DCUN1D1 — 15 ClinVar variants
All ClinVar germline DCUN1D1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 14 flagged for review →
1 Benign · 14 Uncertain significance
Full DCUN1D1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 14
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 8
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DCUN1D1 p.Arg153Gln Uncertain significance Single submitter
- DCUN1D1 p.Glu116Lys Uncertain significance Single submitter
- DCUN1D1 p.Ile134Thr Uncertain significance Single submitter
- DCUN1D1 p.Ile251Val Uncertain significance Single submitter
- DCUN1D1 p.Leu148Ser Uncertain significance Single submitter
- DCUN1D1 p.Met123Val Uncertain significance Single submitter
- DCUN1D1 p.Phe122Leu Uncertain significance Single submitter
- DCUN1D1 p.Ser101Thr Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- DCUN1D1 p.Asn43Asp Uncertain significance Single submitter
- DCUN1D1 p.Asp96Asn Uncertain significance Single submitter
- DCUN1D1 p.Ile105Val Uncertain significance Single submitter
- DCUN1D1 p.Ile83Val Uncertain significance Single submitter
- DCUN1D1 p.Ser220Cys Uncertain significance Single submitter
- DCUN1D1 p.Val39Leu Uncertain significance Single submitter
All DCUN1D1 variants
Benign 1
- c.4-3T>C Multiple submitters
Uncertain significance 14
- p.Arg153Gln Single submitter ⚠
- p.Asn43Asp Single submitter ⚠
- p.Asp96Asn Single submitter ⚠
- p.Glu116Lys Single submitter ⚠
- p.Ile105Val Single submitter ⚠
- p.Ile134Thr Single submitter ⚠
- p.Ile251Val Single submitter ⚠
- p.Ile83Val Single submitter ⚠
- p.Leu148Ser Single submitter ⚠
- p.Met123Val Single submitter ⚠
- p.Phe122Leu Single submitter ⚠
- p.Ser101Thr Single submitter ⚠
- p.Ser220Cys Single submitter ⚠
- p.Val39Leu Single submitter ⚠