DDX18 — 88 ClinVar variants
All ClinVar germline DDX18 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 71 flagged for review →
7 Benign · 6 Likely benign · 75 Uncertain significance
Full DDX18 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 71
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 54
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DDX18 p.Ala121Val Uncertain significance Single submitter
- DDX18 p.Ala180Gly Uncertain significance Single submitter
- DDX18 p.Ala237Thr Uncertain significance Single submitter
- DDX18 p.Ala30Ser Uncertain significance Single submitter
- DDX18 p.Ala610Ser Uncertain significance Single submitter
- DDX18 p.Ala99Thr Uncertain significance Single submitter
- DDX18 p.Arg10His Uncertain significance Single submitter
- DDX18 p.Arg357His Uncertain significance Single submitter
- DDX18 p.Arg512Cys Uncertain significance Single submitter
- DDX18 p.Arg531His Uncertain significance Single submitter
- DDX18 p.Arg539Cys Uncertain significance Single submitter
- DDX18 p.Asn156Tyr Uncertain significance Single submitter
- DDX18 p.Asn187Ser Uncertain significance Single submitter
- DDX18 p.Asn201Asp Uncertain significance Single submitter
- DDX18 p.Asn473Ser Uncertain significance Single submitter
- DDX18 p.Asn95Ser Uncertain significance Single submitter
- DDX18 p.Gln28Arg Uncertain significance Single submitter
- DDX18 p.Gln402Glu Uncertain significance Single submitter
- DDX18 p.Glu131Ala Uncertain significance Single submitter
- DDX18 p.Glu131Gln Uncertain significance Single submitter
- DDX18 p.Glu131Lys Uncertain significance Single submitter
- DDX18 p.Glu146Lys Uncertain significance Single submitter
- DDX18 p.Gly49Glu Uncertain significance Single submitter
- DDX18 p.Gly639Ser Uncertain significance Single submitter
- DDX18 p.Ile205Val Uncertain significance Single submitter
- DDX18 p.Ile455Met Uncertain significance Single submitter
- DDX18 p.Leu374Pro Uncertain significance Single submitter
- DDX18 p.Leu568Trp Uncertain significance Single submitter
- DDX18 p.Lys19Arg Uncertain significance Single submitter
- DDX18 p.Met100Val Uncertain significance Single submitter
- DDX18 p.Met265Val Uncertain significance Single submitter
- DDX18 p.Met316Thr Uncertain significance Single submitter
- DDX18 p.Phe179Cys Uncertain significance Single submitter
- DDX18 p.Phe599Leu Uncertain significance Single submitter
- DDX18 p.Pro154Ser Uncertain significance Single submitter
- DDX18 p.Pro5Leu Uncertain significance Single submitter
- DDX18 p.Ser107Pro Uncertain significance Single submitter
- DDX18 p.Ser140Arg Uncertain significance Single submitter
- DDX18 p.Ser165Gly Uncertain significance Single submitter
- DDX18 p.Ser50Thr Uncertain significance Single submitter
- DDX18 p.Ser559Ala Uncertain significance Single submitter
- DDX18 p.Ser594Phe Uncertain significance Single submitter
- DDX18 p.Thr147Ile Uncertain significance Single submitter
- DDX18 p.Thr200Ala Uncertain significance Single submitter
- DDX18 p.Thr260Ala Uncertain significance Single submitter
- DDX18 p.Thr260Ile Uncertain significance Single submitter
- DDX18 p.Thr38Ile Uncertain significance Single submitter
- DDX18 p.Thr467Pro Uncertain significance Single submitter
- DDX18 p.Thr646Ser Uncertain significance Single submitter
- DDX18 p.Thr68Ile Uncertain significance Single submitter
- DDX18 p.Val163Met Uncertain significance Single submitter
- DDX18 p.Val186Leu Uncertain significance Single submitter
- DDX18 p.Val388Ile Uncertain significance Single submitter
- DDX18 p.Val625Ile Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- DDX18 p.Arg291Ser Uncertain significance Single submitter
- DDX18 p.Asn462Asp Uncertain significance Single submitter
- DDX18 p.Gln667His Uncertain significance Single submitter
