DCSTAMP — 63 ClinVar variants
All ClinVar germline DCSTAMP variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 52 flagged for review →
1 Benign · 7 Likely benign · 55 Uncertain significance
Full DCSTAMP gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 52
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 44
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DCSTAMP p.Arg92His Uncertain significance Single submitter
- DCSTAMP p.Asp349Glu Uncertain significance Single submitter
- DCSTAMP p.Asp468His Uncertain significance Single submitter
- DCSTAMP p.Cys74Phe Uncertain significance Single submitter
- DCSTAMP p.Cys74Trp Uncertain significance Single submitter
- DCSTAMP p.Gln185Arg Uncertain significance Single submitter
- DCSTAMP p.Gln345Pro Uncertain significance Single submitter
- DCSTAMP p.Glu289Gln Uncertain significance Single submitter
- DCSTAMP p.Gly25Arg Uncertain significance Single submitter
- DCSTAMP p.Gly2Arg Uncertain significance Single submitter
- DCSTAMP p.Gly94Asp Uncertain significance Single submitter
- DCSTAMP p.His137Arg Uncertain significance Single submitter
- DCSTAMP p.Ile105Phe Uncertain significance Single submitter
- DCSTAMP p.Ile245Phe Uncertain significance Single submitter
- DCSTAMP p.Ile279Asn Uncertain significance Single submitter
- DCSTAMP p.Ile306Met Uncertain significance Single submitter
- DCSTAMP p.Ile306Val Uncertain significance Single submitter
- DCSTAMP p.Ile350Thr Uncertain significance Single submitter
- DCSTAMP p.Ile42Leu Uncertain significance Single submitter
- DCSTAMP p.Ile82Phe Uncertain significance Single submitter
- DCSTAMP p.Leu121Arg Uncertain significance Single submitter
- DCSTAMP p.Leu197Phe Uncertain significance Single submitter
- DCSTAMP p.Leu380Pro Uncertain significance Single submitter
- DCSTAMP p.Leu433Arg Uncertain significance Single submitter
- DCSTAMP p.Leu83Val Uncertain significance Single submitter
- DCSTAMP p.Lys370Asn Uncertain significance Single submitter
- DCSTAMP p.Lys415Arg Uncertain significance Single submitter
- DCSTAMP p.Lys76Glu Uncertain significance Single submitter
- DCSTAMP p.Met200Lys Uncertain significance Single submitter
- DCSTAMP p.Met456Thr Uncertain significance Single submitter
- DCSTAMP p.Phe361Ser Uncertain significance Single submitter
- DCSTAMP p.Ser174Phe Uncertain significance Single submitter
- DCSTAMP p.Ser209Pro Uncertain significance Single submitter
- DCSTAMP p.Ser323Leu Uncertain significance Single submitter
- DCSTAMP p.Ser441Thr Uncertain significance Single submitter
- DCSTAMP p.Thr156Ile Uncertain significance Single submitter
- DCSTAMP p.Thr286Ile Uncertain significance Single submitter
- DCSTAMP p.Thr376Ile Uncertain significance Single submitter
- DCSTAMP p.Trp65Cys Uncertain significance Single submitter
- DCSTAMP p.Tyr315Phe Uncertain significance Single submitter
- DCSTAMP p.Val106Ile Uncertain significance Single submitter
- DCSTAMP p.Val111Ile Uncertain significance Single submitter
- DCSTAMP p.Val173Ala Uncertain significance Single submitter
- DCSTAMP p.Val19Met Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- DCSTAMP p.Arg259Thr Uncertain significance Single submitter
- DCSTAMP p.Gly104Arg Uncertain significance Single submitter
- DCSTAMP p.Leu440Pro Uncertain significance Single submitter
- DCSTAMP p.Phe296Leu Uncertain significance Single submitter
- DCSTAMP p.Phe449Leu Uncertain significance Single submitter
- DCSTAMP p.Thr68Lys Uncertain significance Single submitter
- DCSTAMP p.Tyr246Cys Uncertain significance Single submitter
- DCSTAMP p.Tyr315Asp Uncertain significance Single submitter
All DCSTAMP variants
Benign 1
- p.Asp349Gly Multiple submitters
Likely benign 7
- p.Asn270Ser Single submitter
- p.Gly236Asp Single submitter
- p.Ile279Val Single submitter
- p.Pro285Leu Single submitter
- p.Val196Ile Single submitter
- p.Val313Ile Single submitter
- p.Val412Met Single submitter
Uncertain significance 55
- p.Arg259Thr Single submitter ⚠
- p.Arg92His Single submitter ⚠
- p.Asp349Glu Single submitter ⚠
- p.Asp468His Single submitter ⚠
- p.Cys74Phe Single submitter ⚠
- p.Cys74Trp Single submitter ⚠
- p.Gln185Arg Single submitter ⚠
- p.Gln345Pro Single submitter ⚠
- p.Glu289Gln Single submitter ⚠
- p.Gly104Arg Single submitter ⚠
- p.Gly25Arg Single submitter ⚠
- p.Gly2Arg Single submitter ⚠
- p.Gly94Asp Single submitter ⚠
- p.His137Arg Single submitter ⚠
- p.Ile105Phe Single submitter ⚠
- p.Ile245Phe Single submitter ⚠
- p.Ile279Asn Single submitter ⚠
- p.Ile306Met Single submitter ⚠
- p.Ile306Val Single submitter ⚠
- p.Ile350Thr Single submitter ⚠
- p.Ile383Thr Single submitter
- p.Ile42Leu Single submitter ⚠
- p.Ile82Phe Single submitter ⚠
- p.Leu121Arg Single submitter ⚠
- p.Leu197Phe Single submitter ⚠
- p.Leu224Pro Single submitter
- p.Leu380Pro Single submitter ⚠
- p.Leu433Arg Single submitter ⚠
- p.Leu440Pro Single submitter ⚠
- p.Leu83Val Single submitter ⚠
- p.Lys370Asn Single submitter ⚠
- p.Lys415Arg Single submitter ⚠
- p.Lys76Glu Single submitter ⚠
- p.Met200Lys Single submitter ⚠
- p.Met456Thr Single submitter ⚠
- p.Phe251Tyr Single submitter
- p.Phe296Leu Single submitter ⚠
- p.Phe361Ser Single submitter ⚠
- p.Phe449Leu Single submitter ⚠
- p.Ser174Phe Single submitter ⚠
- p.Ser209Pro Single submitter ⚠
- p.Ser323Leu Single submitter ⚠
- p.Ser441Thr Single submitter ⚠
- p.Thr156Ile Single submitter ⚠
- p.Thr286Ile Single submitter ⚠
- p.Thr376Ile Single submitter ⚠
- p.Thr68Lys Single submitter ⚠
- p.Trp65Cys Single submitter ⚠
- p.Tyr246Cys Single submitter ⚠
- p.Tyr315Asp Single submitter ⚠
- p.Tyr315Phe Single submitter ⚠
- p.Val106Ile Single submitter ⚠
- p.Val111Ile Single submitter ⚠
- p.Val173Ala Single submitter ⚠
- p.Val19Met Single submitter ⚠