DCST2 — 169 ClinVar variants
All ClinVar germline DCST2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 160 flagged for review →
10 Likely benign · 159 Uncertain significance
Full DCST2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 160
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 96
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DCST2 p.Ala135Thr Uncertain significance Single submitter
- DCST2 p.Ala20Thr Uncertain significance Single submitter
- DCST2 p.Ala341Val Uncertain significance Single submitter
- DCST2 p.Ala39Thr Uncertain significance Single submitter
- DCST2 p.Ala597Asp Uncertain significance Single submitter
- DCST2 p.Ala668Val Uncertain significance Single submitter
- DCST2 p.Ala670Val Uncertain significance Single submitter
- DCST2 p.Ala748Thr Uncertain significance Single submitter
- DCST2 p.Ala752Val Uncertain significance Single submitter
- DCST2 p.Arg114His Uncertain significance Single submitter
- DCST2 p.Arg165Trp Uncertain significance Single submitter
- DCST2 p.Arg167His Uncertain significance Single submitter
- DCST2 p.Arg276Gln Uncertain significance Single submitter
- DCST2 p.Arg299Gln Uncertain significance Single submitter
- DCST2 p.Arg318His Uncertain significance Single submitter
- DCST2 p.Arg320Gln Uncertain significance Single submitter
- DCST2 p.Arg388Leu Uncertain significance Single submitter
- DCST2 p.Arg447His Uncertain significance Single submitter
- DCST2 p.Arg486Gln Uncertain significance Single submitter
- DCST2 p.Arg487His Uncertain significance Single submitter
- DCST2 p.Arg491Ser Uncertain significance Single submitter
- DCST2 p.Arg522Trp Uncertain significance Single submitter
- DCST2 p.Asn636Lys Uncertain significance Single submitter
- DCST2 p.Asn636Ser Uncertain significance Single submitter
- DCST2 p.Asp196Asn Uncertain significance Single submitter
- DCST2 p.Asp218Glu Uncertain significance Single submitter
- DCST2 p.Asp650His Uncertain significance Single submitter
- DCST2 p.Asp652Ala Uncertain significance Single submitter
- DCST2 p.Gln441His Uncertain significance Single submitter
- DCST2 p.Gln478Arg Uncertain significance Single submitter
- DCST2 p.Gln537Arg Uncertain significance Single submitter
- DCST2 p.Gln648Glu Uncertain significance Single submitter
- DCST2 p.Gln648His Uncertain significance Single submitter
- DCST2 p.Gln664Lys Uncertain significance Single submitter
- DCST2 p.Gln75Glu Uncertain significance Single submitter
- DCST2 p.Glu310Lys Uncertain significance Single submitter
- DCST2 p.Glu385Lys Uncertain significance Single submitter
- DCST2 p.Glu408Lys Uncertain significance Single submitter
- DCST2 p.Glu538Gln Uncertain significance Single submitter
- DCST2 p.Glu538Lys Uncertain significance Single submitter
- DCST2 p.Gly13Ala Uncertain significance Single submitter
- DCST2 p.Gly195Ser Uncertain significance Single submitter
- DCST2 p.Gly267Asp Uncertain significance Single submitter
- DCST2 p.Gly267Ser Uncertain significance Single submitter
- DCST2 p.Gly570Asp Uncertain significance Single submitter
- DCST2 p.Gly649Glu Uncertain significance Single submitter
