DDX10 — 139 ClinVar variants
All ClinVar germline DDX10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 114 flagged for review →
5 Benign · 1 Benign/Likely benign · 11 Likely benign · 122 Uncertain significance
Full DDX10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 114
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 97
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DDX10 p.Ala468Ser Uncertain significance Single submitter
-
DDX10 p.Ala537Thr
Uncertain significance
Single submitter
neurodevelopmental disorder
- DDX10 p.Ala599Gly Uncertain significance Single submitter
- DDX10 p.Arg133Cys Uncertain significance Single submitter
- DDX10 p.Arg133His Uncertain significance Single submitter
- DDX10 p.Arg13Pro Uncertain significance Single submitter
- DDX10 p.Arg247Cys Uncertain significance Single submitter
- DDX10 p.Arg337His Uncertain significance Single submitter
- DDX10 p.Arg549Gly Uncertain significance Single submitter
- DDX10 p.Arg640Gln Uncertain significance Single submitter
- DDX10 p.Arg872Thr Uncertain significance Single submitter
- DDX10 p.Asn21His Uncertain significance Single submitter
- DDX10 p.Asn21Ser Uncertain significance Single submitter
- DDX10 p.Asn32Ile Uncertain significance Single submitter
- DDX10 p.Asn575Asp Uncertain significance Single submitter
- DDX10 p.Asn642Asp Uncertain significance Single submitter
- DDX10 p.Asn6Thr Uncertain significance Single submitter
- DDX10 p.Asn6Tyr Uncertain significance Single submitter
- DDX10 p.Asn763Thr Uncertain significance Single submitter
- DDX10 p.Asp395Glu Uncertain significance Single submitter
- DDX10 p.Asp463Asn Uncertain significance Single submitter
- DDX10 p.Asp484Val Uncertain significance Single submitter
- DDX10 p.Asp634Asn Uncertain significance Single submitter
- DDX10 p.Asp716Gly Uncertain significance Single submitter
- DDX10 p.Asp778Tyr Uncertain significance Single submitter
- DDX10 p.Asp782Val Uncertain significance Single submitter
- DDX10 p.Asp835Asn Uncertain significance Single submitter
- DDX10 p.Gln614His Uncertain significance Single submitter
- DDX10 p.Glu567Lys Uncertain significance Single submitter
- DDX10 p.Glu673Asp Uncertain significance Single submitter
- DDX10 p.Glu731Asp Uncertain significance Single submitter
- DDX10 p.Glu757Asp Uncertain significance Single submitter
- DDX10 p.Glu773Gly Uncertain significance Single submitter
- DDX10 p.Gly11Val Uncertain significance Single submitter
- DDX10 p.Gly231Arg Uncertain significance Single submitter
- DDX10 p.Gly347Ser Uncertain significance Single submitter
- DDX10 p.Gly563Arg Uncertain significance Single submitter
- DDX10 p.Gly578Ala Uncertain significance Single submitter
- DDX10 p.Gly645Arg Uncertain significance Single submitter
- DDX10 p.Gly789Glu Uncertain significance Single submitter
- DDX10 p.His401Gln Uncertain significance Single submitter
- DDX10 p.His723Asn Uncertain significance Single submitter
- DDX10 p.Ile188Phe Uncertain significance Single submitter
- DDX10 p.Ile374Thr Uncertain significance Single submitter
- DDX10 p.Ile374Val Uncertain significance Single submitter
- DDX10 p.Ile448Thr Uncertain significance Single submitter
- DDX10 p.Ile708Val Uncertain significance Single submitter
- DDX10 p.Ile720Phe Uncertain significance Single submitter
- DDX10 p.Leu134Arg Uncertain significance Single submitter
- DDX10 p.Leu153Gln Uncertain significance Single submitter
- DDX10 p.Leu201Arg Uncertain significance Single submitter
- DDX10 p.Leu329Arg Uncertain significance Single submitter
- DDX10 p.Leu37Phe Uncertain significance Single submitter
- DDX10 p.Leu753Val Uncertain significance Single submitter
- DDX10 p.Leu851Ser Uncertain significance Single submitter
- DDX10 p.Lys246Glu Uncertain significance Single submitter
- DDX10 p.Lys43Arg Uncertain significance Single submitter
- DDX10 p.Lys515Asn Uncertain significance Single submitter
- DDX10 p.Lys522Asn Uncertain significance Single submitter
- DDX10 p.Lys595Arg Uncertain significance Single submitter
- DDX10 p.Lys705Thr Uncertain significance Single submitter
