DDX19B — 40 ClinVar variants
All ClinVar germline DDX19B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 39 flagged for review →
1 Likely benign · 39 Uncertain significance
Full DDX19B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 39
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 25
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DDX19B p.Arg259His Uncertain significance Single submitter
- DDX19B p.Arg317Lys Uncertain significance Single submitter
- DDX19B p.Arg380Gln Uncertain significance Single submitter
- DDX19B p.Asn44His Uncertain significance Single submitter
- DDX19B p.Cys165Phe Uncertain significance Single submitter
- DDX19B p.Gln119Lys Uncertain significance Single submitter
- DDX19B p.Gln155Arg Uncertain significance Single submitter
- DDX19B p.Gln401Glu Uncertain significance Single submitter
- DDX19B p.Glu173Lys Uncertain significance Single submitter
- DDX19B p.Glu300Val Uncertain significance Single submitter
- DDX19B p.Glu384Gly Uncertain significance Single submitter
- DDX19B p.Gly186Asp Uncertain significance Single submitter
- DDX19B p.Gly329Arg Uncertain significance Single submitter
- DDX19B p.Ile406Val Uncertain significance Single submitter
- DDX19B p.Ile474Val Uncertain significance Single submitter
- DDX19B p.Leu194Val Uncertain significance Single submitter
- DDX19B p.Leu362Val Uncertain significance Single submitter
- DDX19B p.Lys47Asn Uncertain significance Single submitter
- DDX19B p.Met152Thr Uncertain significance Single submitter
- DDX19B p.Pro233Thr Uncertain significance Single submitter
- DDX19B p.Ser448Gly Uncertain significance Single submitter
- DDX19B p.Val399Ala Uncertain significance Single submitter
- DDX19B p.Val39Gly Uncertain significance Single submitter
- DDX19B p.Val405Ile Uncertain significance Single submitter
- DDX19B p.Val412Met Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- DDX19B p.Ala195Val Uncertain significance Single submitter
- DDX19B p.Arg114Cys Uncertain significance Single submitter
- DDX19B p.Arg343Cys Uncertain significance Single submitter
- DDX19B p.Asn417Ser Uncertain significance Single submitter
- DDX19B p.Asn453Lys Uncertain significance Single submitter
- DDX19B p.Asp472Glu Uncertain significance Single submitter
- DDX19B p.Glu204Lys Uncertain significance Single submitter
- DDX19B p.Glu211Asp Uncertain significance Single submitter
- DDX19B p.Glu400Lys Uncertain significance Single submitter
- DDX19B p.Glu473Asp Uncertain significance Single submitter
- DDX19B p.Leu271Val Uncertain significance Single submitter
- DDX19B p.Lys26Met Uncertain significance Single submitter
- DDX19B p.Lys383Arg Uncertain significance Single submitter
- DDX19B p.Ser364Asn Uncertain significance Single submitter
All DDX19B variants
Likely benign 1
- p.Pro130= Single submitter
Uncertain significance 39
- p.Ala195Val Single submitter ⚠
- p.Arg114Cys Single submitter ⚠
- p.Arg259His Single submitter ⚠
- p.Arg317Lys Single submitter ⚠
- p.Arg343Cys Single submitter ⚠
- p.Arg380Gln Single submitter ⚠
- p.Asn417Ser Single submitter ⚠
- p.Asn44His Single submitter ⚠
- p.Asn453Lys Single submitter ⚠
- p.Asp472Glu Single submitter ⚠
- p.Cys165Phe Single submitter ⚠
- p.Gln119Lys Single submitter ⚠
- p.Gln155Arg Single submitter ⚠
- p.Gln401Glu Single submitter ⚠
- p.Glu173Lys Single submitter ⚠
- p.Glu204Lys Single submitter ⚠
- p.Glu211Asp Single submitter ⚠
- p.Glu300Val Single submitter ⚠
- p.Glu384Gly Single submitter ⚠
- p.Glu400Lys Single submitter ⚠
- p.Glu473Asp Single submitter ⚠
- p.Gly186Asp Single submitter ⚠
- p.Gly329Arg Single submitter ⚠
- p.Ile406Val Single submitter ⚠
- p.Ile474Val Single submitter ⚠
- p.Leu194Val Single submitter ⚠
- p.Leu271Val Single submitter ⚠
- p.Leu362Val Single submitter ⚠
- p.Lys26Met Single submitter ⚠
- p.Lys383Arg Single submitter ⚠
- p.Lys47Asn Single submitter ⚠
- p.Met152Thr Single submitter ⚠
- p.Pro233Thr Single submitter ⚠
- p.Ser364Asn Single submitter ⚠
- p.Ser448Gly Single submitter ⚠
- p.Val399Ala Single submitter ⚠
- p.Val39Gly Single submitter ⚠
- p.Val405Ile Single submitter ⚠
- p.Val412Met Single submitter ⚠