- DDX18 p.Glu566Ala Uncertain significance Single submitter
- DDX18 p.Gly269Ala Uncertain significance Single submitter
- DDX18 p.Gly639Arg Uncertain significance Single submitter
- DDX18 p.Leu611Val Uncertain significance Single submitter
- DDX18 p.Lys208Glu Uncertain significance Single submitter
- DDX18 p.Lys571Asn Uncertain significance Single submitter
- DDX18 p.Met197Ile Uncertain significance Single submitter
- DDX18 p.Met247Val Uncertain significance Single submitter
- DDX18 p.Met323Ile Uncertain significance Single submitter
- DDX18 p.Met361Val Uncertain significance Single submitter
- DDX18 p.Phe551Leu Uncertain significance Single submitter
- DDX18 p.Ser578Thr Uncertain significance Single submitter
- DDX18 p.Thr252Pro Uncertain significance Single submitter
- DDX18 p.Val621Leu Uncertain significance Single submitter
All DDX18 variants
Benign 7
- p.Ala517= Multiple submitters
- p.Cys183Tyr Multiple submitters
- p.Glu142Lys Multiple submitters
- p.Val371Ile Multiple submitters
- c.751+10C>G Single submitter
- p.Phe620= Single submitter
- p.Ser434= Single submitter
Likely benign 6
- p.Asn156Asp Single submitter
- p.His278= Single submitter
- p.Met100Thr Single submitter
- p.Ser50Gly Single submitter
- p.Thr125Ala Single submitter
- p.Val405= Single submitter
Uncertain significance 75
- p.Ala121Val Single submitter ⚠
- p.Ala180Gly Single submitter ⚠
- p.Ala237Thr Single submitter ⚠
- p.Ala30Ser Single submitter ⚠
- p.Ala610Ser Single submitter ⚠
- p.Ala99Thr Single submitter ⚠
- p.Arg10His Single submitter ⚠
- p.Arg291Ser Single submitter ⚠
- p.Arg357His Single submitter ⚠
- p.Arg512Cys Single submitter ⚠
- p.Arg531His Single submitter ⚠
- p.Arg539Cys Single submitter ⚠
- p.Arg539His Single submitter
- p.Asn156Tyr Single submitter ⚠
- p.Asn187Ser Single submitter ⚠
- p.Asn201Asp Single submitter ⚠
- p.Asn462Asp Single submitter ⚠
- p.Asn473Ser Single submitter ⚠
- p.Asn95Ser Single submitter ⚠
- p.Gln28Arg Single submitter ⚠
- p.Gln402Glu Single submitter ⚠
- p.Gln667His Single submitter ⚠
- p.Glu131Ala Single submitter ⚠
- p.Glu131Gln Single submitter ⚠
- p.Glu131Lys Single submitter ⚠
- p.Glu146Lys Single submitter ⚠
- p.Glu410Gln Single submitter
- p.Glu566Ala Single submitter ⚠
- p.Gly198Asp Single submitter
- p.Gly269Ala Single submitter ⚠
- p.Gly49Glu Single submitter ⚠
- p.Gly639Arg Single submitter ⚠
- p.Gly639Ser Single submitter ⚠
- p.Ile205Val Single submitter ⚠
- p.Ile455Met Single submitter ⚠
- p.Leu374Pro Single submitter ⚠
- p.Leu568Trp Single submitter ⚠
- p.Leu611Val Single submitter ⚠
- p.Lys19Arg Single submitter ⚠
- p.Lys208Glu Single submitter ⚠
- p.Lys439Gln Single submitter
- p.Lys571Asn Single submitter ⚠
- p.Met100Val Single submitter ⚠
- p.Met197Ile Single submitter ⚠
- p.Met247Val Single submitter ⚠
- p.Met265Val Single submitter ⚠
- p.Met316Thr Single submitter ⚠
- p.Met323Ile Single submitter ⚠
- p.Met361Val Single submitter ⚠
- p.Phe179Cys Single submitter ⚠
- p.Phe551Leu Single submitter ⚠
- p.Phe599Leu Single submitter ⚠
- p.Pro154Ser Single submitter ⚠
- p.Pro5Leu Single submitter ⚠
- p.Ser107Pro Single submitter ⚠
- p.Ser140Arg Single submitter ⚠
- p.Ser165Gly Single submitter ⚠
- p.Ser50Thr Single submitter ⚠
- p.Ser559Ala Single submitter ⚠
- p.Ser578Thr Single submitter ⚠
- p.Ser594Phe Single submitter ⚠
- p.Thr147Ile Single submitter ⚠
- p.Thr200Ala Single submitter ⚠
- p.Thr252Pro Single submitter ⚠
- p.Thr260Ala Single submitter ⚠
- p.Thr260Ile Single submitter ⚠
- p.Thr38Ile Single submitter ⚠
- p.Thr467Pro Single submitter ⚠
- p.Thr646Ser Single submitter ⚠
- p.Thr68Ile Single submitter ⚠
- p.Val163Met Single submitter ⚠
- p.Val186Leu Single submitter ⚠
- p.Val388Ile Single submitter ⚠
- p.Val621Leu Single submitter ⚠
- p.Val625Ile Single submitter ⚠