DCUN1D2 — 51 ClinVar variants
All ClinVar germline DCUN1D2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 47 flagged for review →
1 Likely benign · 50 Uncertain significance
Full DCUN1D2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 47
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 29
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DCUN1D2 p.Ala165Thr Uncertain significance Single submitter
- DCUN1D2 p.Arg256His Uncertain significance Single submitter
- DCUN1D2 p.Asn221Ser Uncertain significance Single submitter
- DCUN1D2 p.Asp10Asn Uncertain significance Single submitter
- DCUN1D2 p.Asp231Asn Uncertain significance Single submitter
- DCUN1D2 p.Asp242Glu Uncertain significance Single submitter
- DCUN1D2 p.Asp84Asn Uncertain significance Single submitter
- DCUN1D2 p.Asp84Gly Uncertain significance Single submitter
- DCUN1D2 p.Glu34Gly Uncertain significance Single submitter
- DCUN1D2 p.Glu39Lys Uncertain significance Single submitter
- DCUN1D2 p.Gly22Ala Uncertain significance Single submitter
- DCUN1D2 p.Ile100Thr Uncertain significance Single submitter
- DCUN1D2 p.Ile100Val Uncertain significance Single submitter
- DCUN1D2 p.Leu137Pro Uncertain significance Single submitter
- DCUN1D2 p.Leu37Ile Uncertain significance Single submitter
- DCUN1D2 p.Leu95Pro Uncertain significance Single submitter
- DCUN1D2 p.Lys171Arg Uncertain significance Single submitter
- DCUN1D2 p.Lys255Glu Uncertain significance Single submitter
- DCUN1D2 p.Lys62Glu Uncertain significance Single submitter
- DCUN1D2 p.Lys63Arg Uncertain significance Single submitter
- DCUN1D2 p.Met222Thr Uncertain significance Single submitter
- DCUN1D2 p.Met227Thr Uncertain significance Single submitter
- DCUN1D2 p.Ser118Arg Uncertain significance Single submitter
- DCUN1D2 p.Ser257Asn Uncertain significance Single submitter
- DCUN1D2 p.Thr163Ala Uncertain significance Single submitter
- DCUN1D2 p.Thr212Ile Uncertain significance Single submitter
- DCUN1D2 p.Thr31Met Uncertain significance Single submitter
- DCUN1D2 p.Trp213Arg Uncertain significance Single submitter
- DCUN1D2 p.Tyr230Cys Uncertain significance Single submitter
Predictors split 18
The independent predictors disagree with each other — read with care.
- DCUN1D2 p.Ala152Pro Uncertain significance Single submitter
- DCUN1D2 p.Ala180Gly Uncertain significance Single submitter
- DCUN1D2 p.Ala224Val Uncertain significance Single submitter
- DCUN1D2 p.Arg248Trp Uncertain significance Single submitter
- DCUN1D2 p.Asp49Val Uncertain significance Single submitter
- DCUN1D2 p.Asp91Gly Uncertain significance Single submitter
- DCUN1D2 p.Gln32Pro Uncertain significance Single submitter
- DCUN1D2 p.Gln46Lys Uncertain significance Single submitter
- DCUN1D2 p.Gln88Pro Uncertain significance Single submitter
- DCUN1D2 p.Glu147Lys Uncertain significance Single submitter
- DCUN1D2 p.Glu23Lys Uncertain significance Single submitter
- DCUN1D2 p.Leu129Phe Uncertain significance Single submitter
- DCUN1D2 p.Leu195Val Uncertain significance Single submitter
- DCUN1D2 p.Lys136Gln Uncertain significance Single submitter
- DCUN1D2 p.Thr127Arg Uncertain significance Single submitter
- DCUN1D2 p.Thr198Ile Uncertain significance Single submitter
- DCUN1D2 p.Val238Ile Uncertain significance Single submitter
-
DCUN1D2 p.Arg13His
Uncertain significance
No assertion criteria
epidermolysis bullosa simplex with nail dystrophy
All DCUN1D2 variants
Likely benign 1
- p.Ser43Asn Single submitter
Uncertain significance 50
- p.Ala152Pro Single submitter ⚠
- p.Ala165Thr Single submitter ⚠
- p.Ala180Gly Single submitter ⚠
- p.Ala224Val Single submitter ⚠
- p.Arg248Trp Single submitter ⚠
- p.Arg256His Single submitter ⚠
- p.Asn221Ser Single submitter ⚠
- p.Asp10Asn Single submitter ⚠
- p.Asp231Asn Single submitter ⚠
- p.Asp242Glu Single submitter ⚠
- p.Asp49Val Single submitter ⚠
- p.Asp84Asn Single submitter ⚠
- p.Asp84Gly Single submitter ⚠
- p.Asp91Gly Single submitter ⚠
- p.Asp96Val Single submitter
- p.Gln32Pro Single submitter ⚠
- p.Gln46Lys Single submitter ⚠
- p.Gln88Pro Single submitter ⚠
- p.Glu147Lys Single submitter ⚠
- p.Glu23Lys Single submitter ⚠
- p.Glu34Gly Single submitter ⚠
- p.Glu39Lys Single submitter ⚠
- p.Gly22Ala Single submitter ⚠
- p.Gly82Arg Single submitter
- p.Ile100Thr Single submitter ⚠
- p.Ile100Val Single submitter ⚠
- p.Leu129Phe Single submitter ⚠
- p.Leu137Pro Single submitter ⚠
- p.Leu195Val Single submitter ⚠
- p.Leu37Ile Single submitter ⚠
- p.Leu95Pro Single submitter ⚠
- p.Lys136Gln Single submitter ⚠
- p.Lys171Arg Single submitter ⚠
- p.Lys255Glu Single submitter ⚠
- p.Lys62Glu Single submitter ⚠
- p.Lys63Arg Single submitter ⚠
- p.Met222Thr Single submitter ⚠
- p.Met227Thr Single submitter ⚠
- p.Met227Val Single submitter
- p.Ser118Arg Single submitter ⚠
- p.Ser257Asn Single submitter ⚠
- p.Thr127Arg Single submitter ⚠
- p.Thr163Ala Single submitter ⚠
- p.Thr198Ile Single submitter ⚠
- p.Thr212Ile Single submitter ⚠
- p.Thr31Met Single submitter ⚠
- p.Trp213Arg Single submitter ⚠
- p.Tyr230Cys Single submitter ⚠
- p.Val238Ile Single submitter ⚠
- p.Arg13His No assertion criteria epidermolysis bullosa simplex with nail dystrophy ⚠