DDIAS — 129 ClinVar variants
All ClinVar germline DDIAS variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 115 flagged for review →
15 Likely benign · 114 Uncertain significance
Full DDIAS gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 115
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 100
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DDIAS p.Ala260Val Uncertain significance Single submitter
- DDIAS p.Ala389Ser Uncertain significance Single submitter
- DDIAS p.Ala402Val Uncertain significance Single submitter
- DDIAS p.Ala438Gly Uncertain significance Single submitter
- DDIAS p.Ala478Asp Uncertain significance Single submitter
- DDIAS p.Ala675Gly Uncertain significance Single submitter
- DDIAS p.Ala927Val Uncertain significance Single submitter
- DDIAS p.Ala991Gly Uncertain significance Single submitter
- DDIAS p.Arg3Lys Uncertain significance Single submitter
- DDIAS p.Arg460Lys Uncertain significance Single submitter
- DDIAS p.Arg467Lys Uncertain significance Single submitter
- DDIAS p.Arg560Gly Uncertain significance Single submitter
- DDIAS p.Arg743Lys Uncertain significance Single submitter
- DDIAS p.Arg743Thr Uncertain significance Single submitter
- DDIAS p.Asn106Asp Uncertain significance Single submitter
- DDIAS p.Asn40His Uncertain significance Single submitter
- DDIAS p.Asn40Ser Uncertain significance Single submitter
- DDIAS p.Asn449Thr Uncertain significance Single submitter
- DDIAS p.Asn660His Uncertain significance Single submitter
- DDIAS p.Asn913Ser Uncertain significance Single submitter
- DDIAS p.Asp213His Uncertain significance Single submitter
- DDIAS p.Asp221Asn Uncertain significance Single submitter
- DDIAS p.Asp450Asn Uncertain significance Single submitter
- DDIAS p.Asp528Glu Uncertain significance Single submitter
- DDIAS p.Asp688Gly Uncertain significance Single submitter
- DDIAS p.Cys230Ser Uncertain significance Single submitter
- DDIAS p.Cys391Phe Uncertain significance Single submitter
- DDIAS p.Cys41Tyr Uncertain significance Single submitter
- DDIAS p.Cys607Tyr Uncertain significance Single submitter
- DDIAS p.Cys973Arg Uncertain significance Single submitter
- DDIAS p.Gln110Arg Uncertain significance Single submitter
- DDIAS p.Gln737Arg Uncertain significance Single submitter
- DDIAS p.Gln817Glu Uncertain significance Single submitter
- DDIAS p.Gln95His Uncertain significance Single submitter
- DDIAS p.Glu102Gln Uncertain significance Single submitter
- DDIAS p.Glu134Gly Uncertain significance Single submitter
- DDIAS p.Glu361Lys Uncertain significance Single submitter
- DDIAS p.Glu518Gln Uncertain significance Single submitter
- DDIAS p.Glu566Asp Uncertain significance Single submitter
- DDIAS p.Glu566Lys Uncertain significance Single submitter
- DDIAS p.Glu715Lys Uncertain significance Single submitter
- DDIAS p.Glu855Asp Uncertain significance Single submitter
- DDIAS p.Glu987Lys Uncertain significance Single submitter
- DDIAS p.Gly140Val Uncertain significance Single submitter
- DDIAS p.Gly377Cys Uncertain significance Single submitter
- DDIAS p.Gly879Arg Uncertain significance Single submitter
- DDIAS p.His153Arg Uncertain significance Single submitter
- DDIAS p.His182Arg Uncertain significance Single submitter
- DDIAS p.His326Pro Uncertain significance Single submitter
- DDIAS p.His744Pro Uncertain significance Single submitter
- DDIAS p.His857Arg Uncertain significance Single submitter
- DDIAS p.His907Pro Uncertain significance Single submitter
- DDIAS p.His935Arg Uncertain significance Single submitter
- DDIAS p.Ile657Thr Uncertain significance Single submitter
- DDIAS p.Ile667Val Uncertain significance Single submitter
- DDIAS p.Ile689Val Uncertain significance Single submitter
- DDIAS p.Ile883Val Uncertain significance Single submitter
- DDIAS p.Ile951Met Uncertain significance Single submitter
