DCLK2 — 84 ClinVar variants
All ClinVar germline DCLK2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 77 flagged for review →
6 Likely benign · 78 Uncertain significance
Full DCLK2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 77
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 44
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DCLK2 p.Ala27Gly Uncertain significance Single submitter
- DCLK2 p.Ala421Ser Uncertain significance Single submitter
- DCLK2 p.Ala676Val Uncertain significance Single submitter
- DCLK2 p.Arg153Leu Uncertain significance Single submitter
- DCLK2 p.Arg15Pro Uncertain significance Single submitter
- DCLK2 p.Arg372His Uncertain significance Single submitter
- DCLK2 p.Arg372Pro Uncertain significance Single submitter
- DCLK2 p.Arg5Lys Uncertain significance Single submitter
- DCLK2 p.Arg757Gln Uncertain significance Single submitter
- DCLK2 p.Arg765Gln Uncertain significance Single submitter
- DCLK2 p.Asn501Ser Uncertain significance Single submitter
- DCLK2 p.Asn595Lys Uncertain significance Single submitter
- DCLK2 p.Asp100Glu Uncertain significance Single submitter
- DCLK2 p.Asp618Val Uncertain significance Single submitter
- DCLK2 p.Cys269Arg Uncertain significance Single submitter
- DCLK2 p.Gln598Arg Uncertain significance Single submitter
- DCLK2 p.Gln657Arg Uncertain significance Single submitter
- DCLK2 p.Glu727Val Uncertain significance Single submitter
- DCLK2 p.Gly240Arg Uncertain significance Single submitter
- DCLK2 p.Gly32Arg Uncertain significance Single submitter
- DCLK2 p.Gly366Ser Uncertain significance Single submitter
- DCLK2 p.Gly546Arg Uncertain significance Single submitter
- DCLK2 p.Gly569Asp Uncertain significance Single submitter
- DCLK2 p.Gly732Glu Uncertain significance Single submitter
- DCLK2 p.Gly754Val Uncertain significance Single submitter
- DCLK2 p.Gly755Ser Uncertain significance Single submitter
- DCLK2 p.His648Arg Uncertain significance Single submitter
- DCLK2 p.Ile620Val Uncertain significance Single submitter
- DCLK2 p.Ile690Val Uncertain significance Single submitter
- DCLK2 p.Met454Leu Uncertain significance Single submitter
- DCLK2 p.Phe266Cys Uncertain significance Single submitter
- DCLK2 p.Phe348Leu Uncertain significance Single submitter
- DCLK2 p.Phe673Cys Uncertain significance Single submitter
- DCLK2 p.Phe99Leu Uncertain significance Single submitter
- DCLK2 p.Pro117Leu Uncertain significance Single submitter
- DCLK2 p.Pro722Leu Uncertain significance Single submitter
- DCLK2 p.Ser174Pro Uncertain significance Single submitter
- DCLK2 p.Ser181Pro Uncertain significance Single submitter
- DCLK2 p.Ser361Pro Uncertain significance Single submitter
- DCLK2 p.Ser415Ala Uncertain significance Single submitter
- DCLK2 p.Ser724Leu Uncertain significance Single submitter
- DCLK2 p.Ser92Pro Uncertain significance Single submitter
- DCLK2 p.Val206Leu Uncertain significance Single submitter
- DCLK2 p.Val735Ile Uncertain significance Single submitter
Predictors split 33
The independent predictors disagree with each other — read with care.
- DCLK2 p.Ala176Val Uncertain significance Single submitter
- DCLK2 p.Ala178Val Uncertain significance Single submitter
- DCLK2 p.Ala49Glu Uncertain significance Single submitter
- DCLK2 p.Arg130Gln Uncertain significance Single submitter
- DCLK2 p.Arg314His Uncertain significance Single submitter
- DCLK2 p.Arg314Ser Uncertain significance Single submitter
- DCLK2 p.Arg762Cys Uncertain significance Single submitter
- DCLK2 p.Arg762His Uncertain significance Single submitter
- DCLK2 p.Arg763Cys Uncertain significance Single submitter
- DCLK2 p.Arg82His Uncertain significance Single submitter
- DCLK2 p.Asn451Ser Uncertain significance Single submitter
- DCLK2 p.Asp136Glu Uncertain significance Single submitter
- DCLK2 p.Gln278Arg Uncertain significance Single submitter
- DCLK2 p.Glu410Gln Uncertain significance Single submitter
