DDR1 — 118 ClinVar variants

All ClinVar germline DDR1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 103 flagged for review →

2 Benign · 16 Likely benign · 100 Uncertain significance

Full DDR1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 103

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 59

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 44

The independent predictors disagree with each other — read with care.

All DDR1 variants

Benign 2

c.2602-4G>A Single submitter
p.Ile738= Single submitter

Likely benign 16

p.Ala570= Single submitter
p.Ala748Thr Single submitter
p.Arg127His Single submitter
p.Arg488Trp Single submitter ⚠
p.Arg645His Single submitter ⚠
p.Arg886Gln Single submitter
p.Asn502= Single submitter
p.Asp720Asn Single submitter
p.Gly730Arg Single submitter
p.Pro374Leu Single submitter
p.Pro483= Single submitter
p.Pro494= Single submitter
p.Ser17Gly Single submitter
p.Thr219= Single submitter
p.Thr912Met Single submitter
p.Val369Met Single submitter ⚠

Uncertain significance 100

p.Ala196Ser Single submitter ⚠
p.Ala29Val Single submitter ⚠
p.Ala353Val Single submitter ⚠
p.Ala383Pro Single submitter ⚠
p.Ala383Val Single submitter ⚠
p.Ala521Thr Single submitter ⚠
p.Ala823Gly Single submitter ⚠
p.Ala828Ser Single submitter ⚠
p.Ala857Thr Single submitter ⚠
p.Ala906Ser Single submitter ⚠
p.Arg128Cys Single submitter ⚠
p.Arg135Cys Single submitter ⚠
p.Arg135His Single submitter ⚠
p.Arg172Trp Single submitter ⚠
p.Arg278Lys Single submitter ⚠
p.Arg296Cys Single submitter ⚠
p.Arg306Gln Single submitter ⚠
p.Arg332Trp Single submitter ⚠
p.Arg341Cys Single submitter ⚠
p.Arg344His Single submitter ⚠
p.Arg349Cys Single submitter ⚠
p.Arg349His Single submitter ⚠
p.Arg40Gln Single submitter ⚠
p.Arg444His Single submitter ⚠
p.Arg445Ser Single submitter ⚠
p.Arg452Trp Single submitter ⚠
p.Arg475His Single submitter ⚠
p.Arg63Ser Single submitter ⚠
p.Arg645Pro Single submitter ⚠
p.Arg658Gln Single submitter ⚠
p.Arg686Gln Single submitter ⚠
p.Arg755Cys Single submitter ⚠
p.Arg802Gln Single submitter ⚠
p.Arg866Pro Single submitter ⚠
p.Arg872Gln Single submitter ⚠
p.Arg872Trp Single submitter ⚠
p.Arg890Trp Single submitter ⚠
p.Arg895Gln Single submitter ⚠
p.Asn325Ile Single submitter ⚠
p.Asn911Ser Single submitter ⚠
p.Asp189Gly Single submitter ⚠
p.Asp546Glu Single submitter ⚠
p.Asp660Asn Single submitter ⚠
p.Cys814Arg Single submitter ⚠
p.Cys887Trp Single submitter ⚠
p.Gln38Arg Single submitter ⚠
p.Gln749His Single submitter ⚠
p.Glu705Val Single submitter ⚠
p.Glu855Lys Single submitter ⚠
p.Gly108Arg Single submitter ⚠
p.Gly190Glu Single submitter ⚠
p.Gly222Arg Single submitter ⚠
p.Gly226Glu Single submitter ⚠
p.Gly299Asp Single submitter ⚠
p.Gly300Glu Single submitter ⚠
p.Gly323Arg Single submitter ⚠
p.Gly597Arg Single submitter ⚠
p.Gly617Ser Single submitter ⚠
p.Gly707Ser Single submitter ⚠
p.Gly71Ala Single submitter ⚠
p.Gly830Ser Single submitter ⚠
p.His61Arg Single submitter ⚠
p.His95Tyr Single submitter ⚠
p.Ile685Thr Single submitter ⚠
p.Leu186Phe Single submitter ⚠
p.Leu247Pro Single submitter ⚠
p.Met202Ile Single submitter ⚠
p.Met548Val Single submitter ⚠
p.Met754Thr Single submitter ⚠
p.Phe272Val Single submitter ⚠
p.Phe712Leu Single submitter ⚠
p.Pro157Leu Single submitter ⚠
p.Pro381Leu Single submitter ⚠
p.Pro407Leu Single submitter ⚠
p.Pro476Leu Single submitter ⚠
p.Pro476Ser Single submitter ⚠
p.Pro482Ser Single submitter ⚠
p.Pro483Leu Single submitter ⚠
p.Pro524Leu Single submitter ⚠
p.Pro527Leu Single submitter ⚠
p.Pro537Arg Single submitter ⚠
p.Pro556Leu Single submitter ⚠
p.Pro589Ser Single submitter ⚠
p.Pro592Ser Single submitter ⚠
p.Pro606Leu Single submitter ⚠
p.Pro877Arg Single submitter ⚠
p.Ser264Phe Single submitter ⚠
p.Ser363Pro Single submitter ⚠
p.Ser66Gly Single submitter ⚠
p.Thr214Ala Single submitter ⚠
p.Thr531Ile Single submitter ⚠
p.Thr538Ile Single submitter ⚠
p.Thr849Ala Single submitter ⚠
p.Tyr203Cys Single submitter ⚠
p.Tyr586Cys Single submitter ⚠
p.Tyr881Cys Single submitter ⚠
p.Val198Leu Single submitter ⚠
p.Val336Met Single submitter ⚠
p.Val566Ile Single submitter ⚠
p.Val836Met Single submitter ⚠