- DDIAS p.Ile951Val Uncertain significance Single submitter
- DDIAS p.Leu204Ser Uncertain significance Single submitter
- DDIAS p.Leu298Pro Uncertain significance Single submitter
- DDIAS p.Leu315Phe Uncertain significance Single submitter
- DDIAS p.Leu461Ser Uncertain significance Single submitter
- DDIAS p.Lys313Arg Uncertain significance Single submitter
- DDIAS p.Lys500Gln Uncertain significance Single submitter
- DDIAS p.Lys931Arg Uncertain significance Single submitter
- DDIAS p.Lys940Glu Uncertain significance Single submitter
- DDIAS p.Lys972Arg Uncertain significance Single submitter
- DDIAS p.Phe146Leu Uncertain significance Single submitter
- DDIAS p.Phe190Ile Uncertain significance Single submitter
- DDIAS p.Phe625Ser Uncertain significance Single submitter
- DDIAS p.Phe768Tyr Uncertain significance Single submitter
- DDIAS p.Phe797Leu Uncertain significance Single submitter
- DDIAS p.Phe811Leu Uncertain significance Single submitter
- DDIAS p.Pro393Ser Uncertain significance Single submitter
- DDIAS p.Pro821Ser Uncertain significance Single submitter
- DDIAS p.Pro983Leu Uncertain significance Single submitter
- DDIAS p.Ser264Asn Uncertain significance Single submitter
- DDIAS p.Ser30Cys Uncertain significance Single submitter
- DDIAS p.Ser351Ile Uncertain significance Single submitter
- DDIAS p.Ser394Leu Uncertain significance Single submitter
- DDIAS p.Ser570Cys Uncertain significance Single submitter
- DDIAS p.Ser584Pro Uncertain significance Single submitter
- DDIAS p.Ser765Thr Uncertain significance Single submitter
- DDIAS p.Ser799Leu Uncertain significance Single submitter
- DDIAS p.Thr114Ser Uncertain significance Single submitter
- DDIAS p.Thr131Met Uncertain significance Single submitter
- DDIAS p.Thr382Ala Uncertain significance Single submitter
- DDIAS p.Thr751Ala Uncertain significance Single submitter
- DDIAS p.Thr859Ile Uncertain significance Single submitter
- DDIAS p.Thr88Ser Uncertain significance Single submitter
- DDIAS p.Tyr55Asp Uncertain significance Single submitter
- DDIAS p.Tyr669Cys Uncertain significance Single submitter
- DDIAS p.Tyr673Cys Uncertain significance Single submitter
- DDIAS p.Tyr851His Uncertain significance Single submitter
- DDIAS p.Val35Ile Uncertain significance Single submitter
- DDIAS p.Val769Phe Uncertain significance Single submitter
- DDIAS p.Val847Ile Uncertain significance Single submitter
- DDIAS p.Val865Leu Uncertain significance Single submitter
- DDIAS p.Val953Ile Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- DDIAS p.Ala14Thr Uncertain significance Single submitter
- DDIAS p.Asp682Val Uncertain significance Single submitter
- DDIAS p.Cys973Trp Uncertain significance Single submitter
- DDIAS p.Ile32Met Uncertain significance Single submitter
- DDIAS p.Leu104Met Uncertain significance Single submitter
- DDIAS p.Leu104Pro Uncertain significance Single submitter
- DDIAS p.Ser229Tyr Uncertain significance Single submitter
- DDIAS p.Ser355Phe Uncertain significance Single submitter
- DDIAS p.Ser366Tyr Uncertain significance Single submitter
- DDIAS p.Ser431Arg Uncertain significance Single submitter
- DDIAS p.Ser738Arg Uncertain significance Single submitter
- DDIAS p.Ser749Phe Uncertain significance Single submitter
- DDIAS p.Thr474Arg Uncertain significance Single submitter
- DDIAS p.Thr930Met Likely benign Single submitter
- DDIAS p.Tyr55His Uncertain significance Single submitter
All DDIAS variants
Likely benign 15
- p.Arg989Gln Single submitter
- p.Asp208Glu Single submitter
- p.Cys490Ser Single submitter
- p.Glu321Gln Single submitter
- p.Gly886Arg Single submitter
- p.Ile172Val Single submitter
- p.Ile777Val Single submitter
- p.Ile838Val Single submitter
- p.Lys232Arg Single submitter
- p.Lys599Arg Single submitter
- p.Phe245Leu Single submitter
- p.Phe454Leu Single submitter
- p.Pro949Ser Single submitter
