DCTD — 29 ClinVar variants
All ClinVar germline DCTD variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 28 flagged for review →
1 Benign · 28 Uncertain significance
Full DCTD gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 28
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 14
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DCTD p.Ala23Gly Uncertain significance Single submitter
- DCTD p.Ala39Thr Uncertain significance Single submitter
- DCTD p.Asn54Ser Uncertain significance Single submitter
- DCTD p.Cys40Tyr Uncertain significance Single submitter
- DCTD p.Gly38Ser Uncertain significance Single submitter
- DCTD p.Gly50Trp Uncertain significance Single submitter
- DCTD p.Lys115Thr Uncertain significance Single submitter
- DCTD p.Lys176Asn Uncertain significance Single submitter
- DCTD p.Phe108Leu Uncertain significance Single submitter
- DCTD p.Phe166Cys Uncertain significance Single submitter
- DCTD p.Pro157Gln Uncertain significance Single submitter
- DCTD p.Pro66Ser Uncertain significance Single submitter
- DCTD p.Val150Met Uncertain significance Single submitter
- DCTD p.Val42Met Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- DCTD p.Arg153Trp Uncertain significance Single submitter
- DCTD p.Asp76Val Uncertain significance Single submitter
- DCTD p.Asp97Glu Uncertain significance Single submitter
- DCTD p.Glu137Lys Uncertain significance Single submitter
- DCTD p.Gly149Arg Uncertain significance Single submitter
- DCTD p.His133Arg Uncertain significance Single submitter
- DCTD p.Lys161Arg Uncertain significance Single submitter
- DCTD p.Phe24Leu Uncertain significance Single submitter
- DCTD p.Pro173Leu Uncertain significance Single submitter
- DCTD p.Ser160Gly Uncertain significance Single submitter
- DCTD p.Ser61Cys Uncertain significance Single submitter
- DCTD p.Ser61Gly Uncertain significance Single submitter
- DCTD p.Thr139Asn Uncertain significance Single submitter
- DCTD p.Val150Leu Uncertain significance Single submitter
All DCTD variants
Benign 1
- p.Ala85= Multiple submitters
Uncertain significance 28
- p.Ala23Gly Single submitter ⚠
- p.Ala39Thr Single submitter ⚠
- p.Arg153Trp Single submitter ⚠
- p.Asn54Ser Single submitter ⚠
- p.Asp76Val Single submitter ⚠
- p.Asp97Glu Single submitter ⚠
- p.Cys40Tyr Single submitter ⚠
- p.Glu137Lys Single submitter ⚠
- p.Gly149Arg Single submitter ⚠
- p.Gly38Ser Single submitter ⚠
- p.Gly50Trp Single submitter ⚠
- p.His133Arg Single submitter ⚠
- p.Lys115Thr Single submitter ⚠
- p.Lys161Arg Single submitter ⚠
- p.Lys176Asn Single submitter ⚠
- p.Phe108Leu Single submitter ⚠
- p.Phe166Cys Single submitter ⚠
- p.Phe24Leu Single submitter ⚠
- p.Pro157Gln Single submitter ⚠
- p.Pro173Leu Single submitter ⚠
- p.Pro66Ser Single submitter ⚠
- p.Ser160Gly Single submitter ⚠
- p.Ser61Cys Single submitter ⚠
- p.Ser61Gly Single submitter ⚠
- p.Thr139Asn Single submitter ⚠
- p.Val150Leu Single submitter ⚠
- p.Val150Met Single submitter ⚠
- p.Val42Met Single submitter ⚠