- DCLK2 p.Ile412Met Likely benign Single submitter
- DCLK2 p.Ile511Val Uncertain significance Single submitter
- DCLK2 p.Leu44Arg Uncertain significance Single submitter
- DCLK2 p.Leu606Val Uncertain significance Single submitter
- DCLK2 p.Lys531Gln Uncertain significance Single submitter
- DCLK2 p.Met454Val Uncertain significance Single submitter
- DCLK2 p.Pro46Thr Uncertain significance Single submitter
- DCLK2 p.Pro720Leu Uncertain significance Single submitter
- DCLK2 p.Pro736Leu Likely benign Single submitter
- DCLK2 p.Ser296Cys Uncertain significance Single submitter
- DCLK2 p.Ser330Pro Uncertain significance Single submitter
- DCLK2 p.Ser341Phe Uncertain significance Single submitter
- DCLK2 p.Ser34Cys Uncertain significance Single submitter
- DCLK2 p.Ser375Arg Uncertain significance Single submitter
- DCLK2 p.Ser484Leu Uncertain significance Single submitter
- DCLK2 p.Tyr526Phe Uncertain significance Single submitter
- DCLK2 p.Val242Ile Uncertain significance Single submitter
- DCLK2 p.Val290Ile Uncertain significance Single submitter
- DCLK2 p.Val544Ile Uncertain significance Single submitter
All DCLK2 variants
Likely benign 6
- c.961+967A>G Single submitter
- p.Glu434= Single submitter
- p.Ile412Met Single submitter ⚠
- p.Pro21= Single submitter
- p.Pro731= Single submitter
- p.Pro736Leu Single submitter ⚠
Uncertain significance 78
- c.961+930C>T Single submitter
- c.961+955A>G Single submitter
- c.961+963G>A Single submitter
- p.Ala176Val Single submitter ⚠
- p.Ala178Val Single submitter ⚠
- p.Ala27Gly Single submitter ⚠
- p.Ala421Ser Single submitter ⚠
- p.Ala49Glu Single submitter ⚠
- p.Ala676Val Single submitter ⚠
- p.Arg130Gln Single submitter ⚠
- p.Arg153Leu Single submitter ⚠
- p.Arg15Pro Single submitter ⚠
- p.Arg314His Single submitter ⚠
- p.Arg314Ser Single submitter ⚠
- p.Arg372His Single submitter ⚠
- p.Arg372Pro Single submitter ⚠
- p.Arg5Lys Single submitter ⚠
- p.Arg757Gln Single submitter ⚠
- p.Arg762Cys Single submitter ⚠
- p.Arg762His Single submitter ⚠
- p.Arg763Cys Single submitter ⚠
- p.Arg765Gln Single submitter ⚠
- p.Arg82His Single submitter ⚠
- p.Asn451Ser Single submitter ⚠
- p.Asn501Ser Single submitter ⚠
- p.Asn595Lys Single submitter ⚠
- p.Asp100Glu Single submitter ⚠
- p.Asp136Glu Single submitter ⚠
- p.Asp618Val Single submitter ⚠
- p.Cys269Arg Single submitter ⚠
- p.Gln278Arg Single submitter ⚠
- p.Gln598Arg Single submitter ⚠
- p.Gln657Arg Single submitter ⚠
- p.Glu410Gln Single submitter ⚠
- p.Glu727Val Single submitter ⚠
- p.Gly240Arg Single submitter ⚠
- p.Gly32Arg Single submitter ⚠
- p.Gly366Ser Single submitter ⚠
- p.Gly546Arg Single submitter ⚠
- p.Gly569Asp Single submitter ⚠
- p.Gly732Glu Single submitter ⚠
- p.Gly754Val Single submitter ⚠
- p.Gly755Ser Single submitter ⚠
- p.His648Arg Single submitter ⚠
- p.Ile511Val Single submitter ⚠
- p.Ile620Val Single submitter ⚠
- p.Ile690Val Single submitter ⚠
- p.Leu44Arg Single submitter ⚠
- p.Leu606Val Single submitter ⚠
- p.Lys531Gln Single submitter ⚠
- p.Met454Leu Single submitter ⚠
- p.Met454Val Single submitter ⚠
- p.Phe266Cys Single submitter ⚠
- p.Phe348Leu Single submitter ⚠
- p.Phe673Cys Single submitter ⚠
- p.Phe99Leu Single submitter ⚠
- p.Pro117Leu Single submitter ⚠
- p.Pro46Thr Single submitter ⚠
- p.Pro720Leu Single submitter ⚠
- p.Pro722Leu Single submitter ⚠
- p.Ser174Pro Single submitter ⚠
- p.Ser181Pro Single submitter ⚠
- p.Ser296Cys Single submitter ⚠
- p.Ser330Pro Single submitter ⚠
- p.Ser341Phe Single submitter ⚠
- p.Ser34Cys Single submitter ⚠
- p.Ser361Pro Single submitter ⚠
- p.Ser375Arg Single submitter ⚠
- p.Ser415Ala Single submitter ⚠
- p.Ser484Leu Single submitter ⚠
- p.Ser724Leu Single submitter ⚠
- p.Ser92Pro Single submitter ⚠
- p.Tyr526Phe Single submitter ⚠
- p.Val206Leu Single submitter ⚠
- p.Val242Ile Single submitter ⚠
- p.Val290Ile Single submitter ⚠
- p.Val544Ile Single submitter ⚠
- p.Val735Ile Single submitter ⚠