DCP1B — 101 ClinVar variants
All ClinVar germline DCP1B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 89 flagged for review →
3 Benign · 9 Likely benign · 89 Uncertain significance
Full DCP1B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 89
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 66
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DCP1B p.Ala302Thr Uncertain significance Single submitter
- DCP1B p.Ala387Val Uncertain significance Single submitter
- DCP1B p.Ala475Thr Uncertain significance Single submitter
- DCP1B p.Ala520Val Uncertain significance Single submitter
- DCP1B p.Ala612Thr Uncertain significance Single submitter
- DCP1B p.Arg314Gln Uncertain significance Single submitter
- DCP1B p.Arg344Cys Uncertain significance Single submitter
- DCP1B p.Arg470Gln Uncertain significance Single submitter
- DCP1B p.Arg514His Uncertain significance Single submitter
- DCP1B p.Asn339Ile Uncertain significance Single submitter
- DCP1B p.Asn339Thr Uncertain significance Single submitter
- DCP1B p.Asp160His Uncertain significance Single submitter
- DCP1B p.Asp220Val Uncertain significance Single submitter
- DCP1B p.Cys178Gly Uncertain significance Single submitter
- DCP1B p.Gln140Glu Uncertain significance Single submitter
- DCP1B p.Gln209Arg Uncertain significance Single submitter
- DCP1B p.Gln289Arg Uncertain significance Single submitter
- DCP1B p.Gln353Lys Uncertain significance Single submitter
- DCP1B p.Gln360His Uncertain significance Single submitter
- DCP1B p.Gln402His Uncertain significance Single submitter
- DCP1B p.Gln502Glu Uncertain significance Single submitter
- DCP1B p.Glu222Lys Uncertain significance Single submitter
- DCP1B p.Gly438Asp Uncertain significance Single submitter
- DCP1B p.Gly485Ala Uncertain significance Single submitter
- DCP1B p.Gly485Glu Uncertain significance Single submitter
- DCP1B p.Gly544Ser Uncertain significance Single submitter
- DCP1B p.Gly71Glu Uncertain significance Single submitter
- DCP1B p.Gly71Val Uncertain significance Single submitter
- DCP1B p.His282Gln Uncertain significance Single submitter
- DCP1B p.His282Tyr Uncertain significance Single submitter
- DCP1B p.His338Pro Uncertain significance Single submitter
- DCP1B p.His422Leu Uncertain significance Single submitter
- DCP1B p.His45Leu Uncertain significance Single submitter
- DCP1B p.Ile166Phe Uncertain significance Single submitter
- DCP1B p.Leu304Phe Uncertain significance Single submitter
- DCP1B p.Leu382Val Uncertain significance Single submitter
- DCP1B p.Lys137Glu Uncertain significance Single submitter
- DCP1B p.Lys237Arg Uncertain significance Single submitter
- DCP1B p.Lys476Glu Uncertain significance Single submitter
- DCP1B p.Met298Ile Uncertain significance Single submitter
- DCP1B p.Met528Val Uncertain significance Single submitter
- DCP1B p.Met617Lys Uncertain significance Single submitter
- DCP1B p.Pro148Ser Uncertain significance Single submitter
- DCP1B p.Pro181Arg Uncertain significance Single submitter
- DCP1B p.Pro213Ser Uncertain significance Single submitter
- DCP1B p.Pro247Gln Uncertain significance Single submitter
- DCP1B p.Pro247Leu Uncertain significance Single submitter
- DCP1B p.Pro26Leu Uncertain significance Single submitter
- DCP1B p.Pro371Ser Uncertain significance Single submitter
- DCP1B p.Pro393Ser Uncertain significance Single submitter
- DCP1B p.Pro471Thr Uncertain significance Single submitter
- DCP1B p.Pro521Ser Uncertain significance Single submitter
- DCP1B p.Ser17Arg Uncertain significance Single submitter
- DCP1B p.Ser205Arg Uncertain significance Single submitter
- DCP1B p.Ser543Thr Uncertain significance Single submitter
- DCP1B p.Thr362Asn Uncertain significance Single submitter
- DCP1B p.Thr42Ile Uncertain significance Single submitter
- DCP1B p.Thr486Ile Uncertain significance Single submitter
- DCP1B p.Thr500Ala Uncertain significance Single submitter
- DCP1B p.Thr534Pro Uncertain significance Single submitter
- DCP1B p.Thr609Ser Uncertain significance Single submitter
- DCP1B p.Tyr115Cys Uncertain significance Single submitter
- DCP1B p.Tyr27Cys Uncertain significance Single submitter
- DCP1B p.Tyr407Asp Uncertain significance Single submitter
- DCP1B p.Val346Ala Uncertain significance Single submitter
- DCP1B p.Val536Ile Uncertain significance Single submitter
Predictors split 23
The independent predictors disagree with each other — read with care.