- DDX10 p.Lys743Arg Uncertain significance Single submitter
- DDX10 p.Lys764Asn Uncertain significance Single submitter
- DDX10 p.Lys768Arg Uncertain significance Single submitter
- DDX10 p.Lys845Glu Uncertain significance Single submitter
- DDX10 p.Lys845Thr Uncertain significance Single submitter
- DDX10 p.Phe232Cys Uncertain significance Single submitter
- DDX10 p.Pro149Arg Uncertain significance Single submitter
- DDX10 p.Pro14Ala Uncertain significance Single submitter
- DDX10 p.Pro14Ser Uncertain significance Single submitter
- DDX10 p.Pro44Ser Uncertain significance Single submitter
- DDX10 p.Pro538Leu Uncertain significance Single submitter
- DDX10 p.Pro538Thr Uncertain significance Single submitter
- DDX10 p.Pro608Leu Uncertain significance Single submitter
- DDX10 p.Pro659Thr Uncertain significance Single submitter
- DDX10 p.Pro853Thr Uncertain significance Single submitter
- DDX10 p.Ser316Asn Uncertain significance Single submitter
- DDX10 p.Ser539Cys Uncertain significance Single submitter
- DDX10 p.Ser606Tyr Uncertain significance Single submitter
- DDX10 p.Ser611Cys Uncertain significance Single submitter
- DDX10 p.Ser660Pro Uncertain significance Single submitter
- DDX10 p.Ser803Arg Uncertain significance Single submitter
- DDX10 p.Ser817Arg Uncertain significance Single submitter
- DDX10 p.Thr150Met Uncertain significance Single submitter
- DDX10 p.Thr214Ala Uncertain significance Single submitter
- DDX10 p.Thr372Ala Uncertain significance Single submitter
- DDX10 p.Thr621Ile Uncertain significance Single submitter
- DDX10 p.Thr99Ile Uncertain significance Single submitter
- DDX10 p.Tyr551His Uncertain significance Single submitter
- DDX10 p.Tyr551Phe Uncertain significance Single submitter
- DDX10 p.Val160Phe Uncertain significance Single submitter
- DDX10 p.Val294Ile Uncertain significance Single submitter
- DDX10 p.Val332Leu Uncertain significance Single submitter
- DDX10 p.Val473Ile Uncertain significance Single submitter
- DDX10 p.Val643Met Uncertain significance Single submitter
- DDX10 p.Val65Ile Uncertain significance Single submitter
- DDX10 p.Val836Met Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- DDX10 p.Ala154Thr Uncertain significance Single submitter
- DDX10 p.Arg640Trp Uncertain significance Single submitter
- DDX10 p.Arg70Ser Uncertain significance Single submitter
- DDX10 p.Arg756Gly Uncertain significance Single submitter
- DDX10 p.Asn443Tyr Uncertain significance Single submitter
- DDX10 p.Asp783Val Uncertain significance Single submitter
- DDX10 p.Glu129Asp Uncertain significance Single submitter
- DDX10 p.Glu51Lys Uncertain significance Single submitter
- DDX10 p.Gly857Ser Uncertain significance Single submitter
- DDX10 p.Leu447Arg Uncertain significance Single submitter
- DDX10 p.Leu729Phe Uncertain significance Single submitter
- DDX10 p.Leu858Val Uncertain significance Single submitter
- DDX10 p.Lys737Thr Uncertain significance Single submitter
- DDX10 p.Lys747Asn Uncertain significance Single submitter
- DDX10 p.Phe390Leu Uncertain significance Single submitter
- DDX10 p.Ser478Cys Uncertain significance Single submitter
- DDX10 p.Thr398Ile Uncertain significance Single submitter
All DDX10 variants
Benign 5
- p.Glu445Gly Multiple submitters
- p.Thr521= Single submitter
- c.378+7A>G No assertion criteria DDX10-related disorder
- p.Leu566= No assertion criteria DDX10-related disorder
- p.Pro838= No assertion criteria DDX10-related disorder
Benign/Likely benign 1
- p.Tyr282= Multiple submitters
Likely benign 11
- p.Pro44Arg Multiple submitters
- p.Arg847Lys Single submitter
- p.Leu500= Single submitter
- p.Thr139Ala Single submitter
- p.Val510Ile Single submitter
- c.1139-4G>A No assertion criteria DDX10-related disorder
- p.Asp587= No assertion criteria DDX10-related disorder
- p.Asp835= No assertion criteria DDX10-related disorder
- p.Gln655Arg No assertion criteria DDX10-related disorder
- p.Glu586del No assertion criteria DDX10-related disorder
- p.Thr80= No assertion criteria DDX10-related disorder