- DCST2 p.Gly690Ser Uncertain significance Single submitter
- DCST2 p.Gly69Asp Uncertain significance Single submitter
- DCST2 p.Gly709Arg Uncertain significance Single submitter
- DCST2 p.His10Gln Uncertain significance Single submitter
- DCST2 p.His591Gln Uncertain significance Single submitter
- DCST2 p.Ile173Val Uncertain significance Single submitter
- DCST2 p.Ile194Val Uncertain significance Single submitter
- DCST2 p.Ile501Val Uncertain significance Single submitter
- DCST2 p.Ile729Met Uncertain significance Single submitter
- DCST2 p.Leu184Phe Uncertain significance Single submitter
- DCST2 p.Leu323Arg Uncertain significance Single submitter
- DCST2 p.Leu548Val Uncertain significance Single submitter
- DCST2 p.Leu554Met Uncertain significance Single submitter
- DCST2 p.Leu693Phe Uncertain significance Single submitter
- DCST2 p.Lys217Gln Uncertain significance Single submitter
- DCST2 p.Lys3Glu Uncertain significance Single submitter
- DCST2 p.Lys714Arg Uncertain significance Single submitter
- DCST2 p.Met221Val Uncertain significance Single submitter
- DCST2 p.Met5Ile Uncertain significance Single submitter
- DCST2 p.Met5Leu Uncertain significance Single submitter
- DCST2 p.Phe473Ser Uncertain significance Single submitter
- DCST2 p.Phe516Ser Uncertain significance Single submitter
- DCST2 p.Pro144Arg Uncertain significance Single submitter
- DCST2 p.Pro380Arg Uncertain significance Single submitter
- DCST2 p.Pro380Leu Uncertain significance Single submitter
- DCST2 p.Pro380Ser Uncertain significance Single submitter
- DCST2 p.Pro391Leu Uncertain significance Single submitter
- DCST2 p.Pro449Ala Uncertain significance Single submitter
- DCST2 p.Pro772Arg Uncertain significance Single submitter
- DCST2 p.Ser147Asn Uncertain significance Single submitter
- DCST2 p.Ser200Leu Uncertain significance Single submitter
- DCST2 p.Ser35Phe Uncertain significance Single submitter
- DCST2 p.Ser493Leu Uncertain significance Single submitter
- DCST2 p.Ser521Gly Uncertain significance Single submitter
- DCST2 p.Ser541Phe Uncertain significance Single submitter
- DCST2 p.Ser618Gly Uncertain significance Single submitter
- DCST2 p.Ser760Leu Uncertain significance Single submitter
- DCST2 p.Ser760Thr Uncertain significance Single submitter
- DCST2 p.Thr159Ser Uncertain significance Single submitter
- DCST2 p.Thr330Met Uncertain significance Single submitter
- DCST2 p.Thr459Ala Uncertain significance Single submitter
- DCST2 p.Val104Met Uncertain significance Single submitter
- DCST2 p.Val123Ile Uncertain significance Single submitter
- DCST2 p.Val248Ile Uncertain significance Single submitter
- DCST2 p.Val419Met Uncertain significance Single submitter
- DCST2 p.Val520Phe Uncertain significance Single submitter
- DCST2 p.Val57Ala Uncertain significance Single submitter
- DCST2 p.Val589Phe Uncertain significance Single submitter
- DCST2 p.Val640Leu Uncertain significance Single submitter
- DCST2 p.Val688Met Uncertain significance Single submitter
Predictors split 64
The independent predictors disagree with each other — read with care.
