DCTN6 — 24 ClinVar variants
All ClinVar germline DCTN6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 23 flagged for review →
1 Likely benign · 23 Uncertain significance
Full DCTN6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 23
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 17
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DCTN6 p.Ala127Val Uncertain significance Single submitter
- DCTN6 p.Ala60Ser Uncertain significance Single submitter
- DCTN6 p.Arg150Cys Uncertain significance Single submitter
- DCTN6 p.Arg151Gln Uncertain significance Single submitter
- DCTN6 p.Arg151Trp Uncertain significance Single submitter
- DCTN6 p.Asn190Ile Uncertain significance Single submitter
- DCTN6 p.Asn69Asp Uncertain significance Single submitter
- DCTN6 p.Asp147His Uncertain significance Single submitter
- DCTN6 p.Asp73Asn Uncertain significance Single submitter
- DCTN6 p.Ile124Val Uncertain significance Single submitter
- DCTN6 p.Ile137Val Uncertain significance Single submitter
- DCTN6 p.Ile143Thr Uncertain significance Single submitter
- DCTN6 p.Ile83Val Uncertain significance Single submitter
- DCTN6 p.Met99Val Uncertain significance Single submitter
- DCTN6 p.Pro72Ala Uncertain significance Single submitter
- DCTN6 p.Pro79Ser Uncertain significance Single submitter
- DCTN6 p.Val9Met Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- DCTN6 p.Ala2Val Uncertain significance Single submitter
- DCTN6 p.Gln59Arg Uncertain significance Single submitter
- DCTN6 p.Glu52Lys Uncertain significance Single submitter
- DCTN6 p.Ile48Val Uncertain significance Single submitter
- DCTN6 p.Pro159Arg Uncertain significance Single submitter
- DCTN6 p.Thr154Ile Uncertain significance Single submitter
All DCTN6 variants
Likely benign 1
- p.Tyr66His Single submitter
Uncertain significance 23
- p.Ala127Val Single submitter ⚠
- p.Ala2Val Single submitter ⚠
- p.Ala60Ser Single submitter ⚠
- p.Arg150Cys Single submitter ⚠
- p.Arg151Gln Single submitter ⚠
- p.Arg151Trp Single submitter ⚠
- p.Asn190Ile Single submitter ⚠
- p.Asn69Asp Single submitter ⚠
- p.Asp147His Single submitter ⚠
- p.Asp73Asn Single submitter ⚠
- p.Gln59Arg Single submitter ⚠
- p.Glu52Lys Single submitter ⚠
- p.Ile124Val Single submitter ⚠
- p.Ile137Val Single submitter ⚠
- p.Ile143Thr Single submitter ⚠
- p.Ile48Val Single submitter ⚠
- p.Ile83Val Single submitter ⚠
- p.Met99Val Single submitter ⚠
- p.Pro159Arg Single submitter ⚠
- p.Pro72Ala Single submitter ⚠
- p.Pro79Ser Single submitter ⚠
- p.Thr154Ile Single submitter ⚠
- p.Val9Met Single submitter ⚠