Uncertain significance 122
- p.Ala154Thr Single submitter ⚠
- p.Ala367Val Single submitter
- p.Ala468Ser Single submitter ⚠
- p.Ala537Thr Single submitter neurodevelopmental disorder ⚠
- p.Ala599Gly Single submitter ⚠
- p.Arg133Cys Single submitter ⚠
- p.Arg133His Single submitter ⚠
- p.Arg13Pro Single submitter ⚠
- p.Arg247Cys Single submitter ⚠
- p.Arg331Gly Single submitter
- p.Arg337Cys Single submitter
- p.Arg337His Single submitter ⚠
- p.Arg509His Single submitter
- p.Arg549Gly Single submitter ⚠
- p.Arg640Gln Single submitter ⚠
- p.Arg640Trp Single submitter ⚠
- p.Arg70Ser Single submitter ⚠
- p.Arg756Gly Single submitter ⚠
- p.Arg872Thr Single submitter ⚠
- p.Asn21His Single submitter ⚠
- p.Asn21Ser Single submitter ⚠
- p.Asn32Ile Single submitter ⚠
- p.Asn443Tyr Single submitter ⚠
- p.Asn575Asp Single submitter ⚠
- p.Asn642Asp Single submitter ⚠
- p.Asn6Thr Single submitter ⚠
- p.Asn6Tyr Single submitter ⚠
- p.Asn763Thr Single submitter ⚠
- p.Asp395Glu Single submitter ⚠
- p.Asp463Asn Single submitter ⚠
- p.Asp484Val Single submitter ⚠
- p.Asp634Asn Single submitter ⚠
- p.Asp716Gly Single submitter ⚠
- p.Asp778Tyr Single submitter ⚠
- p.Asp782Val Single submitter ⚠
- p.Asp783Val Single submitter ⚠
- p.Asp835Asn Single submitter ⚠
- p.Gln327Arg Single submitter
- p.Gln614His Single submitter ⚠
- p.Glu129Asp Single submitter ⚠
- p.Glu51Lys Single submitter ⚠
- p.Glu567Lys Single submitter ⚠
- p.Glu673Asp Single submitter ⚠
- p.Glu731Asp Single submitter ⚠
- p.Glu757Asp Single submitter ⚠
- p.Glu773Gly Single submitter ⚠
- p.Gly11Val Single submitter ⚠
- p.Gly231Arg Single submitter ⚠
- p.Gly347Ser Single submitter ⚠
- p.Gly563Arg Single submitter ⚠
- p.Gly578Ala Single submitter ⚠
- p.Gly645Arg Single submitter ⚠
- p.Gly789Glu Single submitter ⚠
- p.Gly857Ser Single submitter ⚠
- p.His401Gln Single submitter ⚠
- p.His723Asn Single submitter ⚠
- p.Ile188Phe Single submitter ⚠
- p.Ile374Thr Single submitter ⚠
- p.Ile374Val Single submitter ⚠
- p.Ile448Thr Single submitter ⚠
- p.Ile708Val Single submitter ⚠
- p.Ile720Phe Single submitter ⚠
- p.Leu134Arg Single submitter ⚠
- p.Leu153Gln Single submitter ⚠
- p.Leu201Arg Single submitter ⚠
- p.Leu329Arg Single submitter ⚠
- p.Leu37Phe Single submitter ⚠
- p.Leu447Arg Single submitter ⚠
- p.Leu729Phe Single submitter ⚠
- p.Leu753Val Single submitter ⚠
- p.Leu851Ser Single submitter ⚠
- p.Leu858Val Single submitter ⚠
- p.Lys246Glu Single submitter ⚠
- p.Lys43Arg Single submitter ⚠
- p.Lys515Asn Single submitter ⚠
- p.Lys522Asn Single submitter ⚠
- p.Lys595Arg Single submitter ⚠
- p.Lys705Thr Single submitter ⚠
- p.Lys737Thr Single submitter ⚠
- p.Lys743Arg Single submitter ⚠
- p.Lys747Asn Single submitter ⚠
- p.Lys764Asn Single submitter ⚠
- p.Lys768Arg Single submitter ⚠
- p.Lys845Glu Single submitter ⚠
- p.Lys845Thr Single submitter ⚠
- p.Phe232Cys Single submitter ⚠
- p.Phe390Leu Single submitter ⚠
- p.Pro149Arg Single submitter ⚠
- p.Pro14Ala Single submitter ⚠
- p.Pro14Ser Single submitter ⚠
- p.Pro44Ser Single submitter ⚠
- p.Pro538Leu Single submitter ⚠
- p.Pro538Thr Single submitter ⚠
- p.Pro608Leu Single submitter ⚠
- p.Pro659Thr Single submitter ⚠
- p.Pro853Thr Single submitter ⚠
- p.Ser267Gly Single submitter
- p.Ser316Asn Single submitter ⚠
- p.Ser478Cys Single submitter ⚠
- p.Ser539Cys Single submitter ⚠
- p.Ser606Tyr Single submitter ⚠
- p.Ser611Cys Single submitter ⚠
- p.Ser660Pro Single submitter ⚠
- p.Ser803Arg Single submitter ⚠
- p.Ser817Arg Single submitter ⚠
- p.Thr150Met Single submitter ⚠
- p.Thr214Ala Single submitter ⚠
- p.Thr372Ala Single submitter ⚠
- p.Thr398Ile Single submitter ⚠
- p.Thr621Ile Single submitter ⚠
- p.Thr99Ile Single submitter ⚠
- p.Tyr475Cys Single submitter
- p.Tyr551His Single submitter ⚠
- p.Tyr551Phe Single submitter ⚠
- p.Val127Met Single submitter
- p.Val160Phe Single submitter ⚠
- p.Val294Ile Single submitter ⚠
- p.Val332Leu Single submitter ⚠
- p.Val473Ile Single submitter ⚠
- p.Val643Met Single submitter ⚠
- p.Val65Ile Single submitter ⚠
- p.Val836Met Single submitter ⚠