- DCST2 p.Ala141Thr Uncertain significance Single submitter
- DCST2 p.Arg114Cys Uncertain significance Single submitter
- DCST2 p.Arg167Cys Uncertain significance Single submitter
- DCST2 p.Arg185Trp Uncertain significance Single submitter
- DCST2 p.Arg25Cys Uncertain significance Single submitter
- DCST2 p.Arg25His Uncertain significance Single submitter
- DCST2 p.Arg263Cys Uncertain significance Single submitter
- DCST2 p.Arg276Trp Uncertain significance Single submitter
- DCST2 p.Arg299Trp Uncertain significance Single submitter
- DCST2 p.Arg320Gly Uncertain significance Single submitter
- DCST2 p.Arg320Pro Uncertain significance Single submitter
- DCST2 p.Arg345Gln Uncertain significance Single submitter
- DCST2 p.Arg365Cys Uncertain significance Single submitter
- DCST2 p.Arg365Leu Uncertain significance Single submitter
- DCST2 p.Arg370Cys Uncertain significance Single submitter
- DCST2 p.Arg388His Likely benign Single submitter
- DCST2 p.Arg467Cys Uncertain significance Single submitter
- DCST2 p.Arg467His Uncertain significance Single submitter
- DCST2 p.Arg487Cys Uncertain significance Single submitter
- DCST2 p.Arg525Gln Uncertain significance Single submitter
- DCST2 p.Arg535Gln Uncertain significance Single submitter
- DCST2 p.Arg535Trp Uncertain significance Single submitter
- DCST2 p.Arg550Cys Uncertain significance Single submitter
- DCST2 p.Arg550His Uncertain significance Single submitter
- DCST2 p.Arg551Gln Uncertain significance Single submitter
- DCST2 p.Arg564Trp Uncertain significance Single submitter
- DCST2 p.Arg565Gln Uncertain significance Single submitter
- DCST2 p.Arg565Trp Uncertain significance Single submitter
- DCST2 p.Arg581Trp Uncertain significance Single submitter
- DCST2 p.Arg632Cys Uncertain significance Single submitter
- DCST2 p.Arg74His Uncertain significance Single submitter
- DCST2 p.Arg93Gln Uncertain significance Single submitter
- DCST2 p.Arg93Trp Uncertain significance Single submitter
- DCST2 p.Asn132Asp Uncertain significance Single submitter
- DCST2 p.Asn296Ser Uncertain significance Single submitter
- DCST2 p.Glu700Lys Uncertain significance Single submitter
- DCST2 p.Glu706Lys Uncertain significance Single submitter
- DCST2 p.Gly621Ser Uncertain significance Single submitter
- DCST2 p.Leu244Pro Uncertain significance Single submitter
- DCST2 p.Leu440Arg Uncertain significance Single submitter
- DCST2 p.Leu97Phe Uncertain significance Single submitter
- DCST2 p.Phe30Leu Uncertain significance Single submitter
- DCST2 p.Pro376Leu Uncertain significance Single submitter
- DCST2 p.Pro392Gln Uncertain significance Single submitter
- DCST2 p.Pro620Arg Uncertain significance Single submitter
- DCST2 p.Ser448Arg Uncertain significance Single submitter
- DCST2 p.Ser73Phe Uncertain significance Single submitter
- DCST2 p.Ser763Cys Uncertain significance Single submitter
- DCST2 p.Thr134Ile Uncertain significance Single submitter
- DCST2 p.Thr514Ser Uncertain significance Single submitter
- DCST2 p.Tyr338His Uncertain significance Single submitter
- DCST2 p.Tyr346Cys Uncertain significance Single submitter
- DCST2 p.Tyr427Cys Uncertain significance Single submitter