- DCP1B p.Ala3Pro Uncertain significance Single submitter
- DCP1B p.Ala585Thr Uncertain significance Single submitter
- DCP1B p.Arg470Trp Uncertain significance Single submitter
- DCP1B p.Arg514Cys Uncertain significance Single submitter
- DCP1B p.Asn598Thr Uncertain significance Single submitter
- DCP1B p.Gln460Arg Uncertain significance Single submitter
- DCP1B p.Glu171Lys Uncertain significance Single submitter
- DCP1B p.Ile190Met Uncertain significance Single submitter
- DCP1B p.Leu290Phe Uncertain significance Single submitter
- DCP1B p.Leu456Phe Uncertain significance Single submitter
- DCP1B p.Pro569Leu Uncertain significance Single submitter
- DCP1B p.Ser385Arg Uncertain significance Single submitter
- DCP1B p.Ser484Phe Uncertain significance Single submitter
- DCP1B p.Ser492Phe Uncertain significance Single submitter
- DCP1B p.Ser575Asn Uncertain significance Single submitter
- DCP1B p.Thr243Ile Uncertain significance Single submitter
- DCP1B p.Thr329Ile Uncertain significance Single submitter
- DCP1B p.Thr504Ile Uncertain significance Single submitter
- DCP1B p.Thr63Ile Uncertain significance Single submitter
- DCP1B p.Val159Gly Uncertain significance Single submitter
- DCP1B p.Val202Ala Uncertain significance Single submitter
- DCP1B p.Val391Ile Uncertain significance Single submitter
- DCP1B p.Val571Met Uncertain significance Single submitter
All DCP1B variants
Benign 3
- p.Pro567= Multiple submitters
- p.Ser301Thr Multiple submitters
- p.Arg384His Single submitter
Likely benign 9
- c.319+59A>G Single submitter
- p.Ala481Thr Single submitter
- p.Arg211His Single submitter
- p.Gln140His Single submitter
- p.Gln432Pro Single submitter
- p.Ile31= Single submitter
- p.Pro98= Single submitter
- p.Ser543= Single submitter
- p.Thr142Ala Single submitter
Uncertain significance 89
- p.Ala302Thr Single submitter ⚠
- p.Ala387Val Single submitter ⚠
- p.Ala3Pro Single submitter ⚠
- p.Ala475Thr Single submitter ⚠
- p.Ala520Val Single submitter ⚠
- p.Ala585Thr Single submitter ⚠
- p.Ala612Thr Single submitter ⚠
- p.Arg314Gln Single submitter ⚠
- p.Arg344Cys Single submitter ⚠
- p.Arg470Gln Single submitter ⚠
- p.Arg470Trp Single submitter ⚠
- p.Arg514Cys Single submitter ⚠
- p.Arg514His Single submitter ⚠
- p.Asn339Ile Single submitter ⚠
- p.Asn339Thr Single submitter ⚠
- p.Asn598Thr Single submitter ⚠
- p.Asp160His Single submitter ⚠
- p.Asp220Val Single submitter ⚠
- p.Cys178Gly Single submitter ⚠
- p.Gln140Glu Single submitter ⚠
- p.Gln209Arg Single submitter ⚠
- p.Gln289Arg Single submitter ⚠
- p.Gln353Lys Single submitter ⚠
- p.Gln360His Single submitter ⚠
- p.Gln402His Single submitter ⚠
- p.Gln460Arg Single submitter ⚠
- p.Gln502Glu Single submitter ⚠
- p.Glu171Lys Single submitter ⚠
- p.Glu222Lys Single submitter ⚠
- p.Gly438Asp Single submitter ⚠
- p.Gly485Ala Single submitter ⚠
- p.Gly485Glu Single submitter ⚠
- p.Gly544Ser Single submitter ⚠
- p.Gly71Glu Single submitter ⚠
- p.Gly71Val Single submitter ⚠
- p.His282Gln Single submitter ⚠
- p.His282Tyr Single submitter ⚠
- p.His338Pro Single submitter ⚠
- p.His422Leu Single submitter ⚠
- p.His45Leu Single submitter ⚠
- p.Ile166Phe Single submitter ⚠
- p.Ile190Met Single submitter ⚠
- p.Leu290Phe Single submitter ⚠
- p.Leu304Phe Single submitter ⚠
- p.Leu382Val Single submitter ⚠
- p.Leu456Phe Single submitter ⚠
- p.Lys137Glu Single submitter ⚠
- p.Lys237Arg Single submitter ⚠
- p.Lys476Glu Single submitter ⚠
- p.Met298Ile Single submitter ⚠
- p.Met528Val Single submitter ⚠
- p.Met617Lys Single submitter ⚠
- p.Pro148Ser Single submitter ⚠
- p.Pro181Arg Single submitter ⚠
- p.Pro213Ser Single submitter ⚠
- p.Pro247Gln Single submitter ⚠
- p.Pro247Leu Single submitter ⚠
- p.Pro26Leu Single submitter ⚠
- p.Pro371Ser Single submitter ⚠
- p.Pro393Ser Single submitter ⚠
- p.Pro471Thr Single submitter ⚠
- p.Pro521Ser Single submitter ⚠
- p.Pro569Leu Single submitter ⚠
- p.Ser17Arg Single submitter ⚠
- p.Ser205Arg Single submitter ⚠
- p.Ser385Arg Single submitter ⚠
- p.Ser484Phe Single submitter ⚠
- p.Ser492Phe Single submitter ⚠
- p.Ser543Thr Single submitter ⚠
- p.Ser575Asn Single submitter ⚠
- p.Thr243Ile Single submitter ⚠
- p.Thr329Ile Single submitter ⚠
- p.Thr362Asn Single submitter ⚠
- p.Thr42Ile Single submitter ⚠
- p.Thr486Ile Single submitter ⚠
- p.Thr500Ala Single submitter ⚠
- p.Thr504Ile Single submitter ⚠
- p.Thr534Pro Single submitter ⚠
- p.Thr609Ser Single submitter ⚠
- p.Thr63Ile Single submitter ⚠
- p.Tyr115Cys Single submitter ⚠
- p.Tyr27Cys Single submitter ⚠
- p.Tyr407Asp Single submitter ⚠
- p.Val159Gly Single submitter ⚠
- p.Val202Ala Single submitter ⚠
- p.Val346Ala Single submitter ⚠
- p.Val391Ile Single submitter ⚠
- p.Val536Ile Single submitter ⚠
- p.Val571Met Single submitter ⚠