single submitter
- DCLK1 p.Ala357Thr Uncertain significance Single submitter
- DCLK1 p.Ala488Thr Uncertain significance Single submitter
- DCLK1 p.Arg342Gln Uncertain significance Single submitter
- DCLK1 p.Asn655Tyr Uncertain significance Single submitter
- DCLK1 p.Gln658Glu Uncertain significance Single submitter
- DCLK1 p.Gly563Arg Uncertain significance Single submitter
- DCLK1 p.Leu544Gln Uncertain significance Single submitter
- DCLK1 p.Met627Thr Uncertain significance Single submitter
- DCLK1 p.Pro675Ser Uncertain significance Single submitter
- DCLK1 p.Ser165Pro Uncertain significance Single submitter
- DCLK1 p.Ser172Asn Uncertain significance Single submitter
- DCLK1 p.Ser22Ile Uncertain significance Single submitter
- DCLK1 p.Thr236Met Uncertain significance Single submitter
- DCLK1 p.Thr324Ala Uncertain significance Single submitter
- DCLK1 p.Thr49Ser Uncertain significance Single submitter
- DCLK1 p.Val163Ala Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- DCLK1 p.Arg277Gln Uncertain significance Single submitter
- DCLK1 p.Asn98Lys Uncertain significance Single submitter
- DCLK1 p.Asp16Asn Uncertain significance Single submitter
- DCLK1 p.Ser32Ile Uncertain significance Single submitter
- DCLK1 p.Thr110Asn Uncertain significance Single submitter
- DCLK1 p.Val154Ile Uncertain significance Single submitter
All DCLK1 variants
Uncertain significance 27
- p.Asp618Asn Multiple submitters ⚠
- c.2058+5084G>C Single submitter
- p.Ala167Val Single submitter ⚠
- p.Ala357Thr Single submitter ⚠
- p.Ala488Thr Single submitter ⚠
- p.Arg277Gln Single submitter ⚠
- p.Arg304Cys Single submitter
- p.Arg342Gln Single submitter ⚠
- p.Asn655Tyr Single submitter ⚠
- p.Asn98Lys Single submitter ⚠
- p.Asp16Asn Single submitter ⚠
- p.Gln594Glu Single submitter
- p.Gln658Glu Single submitter ⚠
- p.Gly563Arg Single submitter ⚠
- p.Leu544Gln Single submitter ⚠
- p.Met627Thr Single submitter ⚠
- p.Pro675Ser Single submitter ⚠
- p.Ser165Pro Single submitter ⚠
- p.Ser172Asn Single submitter ⚠
- p.Ser22Ile Single submitter ⚠
- p.Ser32Ile Single submitter ⚠
- p.Thr110Asn Single submitter ⚠
- p.Thr236Met Single submitter ⚠
- p.Thr324Ala Single submitter ⚠
- p.Thr49Ser Single submitter ⚠
- p.Val154Ile Single submitter ⚠
- p.Val163Ala Single submitter ⚠