- DCST2 p.Tyr500Cys Uncertain significance Single submitter
- DCST2 p.Tyr500His Uncertain significance Single submitter
- DCST2 p.Tyr507Cys Uncertain significance Single submitter
- DCST2 p.Val233Met Uncertain significance Single submitter
- DCST2 p.Val250Gly Uncertain significance Single submitter
- DCST2 p.Val270Met Uncertain significance Single submitter
- DCST2 p.Val277Met Uncertain significance Single submitter
- DCST2 p.Val293Met Uncertain significance Single submitter
- DCST2 p.Val304Ile Uncertain significance Single submitter
- DCST2 p.Val304Leu Uncertain significance Single submitter
- DCST2 p.Val76Gly Uncertain significance Single submitter
All DCST2 variants
Likely benign 10
- p.Arg118Gln Single submitter
- p.Arg157Gln Single submitter
- p.Arg388His Single submitter ⚠
- p.Arg491His Single submitter
- p.Gly14Ala Single submitter
- p.Gly716Arg Single submitter
- p.His384= Single submitter
- p.Ile513Val Single submitter
- p.Leu336Phe Single submitter
- p.Tyr461= Single submitter
Uncertain significance 159
- p.Ala135Thr Single submitter ⚠
- p.Ala141Thr Single submitter ⚠
- p.Ala20Thr Single submitter ⚠
- p.Ala341Val Single submitter ⚠
- p.Ala39Thr Single submitter ⚠
- p.Ala597Asp Single submitter ⚠
- p.Ala668Val Single submitter ⚠
- p.Ala670Val Single submitter ⚠
- p.Ala748Thr Single submitter ⚠
- p.Ala752Val Single submitter ⚠
- p.Arg114Cys Single submitter ⚠
- p.Arg114His Single submitter ⚠
- p.Arg165Trp Single submitter ⚠
- p.Arg167Cys Single submitter ⚠
- p.Arg167His Single submitter ⚠
- p.Arg185Trp Single submitter ⚠
- p.Arg25Cys Single submitter ⚠
- p.Arg25His Single submitter ⚠
- p.Arg263Cys Single submitter ⚠
- p.Arg276Gln Single submitter ⚠
- p.Arg276Trp Single submitter ⚠
- p.Arg299Gln Single submitter ⚠
- p.Arg299Trp Single submitter ⚠
- p.Arg318His Single submitter ⚠
- p.Arg320Gln Single submitter ⚠
- p.Arg320Gly Single submitter ⚠
- p.Arg320Pro Single submitter ⚠
- p.Arg345Gln Single submitter ⚠
- p.Arg365Cys Single submitter ⚠
- p.Arg365Leu Single submitter ⚠
- p.Arg370Cys Single submitter ⚠
- p.Arg388Leu Single submitter ⚠
- p.Arg447His Single submitter ⚠
- p.Arg467Cys Single submitter ⚠
- p.Arg467His Single submitter ⚠
- p.Arg486Gln Single submitter ⚠
- p.Arg487Cys Single submitter ⚠
- p.Arg487His Single submitter ⚠
- p.Arg491Ser Single submitter ⚠
- p.Arg522Trp Single submitter ⚠
- p.Arg525Gln Single submitter ⚠
- p.Arg535Gln Single submitter ⚠
- p.Arg535Trp Single submitter ⚠
- p.Arg550Cys Single submitter ⚠
- p.Arg550His Single submitter ⚠
- p.Arg551Gln Single submitter ⚠
- p.Arg564Trp Single submitter ⚠
- p.Arg565Gln Single submitter ⚠
- p.Arg565Trp Single submitter ⚠
- p.Arg581Trp Single submitter ⚠
- p.Arg632Cys Single submitter ⚠
- p.Arg74His Single submitter ⚠
- p.Arg93Gln Single submitter ⚠
- p.Arg93Trp Single submitter ⚠
- p.Asn132Asp Single submitter ⚠
- p.Asn296Ser Single submitter ⚠
- p.Asn636Lys Single submitter ⚠
- p.Asn636Ser Single submitter ⚠
- p.Asp196Asn Single submitter ⚠
- p.Asp218Glu Single submitter ⚠
- p.Asp650His Single submitter ⚠
- p.Asp652Ala Single submitter ⚠
- p.Gln441His Single submitter ⚠