- p.Thr930Met Single submitter ⚠
- p.Val661Ile Single submitter
Uncertain significance 114
- p.Ala14Thr Single submitter ⚠
- p.Ala260Val Single submitter ⚠
- p.Ala389Ser Single submitter ⚠
- p.Ala402Val Single submitter ⚠
- p.Ala438Gly Single submitter ⚠
- p.Ala478Asp Single submitter ⚠
- p.Ala675Gly Single submitter ⚠
- p.Ala927Val Single submitter ⚠
- p.Ala991Gly Single submitter ⚠
- p.Arg3Lys Single submitter ⚠
- p.Arg460Lys Single submitter ⚠
- p.Arg467Lys Single submitter ⚠
- p.Arg560Gly Single submitter ⚠
- p.Arg743Lys Single submitter ⚠
- p.Arg743Thr Single submitter ⚠
- p.Asn106Asp Single submitter ⚠
- p.Asn40His Single submitter ⚠
- p.Asn40Ser Single submitter ⚠
- p.Asn449Thr Single submitter ⚠
- p.Asn660His Single submitter ⚠
- p.Asn913Ser Single submitter ⚠
- p.Asp213His Single submitter ⚠
- p.Asp221Asn Single submitter ⚠
- p.Asp450Asn Single submitter ⚠
- p.Asp528Glu Single submitter ⚠
- p.Asp682Val Single submitter ⚠
- p.Asp688Gly Single submitter ⚠
- p.Cys230Ser Single submitter ⚠
- p.Cys391Phe Single submitter ⚠
- p.Cys41Tyr Single submitter ⚠
- p.Cys607Tyr Single submitter ⚠
- p.Cys973Arg Single submitter ⚠
- p.Cys973Trp Single submitter ⚠
- p.Gln110Arg Single submitter ⚠
- p.Gln737Arg Single submitter ⚠
- p.Gln817Glu Single submitter ⚠
- p.Gln95His Single submitter ⚠
- p.Glu102Gln Single submitter ⚠
- p.Glu134Gly Single submitter ⚠
- p.Glu361Lys Single submitter ⚠
- p.Glu518Gln Single submitter ⚠
- p.Glu566Asp Single submitter ⚠
- p.Glu566Lys Single submitter ⚠
- p.Glu715Lys Single submitter ⚠
- p.Glu855Asp Single submitter ⚠
- p.Glu987Lys Single submitter ⚠
- p.Gly140Val Single submitter ⚠
- p.Gly377Cys Single submitter ⚠
- p.Gly879Arg Single submitter ⚠
- p.His153Arg Single submitter ⚠
- p.His182Arg Single submitter ⚠
- p.His326Pro Single submitter ⚠
- p.His744Pro Single submitter ⚠
- p.His857Arg Single submitter ⚠
- p.His907Pro Single submitter ⚠
- p.His935Arg Single submitter ⚠
- p.Ile32Met Single submitter ⚠
- p.Ile657Thr Single submitter ⚠
- p.Ile667Val Single submitter ⚠
- p.Ile689Val Single submitter ⚠
- p.Ile883Val Single submitter ⚠
- p.Ile951Met Single submitter ⚠
- p.Ile951Val Single submitter ⚠
- p.Leu104Met Single submitter ⚠
- p.Leu104Pro Single submitter ⚠
- p.Leu204Ser Single submitter ⚠
- p.Leu298Pro Single submitter ⚠
- p.Leu315Phe Single submitter ⚠
- p.Leu461Ser Single submitter ⚠
- p.Lys313Arg Single submitter ⚠
- p.Lys500Gln Single submitter ⚠
- p.Lys931Arg Single submitter ⚠
- p.Lys940Glu Single submitter ⚠
- p.Lys972Arg Single submitter ⚠
- p.Phe146Leu Single submitter ⚠
- p.Phe190Ile Single submitter ⚠
- p.Phe625Ser Single submitter ⚠
- p.Phe768Tyr Single submitter ⚠
- p.Phe797Leu Single submitter ⚠
- p.Phe811Leu Single submitter ⚠
- p.Pro393Ser Single submitter ⚠
- p.Pro821Ser Single submitter ⚠
- p.Pro983Leu Single submitter ⚠
- p.Ser229Tyr Single submitter ⚠
- p.Ser264Asn Single submitter ⚠
- p.Ser30Cys Single submitter ⚠
- p.Ser351Ile Single submitter ⚠
- p.Ser355Phe Single submitter ⚠
- p.Ser366Tyr Single submitter ⚠
- p.Ser394Leu Single submitter ⚠
- p.Ser431Arg Single submitter ⚠
- p.Ser570Cys Single submitter ⚠
- p.Ser584Pro Single submitter ⚠
- p.Ser738Arg Single submitter ⚠
- p.Ser749Phe Single submitter ⚠
- p.Ser765Thr Single submitter ⚠
- p.Ser799Leu Single submitter ⚠
- p.Thr114Ser Single submitter ⚠
- p.Thr131Met Single submitter ⚠
- p.Thr382Ala Single submitter ⚠
- p.Thr474Arg Single submitter ⚠
- p.Thr751Ala Single submitter ⚠
- p.Thr859Ile Single submitter ⚠
- p.Thr88Ser Single submitter ⚠
- p.Tyr55Asp Single submitter ⚠
- p.Tyr55His Single submitter ⚠
- p.Tyr669Cys Single submitter ⚠
- p.Tyr673Cys Single submitter ⚠
- p.Tyr851His Single submitter ⚠
- p.Val35Ile Single submitter ⚠
- p.Val769Phe Single submitter ⚠
- p.Val847Ile Single submitter ⚠
- p.Val865Leu Single submitter ⚠
- p.Val953Ile Single submitter ⚠