DCLK3 — 89 ClinVar variants
All ClinVar germline DCLK3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 86 flagged for review →
3 Likely benign · 86 Uncertain significance
Full DCLK3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 86
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 65
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DCLK3 p.Ala198Val Uncertain significance Single submitter
- DCLK3 p.Ala361Glu Uncertain significance Single submitter
- DCLK3 p.Ala405Thr Uncertain significance Single submitter
- DCLK3 p.Ala405Val Uncertain significance Single submitter
- DCLK3 p.Ala451Pro Uncertain significance Single submitter
- DCLK3 p.Ala755Thr Uncertain significance Single submitter
- DCLK3 p.Arg353Thr Uncertain significance Single submitter
- DCLK3 p.Arg385Lys Uncertain significance Single submitter
- DCLK3 p.Arg505Gln Uncertain significance Single submitter
- DCLK3 p.Arg645Gln Uncertain significance Single submitter
- DCLK3 p.Arg645Trp Uncertain significance Single submitter
- DCLK3 p.Asn535His Uncertain significance Single submitter
- DCLK3 p.Asp668Gly Uncertain significance Single submitter
- DCLK3 p.Cys223Ser Uncertain significance Single submitter
- DCLK3 p.Cys238Gly Uncertain significance Single submitter
- DCLK3 p.Gln486Arg Uncertain significance Single submitter
- DCLK3 p.Gln486Pro Uncertain significance Single submitter
- DCLK3 p.Gln815Pro Uncertain significance Single submitter
- DCLK3 p.Glu250Lys Uncertain significance Single submitter
- DCLK3 p.Glu251Asp Uncertain significance Single submitter
- DCLK3 p.Glu291Lys Uncertain significance Single submitter
- DCLK3 p.Glu299Gly Uncertain significance Single submitter
- DCLK3 p.Glu417Gly Uncertain significance Single submitter
- DCLK3 p.Glu467Ala Uncertain significance Single submitter
- DCLK3 p.Glu491Lys Uncertain significance Single submitter
- DCLK3 p.Gly303Arg Uncertain significance Single submitter
- DCLK3 p.Gly442Val Uncertain significance Single submitter
- DCLK3 p.Gly443Ser Uncertain significance Single submitter
- DCLK3 p.Gly508Asp Uncertain significance Single submitter
- DCLK3 p.His287Asn Uncertain significance Single submitter
- DCLK3 p.His372Pro Uncertain significance Single submitter
- DCLK3 p.His404Gln Uncertain significance Single submitter
- DCLK3 p.His441Leu Uncertain significance Single submitter
- DCLK3 p.His774Asn Uncertain significance Single submitter
- DCLK3 p.His804Tyr Uncertain significance Single submitter
- DCLK3 p.Ile599Val Uncertain significance Single submitter
- DCLK3 p.Ile714Thr Uncertain significance Single submitter
- DCLK3 p.Leu419His Uncertain significance Single submitter
- DCLK3 p.Leu490Pro Uncertain significance Single submitter
- DCLK3 p.Lys230Gln Uncertain significance Single submitter
- DCLK3 p.Lys276Arg Uncertain significance Single submitter
- DCLK3 p.Lys337Thr Uncertain significance Single submitter
- DCLK3 p.Lys495Glu Uncertain significance Single submitter
- DCLK3 p.Lys617Arg Uncertain significance Single submitter
- DCLK3 p.Met340Ile Uncertain significance Single submitter
- DCLK3 p.Met480Val Uncertain significance Single submitter
- DCLK3 p.Met628Val Uncertain significance Single submitter
- DCLK3 p.Pro273Leu Uncertain significance Single submitter
- DCLK3 p.Pro273Ser Uncertain significance Single submitter
- DCLK3 p.Pro277Ser Uncertain significance Single submitter
- DCLK3 p.Pro278Leu Uncertain significance Single submitter
- DCLK3 p.Pro376Ser Uncertain significance Single submitter
- DCLK3 p.Pro386Ser Uncertain significance Single submitter
- DCLK3 p.Pro398Ser Uncertain significance Single submitter
- DCLK3 p.Pro435Ala Uncertain significance Single submitter
- DCLK3 p.Pro746Ala Uncertain significance Single submitter
- DCLK3 p.Ser275Arg Uncertain significance Single submitter
- DCLK3 p.Ser320Arg Uncertain significance Single submitter
- DCLK3 p.Ser374Gly Uncertain significance Single submitter
- DCLK3 p.Ser559Thr Uncertain significance Single submitter
- DCLK3 p.Thr380Ala Uncertain significance Single submitter
- DCLK3 p.Thr685Ile Uncertain significance Single submitter
- DCLK3 p.Val296Leu Uncertain significance Single submitter
- DCLK3 p.Val676Leu Uncertain significance Single submitter
- DCLK3 p.Val797Leu Uncertain significance Single submitter
Predictors split 21
The independent predictors disagree with each other — read with care.