- p.Gln478Arg Single submitter ⚠
- p.Gln537Arg Single submitter ⚠
- p.Gln648Glu Single submitter ⚠
- p.Gln648His Single submitter ⚠
- p.Gln664Lys Single submitter ⚠
- p.Gln75Glu Single submitter ⚠
- p.Glu310Lys Single submitter ⚠
- p.Glu385Lys Single submitter ⚠
- p.Glu408Lys Single submitter ⚠
- p.Glu538Gln Single submitter ⚠
- p.Glu538Lys Single submitter ⚠
- p.Glu700Lys Single submitter ⚠
- p.Glu706Lys Single submitter ⚠
- p.Gly13Ala Single submitter ⚠
- p.Gly195Ser Single submitter ⚠
- p.Gly267Asp Single submitter ⚠
- p.Gly267Ser Single submitter ⚠
- p.Gly570Asp Single submitter ⚠
- p.Gly621Ser Single submitter ⚠
- p.Gly649Glu Single submitter ⚠
- p.Gly690Ser Single submitter ⚠
- p.Gly69Asp Single submitter ⚠
- p.Gly709Arg Single submitter ⚠
- p.His10Gln Single submitter ⚠
- p.His591Gln Single submitter ⚠
- p.Ile173Val Single submitter ⚠
- p.Ile194Val Single submitter ⚠
- p.Ile501Val Single submitter ⚠
- p.Ile729Met Single submitter ⚠
- p.Leu184Phe Single submitter ⚠
- p.Leu244Pro Single submitter ⚠
- p.Leu323Arg Single submitter ⚠
- p.Leu440Arg Single submitter ⚠
- p.Leu548Val Single submitter ⚠
- p.Leu554Met Single submitter ⚠
- p.Leu693Phe Single submitter ⚠
- p.Leu97Phe Single submitter ⚠
- p.Lys217Gln Single submitter ⚠
- p.Lys3Glu Single submitter ⚠
- p.Lys714Arg Single submitter ⚠
- p.Met221Val Single submitter ⚠
- p.Met5Ile Single submitter ⚠
- p.Met5Leu Single submitter ⚠
- p.Phe30Leu Single submitter ⚠
- p.Phe473Ser Single submitter ⚠
- p.Phe516Ser Single submitter ⚠
- p.Pro144Arg Single submitter ⚠
- p.Pro376Leu Single submitter ⚠
- p.Pro380Arg Single submitter ⚠
- p.Pro380Leu Single submitter ⚠
- p.Pro380Ser Single submitter ⚠
- p.Pro391Leu Single submitter ⚠
- p.Pro392Gln Single submitter ⚠
- p.Pro449Ala Single submitter ⚠
- p.Pro620Arg Single submitter ⚠
- p.Pro772Arg Single submitter ⚠
- p.Ser147Asn Single submitter ⚠
- p.Ser200Leu Single submitter ⚠
- p.Ser35Phe Single submitter ⚠
- p.Ser448Arg Single submitter ⚠
- p.Ser493Leu Single submitter ⚠
- p.Ser521Gly Single submitter ⚠
- p.Ser541Phe Single submitter ⚠
- p.Ser618Gly Single submitter ⚠
- p.Ser73Phe Single submitter ⚠
- p.Ser760Leu Single submitter ⚠
- p.Ser760Thr Single submitter ⚠
- p.Ser763Cys Single submitter ⚠
- p.Thr134Ile Single submitter ⚠
- p.Thr159Ser Single submitter ⚠
- p.Thr330Met Single submitter ⚠
- p.Thr459Ala Single submitter ⚠
- p.Thr514Ser Single submitter ⚠
- p.Tyr338His Single submitter ⚠
- p.Tyr346Cys Single submitter ⚠
- p.Tyr427Cys Single submitter ⚠
- p.Tyr500Cys Single submitter ⚠
- p.Tyr500His Single submitter ⚠
- p.Tyr507Cys Single submitter ⚠
- p.Val104Met Single submitter ⚠
- p.Val123Ile Single submitter ⚠
- p.Val233Met Single submitter ⚠
- p.Val248Ile Single submitter ⚠
- p.Val250Gly Single submitter ⚠
- p.Val270Met Single submitter ⚠
- p.Val277Met Single submitter ⚠
- p.Val293Met Single submitter ⚠
- p.Val304Ile Single submitter ⚠
- p.Val304Leu Single submitter ⚠
- p.Val419Met Single submitter ⚠
- p.Val520Phe Single submitter ⚠
- p.Val57Ala Single submitter ⚠
- p.Val589Phe Single submitter ⚠
- p.Val640Leu Single submitter ⚠
- p.Val688Met Single submitter ⚠
- p.Val76Gly Single submitter ⚠