DDAH2 — 15 ClinVar variants
All ClinVar germline DDAH2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 13 flagged for review →
2 Benign · 13 Uncertain significance
Full DDAH2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 13
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 6
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DDAH2 p.Asp84Val Uncertain significance Single submitter
- DDAH2 p.Gly26Arg Uncertain significance Single submitter
- DDAH2 p.His205Arg Uncertain significance Single submitter
- DDAH2 p.Met178Leu Uncertain significance Single submitter
- DDAH2 p.Thr203Ala Uncertain significance Single submitter
- DDAH2 p.Val152Leu Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- DDAH2 p.Ala270Thr Uncertain significance Single submitter
- DDAH2 p.Arg237Cys Uncertain significance Single submitter
- DDAH2 p.Gly269Val Uncertain significance Single submitter
- DDAH2 p.Leu242Pro Uncertain significance Single submitter
- DDAH2 p.Ser285Ile Uncertain significance Single submitter
- DDAH2 p.Thr155Met Uncertain significance Single submitter
- DDAH2 p.Thr183Ile Uncertain significance Single submitter
All DDAH2 variants
Benign 2
- c.397+10G>C Single submitter
- p.Pro4Arg Single submitter
Uncertain significance 13
- p.Ala270Thr Single submitter ⚠
- p.Arg237Cys Single submitter ⚠
- p.Asp84Val Single submitter ⚠
- p.Gly269Val Single submitter ⚠
- p.Gly26Arg Single submitter ⚠
- p.His205Arg Single submitter ⚠
- p.Leu242Pro Single submitter ⚠
- p.Met178Leu Single submitter ⚠
- p.Ser285Ile Single submitter ⚠
- p.Thr155Met Single submitter ⚠
- p.Thr183Ile Single submitter ⚠
- p.Thr203Ala Single submitter ⚠
- p.Val152Leu Single submitter ⚠