DDIT4 — 34 ClinVar variants
All ClinVar germline DDIT4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 32 flagged for review →
34 Uncertain significance
Full DDIT4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 32
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 25
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DDIT4 p.Arg108Gln Uncertain significance Single submitter
- DDIT4 p.Arg113Leu Uncertain significance Single submitter
- DDIT4 p.Arg180Cys Uncertain significance Single submitter
- DDIT4 p.Arg28Trp Uncertain significance Single submitter
- DDIT4 p.Asn95Ser Uncertain significance Single submitter
- DDIT4 p.Glu138Gly Uncertain significance Single submitter
- DDIT4 p.Glu82Gln Uncertain significance Single submitter
- DDIT4 p.Gly65Arg Uncertain significance Single submitter
- DDIT4 p.Gly75Arg Uncertain significance Single submitter
- DDIT4 p.His91Arg Uncertain significance Single submitter
- DDIT4 p.Leu4Phe Uncertain significance Single submitter
- DDIT4 p.Leu4Pro Uncertain significance Single submitter
- DDIT4 p.Leu57Val Uncertain significance Single submitter
- DDIT4 p.Leu73Pro Uncertain significance Single submitter
- DDIT4 p.Leu92Phe Uncertain significance Single submitter
- DDIT4 p.Pro17Leu Uncertain significance Single submitter
- DDIT4 p.Pro21Leu Uncertain significance Single submitter
- DDIT4 p.Pro26Ser Uncertain significance Single submitter
- DDIT4 p.Ser156Gly Uncertain significance Single submitter
- DDIT4 p.Ser159Arg Uncertain significance Single submitter
- DDIT4 p.Ser194Ile Uncertain significance Single submitter
- DDIT4 p.Ser3Gly Uncertain significance Single submitter
- DDIT4 p.Ser62Asn Uncertain significance Single submitter
- DDIT4 p.Thr25Ile Uncertain significance Single submitter
- DDIT4 p.Val149Ala Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- DDIT4 p.Asp148Asn Uncertain significance Single submitter
- DDIT4 p.Cys232Arg Uncertain significance Single submitter
- DDIT4 p.Glu88Lys Uncertain significance Single submitter
- DDIT4 p.Gly154Ser Uncertain significance Single submitter
- DDIT4 p.Met119Ile Uncertain significance Single submitter
- DDIT4 p.Ser48Ile Uncertain significance Single submitter
- DDIT4 p.Val178Leu Uncertain significance Single submitter
All DDIT4 variants
Uncertain significance 34
- p.Arg108Gln Single submitter ⚠
- p.Arg113Leu Single submitter ⚠
- p.Arg133Cys Single submitter
- p.Arg180Cys Single submitter ⚠
- p.Arg28Trp Single submitter ⚠
- p.Asn95Ser Single submitter ⚠
- p.Asp148Asn Single submitter ⚠
- p.Cys232Arg Single submitter ⚠
- p.Glu138Gly Single submitter ⚠
- p.Glu82Gln Single submitter ⚠
- p.Glu88Lys Single submitter ⚠
- p.Gly154Ser Single submitter ⚠
- p.Gly65Arg Single submitter ⚠
- p.Gly75Arg Single submitter ⚠
- p.His91Arg Single submitter ⚠
- p.Leu4Phe Single submitter ⚠
- p.Leu4Pro Single submitter ⚠
- p.Leu57Val Single submitter ⚠
- p.Leu73Pro Single submitter ⚠
- p.Leu92Phe Single submitter ⚠
- p.Met119Ile Single submitter ⚠
- p.Pro17Leu Single submitter ⚠
- p.Pro21Leu Single submitter ⚠
- p.Pro26Ser Single submitter ⚠
- p.Ser156Gly Single submitter ⚠
- p.Ser159Arg Single submitter ⚠
- p.Ser194Ile Single submitter ⚠
- p.Ser3Gly Single submitter ⚠
- p.Ser48Ile Single submitter ⚠
- p.Ser52Leu Single submitter
- p.Ser62Asn Single submitter ⚠
- p.Thr25Ile Single submitter ⚠
- p.Val149Ala Single submitter ⚠
- p.Val178Leu Single submitter ⚠