- DCLK3 p.Arg193Trp Uncertain significance Single submitter
- DCLK3 p.Arg323His Uncertain significance Single submitter
- DCLK3 p.Arg457Cys Uncertain significance Single submitter
- DCLK3 p.Arg509Gln Uncertain significance Single submitter
- DCLK3 p.Arg512Gln Uncertain significance Single submitter
- DCLK3 p.Arg512Trp Uncertain significance Single submitter
- DCLK3 p.Arg656Gln Uncertain significance Single submitter
- DCLK3 p.Arg761Gln Uncertain significance Single submitter
- DCLK3 p.Arg806Trp Uncertain significance Single submitter
- DCLK3 p.Asn657Asp Uncertain significance Single submitter
- DCLK3 p.Asp753Tyr Uncertain significance Single submitter
- DCLK3 p.Glu614Gln Uncertain significance Single submitter
- DCLK3 p.His587Tyr Uncertain significance Single submitter
- DCLK3 p.Ile735Phe Uncertain significance Single submitter
- DCLK3 p.Leu317Val Uncertain significance Single submitter
- DCLK3 p.Met626Val Uncertain significance Single submitter
- DCLK3 p.Ser387Asn Uncertain significance Single submitter
- DCLK3 p.Ser475Cys Uncertain significance Single submitter
- DCLK3 p.Thr349Ile Uncertain significance Single submitter
- DCLK3 p.Val676Met Uncertain significance Single submitter
- DCLK3 p.Val816Ile Uncertain significance Single submitter
All DCLK3 variants
Likely benign 3
- p.Ala258Val Single submitter
- p.Arg193Gln Single submitter
- p.Met242Ile Single submitter
Uncertain significance 86
- p.Ala198Val Single submitter ⚠
- p.Ala361Glu Single submitter ⚠
- p.Ala405Thr Single submitter ⚠
- p.Ala405Val Single submitter ⚠
- p.Ala451Pro Single submitter ⚠
- p.Ala755Thr Single submitter ⚠
- p.Arg193Trp Single submitter ⚠
- p.Arg323His Single submitter ⚠
- p.Arg353Thr Single submitter ⚠
- p.Arg385Lys Single submitter ⚠
- p.Arg457Cys Single submitter ⚠
- p.Arg505Gln Single submitter ⚠
- p.Arg509Gln Single submitter ⚠
- p.Arg512Gln Single submitter ⚠
- p.Arg512Trp Single submitter ⚠
- p.Arg645Gln Single submitter ⚠
- p.Arg645Trp Single submitter ⚠
- p.Arg656Gln Single submitter ⚠
- p.Arg761Gln Single submitter ⚠
- p.Arg806Trp Single submitter ⚠
- p.Asn535His Single submitter ⚠
- p.Asn657Asp Single submitter ⚠
- p.Asp668Gly Single submitter ⚠
- p.Asp753Tyr Single submitter ⚠
- p.Cys223Ser Single submitter ⚠
- p.Cys238Gly Single submitter ⚠
- p.Gln486Arg Single submitter ⚠
- p.Gln486Pro Single submitter ⚠
- p.Gln815Pro Single submitter ⚠
- p.Glu250Lys Single submitter ⚠
- p.Glu251Asp Single submitter ⚠
- p.Glu291Lys Single submitter ⚠
- p.Glu299Gly Single submitter ⚠
- p.Glu417Gly Single submitter ⚠
- p.Glu467Ala Single submitter ⚠
- p.Glu491Lys Single submitter ⚠
- p.Glu614Gln Single submitter ⚠
- p.Gly303Arg Single submitter ⚠
- p.Gly442Val Single submitter ⚠
- p.Gly443Ser Single submitter ⚠
- p.Gly508Asp Single submitter ⚠
- p.His287Asn Single submitter ⚠
- p.His372Pro Single submitter ⚠
- p.His404Gln Single submitter ⚠
- p.His441Leu Single submitter ⚠
- p.His587Tyr Single submitter ⚠
- p.His774Asn Single submitter ⚠
- p.His804Tyr Single submitter ⚠
- p.Ile599Val Single submitter ⚠
- p.Ile714Thr Single submitter ⚠
- p.Ile735Phe Single submitter ⚠
- p.Leu317Val Single submitter ⚠
- p.Leu419His Single submitter ⚠
- p.Leu490Pro Single submitter ⚠
- p.Lys230Gln Single submitter ⚠
- p.Lys276Arg Single submitter ⚠
- p.Lys337Thr Single submitter ⚠
- p.Lys495Glu Single submitter ⚠
- p.Lys617Arg Single submitter ⚠
- p.Met340Ile Single submitter ⚠
- p.Met480Val Single submitter ⚠
- p.Met626Val Single submitter ⚠
- p.Met628Val Single submitter ⚠
- p.Pro273Leu Single submitter ⚠
- p.Pro273Ser Single submitter ⚠
- p.Pro277Ser Single submitter ⚠
- p.Pro278Leu Single submitter ⚠
- p.Pro376Ser Single submitter ⚠
- p.Pro386Ser Single submitter ⚠
- p.Pro398Ser Single submitter ⚠
- p.Pro435Ala Single submitter ⚠
- p.Pro746Ala Single submitter ⚠
- p.Ser275Arg Single submitter ⚠
- p.Ser320Arg Single submitter ⚠
- p.Ser374Gly Single submitter ⚠
- p.Ser387Asn Single submitter ⚠
- p.Ser475Cys Single submitter ⚠
- p.Ser559Thr Single submitter ⚠
- p.Thr349Ile Single submitter ⚠
- p.Thr380Ala Single submitter ⚠
- p.Thr685Ile Single submitter ⚠
- p.Val296Leu Single submitter ⚠
- p.Val676Leu Single submitter ⚠
- p.Val676Met Single submitter ⚠
- p.Val797Leu Single submitter ⚠
- p.Val816Ile Single submitter ⚠